Resolved Multi-element Stellar Chemical Abundances in the Brightest Quiescent Galaxy at z ∼ 2

Measuring the chemical composition of galaxies is crucial to our understanding of galaxy formation and evolution models. However, such measurements are extremely challenging for quiescent galaxies at high redshifts, which have faint stellar continua and compact sizes, making it difficult to detect absorption lines and nearly impossible to spatially resolve them. Gravitational lensing offers the opportunity to study these galaxies with detailed spectroscopy that can be spatially resolved. In this work, we analyze deep spectra of MRG-M0138, a lensed quiescent galaxy at z = 1.98, which is the brightest of its kind, with an H-band magnitude of 17.1. Taking advantage of full spectral fitting, we measure [Mg/Fe] = 0.51 ± 0.05, [Fe/H] = 0.26 ± 0.04, and, for the first time, the stellar abundances of six other elements in this galaxy. We further constrained, also for the first time in a z ~ 2 galaxy, radial gradients in stellar age, [Fe/H], and [Mg/Fe]. We detect no gradient in age or [Mg/Fe] and a slightly negative gradient in [Fe/H], which has a slope comparable to that seen in local early-type galaxies. Our measurements show that not only is MRG-M0138 very Mg-enhanced compared to the centers of local massive early-type galaxies, it is also very iron rich. These dissimilar abundances suggest that even the inner regions of massive galaxies have experienced significant mixing of stars in mergers, in contrast to a purely inside-out growth model. The abundance pattern observed in MRG-M0138 challenges simple galactic chemical evolution models that vary only the star formation timescale and shows the need for more elaborate models

MOSFIRE Spectroscopy of Quiescent Galaxies at 1.5 < z < 2.5. II - Star Formation Histories and Galaxy Quenching

We investigate the stellar populations for a sample of 24 quiescent galaxies at 1.5 < z < 2.5 using deep rest-frame optical spectra obtained with Keck MOSFIRE. By fitting templates simultaneously to the spectroscopic and photometric data, and exploring a variety of star formation histories, we obtain robust measurements of median stellar ages and residual levels of star formation. After subtracting the stellar templates, the stacked spectrum reveals the Halpha and [NII] emission lines, providing an upper limit on the ongoing star formation rate of 0.9 +/- 0.1 Msun/yr. By combining the MOSFIRE data to our sample of Keck LRIS spectra at lower redshift, we analyze in a consistent manner the quiescent population at 1 < z < 2.5. We find a tight relation (with a scatter of 0.13 dex) between the stellar age and the rest-frame U-V and V-J colors, which can be used to estimate the age of quiescent galaxies given their colors. Applying this age--color relation to large, photometric samples, we are able to model the number density evolution for quiescent galaxies of various ages. We find evidence for two distinct quenching paths: a fast quenching that produces compact post-starburst systems, and a slow quenching of larger galaxies. Fast quenching accounts for about a fifth of the growth of the red sequence at z~1.4, and half at z~2.2. We conclude that fast quenching is triggered by dramatic events such as gas-rich mergers, while slow quenching is likely caused by a different physical mechanism

Stellar populations from spectroscopy of a large sample of quiescent galaxies at z > 1: Measuring the contribution of progenitor bias to early size growth

We analyze the stellar populations of a sample of 62 massive (log Mstar/Msun > 10.7) galaxies in the redshift range 1 < z < 1.6, with the main goal of investigating the role of recent quenching in the size growth of quiescent galaxies. We demonstrate that our sample is not biased toward bright, compact, or young galaxies, and thus is representative of the overall quiescent population. Our high signal-to-noise ratio Keck LRIS spectra probe the rest-frame Balmer break region which contains important absorption line diagnostics of recent star formation activity. We obtain improved measures of the various stellar population parameters, including the star-formation timescale tau, age and dust extinction, by fitting templates jointly to both our spectroscopic and broad-band photometric data. We identify which quiescent galaxies were recently quenched and backtrack their individual evolving trajectories on the UVJ color-color plane finding evidence for two distinct quenching routes. By using sizes measured in the previous paper of this series, we confirm that the largest galaxies are indeed among the youngest at a given redshift. This is consistent with some contribution to the apparent growth from recent arrivals, an effect often called progenitor bias. However, we calculate that recently-quenched objects can only be responsible for about half the increase in average size of quiescent galaxies over a 1.5 Gyr period, corresponding to the redshift interval 1.25 < z < 2. The remainder of the observed size evolution arises from a genuine growth of long-standing quiescent galaxies

