Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor-Deficient Mice

Objective—Atherosclerosis is a vascular disease that involves lesion formation at sites of disturbed flow under the influence of genetic and environmental factors. Endothelial expression of adhesion molecules that enable infiltration of immune cells is important for lesion development. Platelet/endothelial cell adhesion molecule-1 (PECAM-1; CD31) is an adhesion and signaling receptor expressed by many cells involved in atherosclerotic lesion development. PECAM-1 transduces signals required for proinflammatory adhesion molecule expression at atherosusceptible sites; thus, it is predicted to be proatherosclerotic. PECAM-1 also inhibits inflammatory responses, on which basis it is predicted to be atheroprotective. Methods and Results—We evaluated herein the effect of PECAM-1 deficiency on development of atherosclerosis in LDL receptor– deficient mice. We found that PECAM-1 has both proatherosclerotic and atheroprotective effects, but that the former dominate in the inner curvature of the aortic arch whereas the latter dominate in the aortic sinus, branching arteries, and descending aorta. Endothelial cell expression of PECAM-1 was sufficient for its atheroprotective effects in the aortic sinus but not in the descending aorta, where the atheroprotective effects of PECAM-1 also required its expression on bone marrow–derived cells. Conclusion—We conclude that PECAM-1 influences initiation and progression of atherosclerosis both positively and negatively, and that it does so in a site-specific manner. (Arterioscler Thromb Vasc Biol. 2008;28:1996-2002

Anti-Hispanic prejudice drives opposition to immigration in the U.S.

Last June, the U.S. Senate passed a comprehensive immigration bill that would give legal status to 11 million undocumented migrants, but this bill has remained stalled in the House of Representatives, reflecting the anti-immigration sentiments of many Americans. New research from Todd K. Hartman, Benjamin J. Newman, and C. Scott Bell investigates why so many are against immigration reform, and the role played by racial prejudice against Hispanics. Using surveys designed to detect anti-Hispanic prejudice, they find that white Americans react very differently to law-violating behaviors whether they are committed by Hispanic immigrants or not, suggesting a significant and persistent bias against them

An Overview of MOOS-IvP and a Users Guide to the IvP Helm Autonomy Software

This document describes the IvP Helm -- an Open Source behavior-based autonomy application for unmanned vehicles. IvP is short for interval programming -- a technique for representing and solving multi-objective optimizations problems. Behaviors in the IvP Helm are reconciled using multi-objective optimization when in competition with each other for influence of the vehicle. The IvP Helm is written as a MOOS application where MOOS is a set of Open Source publish-subscribe autonomy middleware tools. This document describes the configuration and use of the IvP Helm, provides examples of simple missions and information on how to download and build the software from the MOOS-IvP server at www.moosivp.org

Extending a MOOS-IvP Autonomy System and Users Guide to the IvPBuild Toolbox

This document describes how to extend the suite of MOOS applications and IvP Helm behaviors distributed with the MOOS-IvP software bundle from www.moos-ivp.org. It covers (a) a straw-man repository with a place-holder MOOS application and IvP Behavior, with a working CMake build structure, (b) a brief overview of the MOOS application class with an example application, (c) an overview of the IvP Behavior class with an example behavior, and (d) the IvPBuild Toolbox for generation of objective functions within behaviors

A Tour of MOOS-IvP Autonomy Software Modules

This paper provides an overview of the MOOS-IvP autonomy software modules. The MOOS-IvP collection of software, i.e., codebase, described here has been developed and is currently maintained by three organizations - Oxford University, Massachusetts Institute of Technology (MIT), and the Naval Undersea Warfare Center (NUWC) Division Newport Rhode Island. The objective of this paper is to provide a comprehensive list of modules and provide for each (a) a general description of functionality, (b) dependency relationships to other modules, (c) rough order of magnitude in complexity or size, (d) authorship, and (e) current and planned distribution access

Kiloparsec-scale Spatial Offsets in Double-peaked Narrow-line Active Galactic Nuclei. I. Markers for Selection of Compelling Dual Active Galactic Nucleus Candidates

Merger-remnant galaxies with kpc-scale separation dual active galactic nuclei (AGNs) should be widespread as a consequence of galaxy mergers and triggered gas accretion onto supermassive black holes, yet very few dual AGNs have been observed. Galaxies with double-peaked narrow AGN emission lines in the Sloan Digital Sky Survey are plausible dual AGN candidates, but their double-peaked profiles could also be the result of gas kinematics or AGN-driven outflows and jets on small or large scales. To help distinguish between these scenarios, we have obtained spatial profiles of the AGN emission via follow-up long-slit spectroscopy of 81 double-peaked narrow-line AGNs in SDSS at 0.03 < z < 0.36 using Lick, Palomar, and MMT Observatories. We find that all 81 systems exhibit double AGN emission components with ~kpc projected spatial separations on the sky, which suggests that they are produced by kpc-scale dual AGNs or kpc-scale outflows, jets, or rotating gaseous disks. In addition, we find that the subsample (58%) of the objects with spatially compact emission components may be preferentially produced by dual AGNs, while the subsample (42%) with spatially extended emission components may be preferentially produced by AGN outflows. We also find that for 32% of the sample the two AGN emission components are preferentially aligned with the host galaxy major axis, as expected for dual AGNs orbiting in the host galaxy potential. Our results both narrow the list of possible physical mechanisms producing the double AGN components, and suggest several observational criteria for selecting the most promising dual AGN candidates from the full sample of double-peaked narrow-line AGNs. Using these criteria, we determine the 17 most compelling dual AGN candidates in our sample.Comment: 12 pages, 8 figures, published in ApJ. Modified from original version to reflect referee's comment

An Overview of MOOS-IvP and a Brief Users Guide to the IvP Helm Autonomy Software

This document describes the IvP Helm - an Open Source behavior-based autonomy application for unmanned vehicles. IvP is short for interval programming - a technique for representing and solving multi-objective optimizations problems. Behaviors in the IvP Helm are reconciled using multi-objective optimization when in competition with each other for influence of the vehicle. The IvP Helm is written as a MOOS application where MOOS is a set of Open Source publish-subscribe autonomy middleware tools. This document describes the configuration and use of the IvP Helm, provides examples of simple missions and information on how to download and build the software from the MOOS-IvP server at www.moosivp.org

Photoactivatable genetically encoded calcium indicators for targeted neuronal imaging.

Circuit mapping requires knowledge of both structural and functional connectivity between cells. Although optical tools have been made to assess either the morphology and projections of neurons or their activity and functional connections, few probes integrate this information. We have generated a family of photoactivatable genetically encoded Ca(2+) indicators that combines attributes of high-contrast photolabeling with high-sensitivity Ca(2+) detection in a single-color protein sensor. We demonstrated in cultured neurons and in fruit fly and zebrafish larvae how single cells could be selected out of dense populations for visualization of morphology and high signal-to-noise measurements of activity, synaptic transmission and connectivity. Our design strategy is transferrable to other sensors based on circularly permutated GFP (cpGFP)