Resolving Quiescent Galaxies at z≳2: II. Direct Measures of Rotational Support

Stellar kinematics provide insights into the masses and formation histories of galaxies. At high redshifts, spatially resolving the stellar kinematics of quiescent galaxies is challenging due to their compact sizes. Using deep near-infrared spectroscopy, we have measured the resolved stellar kinematics of four quiescent galaxies at z = 1.95–2.64, introduced in Paper I, that are gravitationally lensed by galaxy clusters. Analyses of two of these have previously been reported individually by Newman et al. and Toft et al., and for the latter, we present new observations. All four galaxies show significant rotation and can be classified as "fast rotators." In the three systems for which the lensing constraints permit a reconstruction of the source, we find that all are likely to be highly flattened (intrinsic ellipticities of ≈0.75–0.85) disk-dominated galaxies with rapid rotation speeds of V max = 290–352 km s−1 and predominantly rotational support, as indicated by the ratio (V/σ)Re = 1.7-2.3. Compared to coeval star-forming galaxies of similar mass, the quiescent galaxies have smaller V/σ. Given their high masses, Mdyn ≳ 2 x 10^11 Mⵙ, we argue that these galaxies are likely to evolve into "slow rotator" elliptical galaxies whose specific angular momentum is reduced by a factor of 5–10. This provides strong evidence for merger-driven evolution of massive galaxies after quenching. Consistent with indirect evidence from earlier morphological studies, our small but unique sample suggests that the kinematic transformations that produced round, dispersion-supported elliptical galaxies were not generally coincident with quenching. Such galaxies probably emerged later via mergers that increased their masses and sizes while also eroding their rotational support

Mining and analysis of audiology data to find significant factors associated with tinnitus masker

Objectives: The objective of this research is to find the factors associated with tinnitus masker from the literature, and by using the large amount of audiology data available from a large NHS (National Health Services, UK) hearing aid clinic. The factors evaluated were hearing impairment, age, gender, hearing aid type, mould and clinical comments. Design: The research includes literature survey for factors associated with tinnitus masker, and performs the analysis of audiology data using statistical and data mining techniques. Setting: This research uses a large audiology data but it also faced the problem of limited data for tinnitus. Participants: It uses 1,316 records for tinnitus and other diagnoses, and 10,437 records of clinical comments from a hearing aid clinic. Primary and secondary outcome measures: The research is looking for variables associated with tinnitus masker, and in future, these variables can be combined into a single model to develop a decision support system to predict about tinnitus masker for a patient. Results: The results demonstrated that tinnitus maskers are more likely to be fit to individuals with milder forms of hearing loss, and the factors age, gender, type of hearing aid and mould were all found significantly associated with tinnitus masker. In particular, those patients having Age<=55 years were more likely to wear a tinnitus masker, as well as those with milder forms of hearing loss. ITE (in the ear) hearing aids were also found associated with tinnitus masker. A feedback on the results of association of mould with tinnitus masker from a professional audiologist of a large NHS (National Health Services, UK) was also taken to better understand them. The results were obtained with different accuracy for different techniques. For example, the chi-squared test results were obtained with 95% accuracy, for Support and Confidence only those results were retained which had more than 1% Support and 80% Confidence. Conclusions: The variables audiograms, age, gender, hearing aid type and mould were found associated with the choice of tinnitus masker in the literature and by using statistical and data mining techniques. The further work in this research would lead to the development of a decision support system for tinnitus masker with an explanation that how that decision was obtained

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection.

Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal. The mechanisms of cell death regulating T-cell numbers at sites of infection are incompletely characterized. T-cell death in cultures of peripheral blood mononuclear cells (PBMC) showed 'classic' features of apoptosis following exposure to pneumococci. Conversely, purified CD3(+) T-cells cultured with pneumococci demonstrated necrosis with membrane permeabilization. The death of purified CD3(+) T-cells was not inhibited by necrostatin, but required the bacterial toxin pneumolysin. Apoptosis of CD3(+) T-cells in PBMC cultures required 'classical' CD14(+) monocytes, which enhanced T-cell activation. CD3(+) T-cell death was enhanced in HIV-seropositive individuals. Monocyte-mediated CD3(+) T-cell apoptotic death was Fas-dependent both in vitro and in vivo. In the early stages of the T-cell dependent host response to pneumococci reduced Fas ligand mediated T-cell apoptosis was associated with decreased bacterial clearance in the lung and increased bacteremia. In summary monocytes converted pathogen-associated necrosis into Fas-dependent apoptosis and regulated levels of activated T-cells at sites of acute bacterial infection. These changes were associated with enhanced bacterial clearance in the lung and reduced levels of invasive pneumococcal disease

On the Refractive Index of Ageing Dispersions of Laponite

Aqueous dispersion of Laponite at low ionic concentration is of interest since it undergoes structural evolution with respect to time, which is usually termed as ageing. In this work we study the refractive index behavior as a function of ageing time, concentration and temperature. We observed that the extended Lorenz-Lorentz equation fitted the refractive index dependence on concentration and temperature very well. The refractive index did not show any dependence on ageing time. However, the dependence of refractive index on concentration showed a marked change as the system underwent transition from an isotropic to a biphasic state. The slope of the refractive index-density data is remarkably close to that of water at all Laponite concentrations. In the context of transport phenomena, optical measurements such as interferometry can exploit the water-like behavior of Laponite dispersions.Comment: 13 pages, 3 figures, to appear in Applied Clay Scienc

Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with carcinogenesis

Common fragile sites (cfs) are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Several investigations support the view that common fragile sites play a role in carcinogenesis. We discuss a genome-wide approach based on graph theory and Gene Ontology vocabulary for the functional characterization of common fragile sites and for the identification of genes that contribute to tumour cell biology. CFS were assembled in a network based on a simple measure of correlation among common fragile site patterns of expression. By applying robust measurements to capture in quantitative terms the non triviality of the network, we identified several topological features clearly indicating departure from the Erdos-Renyi random graph model. The most important outcome was the presence of an unexpected large connected component far below the percolation threshold. Most of the best characterized common fragile sites belonged to this connected component. By filtering this connected component with Gene Ontology, statistically significant shared functional features were detected. Common fragile sites were found to be enriched for genes associated to the immune response and to mechanisms involved in tumour progression such as extracellular space remodeling and angiogenesis. Our results support the hypothesis that fragile sites serve a function; we propose that fragility is linked to a coordinated regulation of fragile genes expression.Comment: 18 pages, accepted for publication in BMC Bioinformatic

Gene expression in BMPR2 mutation carriers with and without evidence of Pulmonary Arterial Hypertension suggests pathways relevant to disease penetrance

<p>Abstract</p> <p>Background</p> <p>While BMPR2 mutation strongly predisposes to pulmonary arterial hypertension (PAH), only 20% of mutation carriers develop clinical disease. This finding suggests that modifier genes contribute to FPAH clinical expression. Since modifiers are likely to be common alleles, this problem is not tractable by traditional genetic approaches. Furthermore, examination of gene expression is complicated by confounding effects attributable to drugs and the disease process itself.</p> <p>Methods</p> <p>To resolve these problems, B-cells were isolated, EBV-immortalized, and cultured from familial PAH patients with BMPR2 mutations, mutation positive but disease-free family members, and family members without mutation. This allows examination of differences in gene expression without drug or disease-related effects. These differences were assayed by Affymetrix array, with follow-up by quantitative RT-PCR and additional statistical analyses.</p> <p>Results</p> <p>By gene array, we found consistent alterations in multiple pathways with known relationship to PAH, including actin organization, immune function, calcium balance, growth, and apoptosis. Selected genes were verified by quantitative RT-PCR using a larger sample set. One of these, CYP1B1, had tenfold lower expression than control groups in female but not male PAH patients. Analysis of overrepresented gene ontology groups suggests that risk of disease correlates with alterations in pathways more strongly than with any specific gene within those pathways.</p> <p>Conclusion</p> <p>Disease status in BMPR2 mutation carriers was correlated with alterations in proliferation, GTP signaling, and stress response pathway expression. The estrogen metabolizing gene CYP1B1 is a strong candidate as a modifier gene in female PAH patients.</p

Evaluating Active U: an Internet-mediated physical activity program.

Background: Engaging in regular physical activity can be challenging, particularly during the winter months. To promote physical activity at the University of Michigan during the winter months, an eight-week Internet-mediated program (Active U) was developed providing participants with an online physical activity log, goal setting, motivational emails, and optional team participation and competition. Methods: This study is a program evaluation of Active U. Approximately 47,000 faculty, staff, and graduate students were invited to participate in the online Active U intervention in the winter of 2007. Participants were assigned a physical activity goal and were asked to record each physical activity episode into the activity log for eight weeks. Statistics for program reach, effectiveness, adoption, and implementation were calculated using the Re-Aim framework. Multilevel regression analyses were used to assess the decline in rates of data entry and goal attainment during the program, to assess the likelihood of joining a team by demographic characteristics, to test the association between various predictors and the number of weeks an individual met his or her goal, and to analyze server load. Results: Overall, 7,483 individuals registered with the Active U website (≈16% of eligible), and 79% participated in the program by logging valid data at least once. Staff members, older participants, and those with a BMI < 25 were more likely to meet their weekly physical activity goals, and average rate of meeting goals was higher among participants who joined a competitive team compared to those who participated individually (IRR = 1.28, P < .001). Conclusion: Internet-mediated physical activity interventions that focus on physical activity logging and goal setting while incorporating team competition may help a significant percentage of the target population maintain their physical activity during the winter months