Snowmass Topical Group Summary Report: IF07 -- ASICs and Electronics

This writeup summarizes the work of the Topical Working Group 7 of the Instrumentation Frontier group of the Snowmass 2021 process. Group 'IF07' dealt with issues pertaining to ASICs and Readout Electronics. The community efforts as part of IF07 were organized across 7 white papers submitted to the Snowmass process and available in the arXiv.Comment: arXiv admin note: substantial text overlap with arXiv:2209.1411

Honors and Non-Honors Student Engagement: A Model of Student, Curricular, and Institutional Characteristics

Honors administrators may ask whether honors experiences facilitate student growth and whether honors students are inherently smarter than non-honors students and hence more able to seize these opportunities for growth. Although these questions will never fully be answered, we designed the current study to address the underlying topics of student characteristics and engagement in honors within the larger university. Students’ motivation, their willingness to extend beyond the minimal level, significantly influences engagement. Honors students are engaged in experiences, curricular and extracurricular, that promote development, and the types of additional opportunities available to honors students and the feedback they receive affect participation. The interaction between honors students and their instructional environment may encourage them to engage with available resources more fully than non-honors students do

Honors and Non-Honors Student Engagement: A Model of Student, Curricular, and Institutional Characteristics

Honors administrators may ask whether honors experiences facilitate student growth and whether honors students are inherently smarter than non-honors students and hence more able to seize these opportunities for growth. Although these questions will never fully be answered, we designed the current study to address the underlying topics of student characteristics and engagement in honors within the larger university. Students’ motivation, their willingness to extend beyond the minimal level, significantly influences engagement. Honors students are engaged in experiences, curricular and extracurricular, that promote development, and the types of additional opportunities available to honors students and the feedback they receive affect participation. The interaction between honors students and their instructional environment may encourage them to engage with available resources more fully than non-honors students do

Honors and Non-Honors Student Engagement: A Model of Student, Curricular, and Institutional Characteristics

Honors administrators may ask whether honors experiences facilitate student growth and whether honors students are inherently smarter than non-honors students and hence more able to seize these opportunities for growth. Although these questions will never fully be answered, we designed the current study to address the underlying topics of student characteristics and engagement in honors within the larger university. Students’ motivation, their willingness to extend beyond the minimal level, significantly influences engagement. Honors students are engaged in experiences, curricular and extracurricular, that promote development, and the types of additional opportunities available to honors students and the feedback they receive affect participation. The interaction between honors students and their instructional environment may encourage them to engage with available resources more fully than non-honors students do

Association of C-reactive protein and metabolic risk with cognitive effects of lurasidone in patients with schizophrenia

BACKGROUND: Accumulating evidence has implicated insulin resistance and inflammation in the pathophysiology of cognitive impairments associated with neuropsychiatric disorders. This post-hoc analysis based on a placebo-controlled trial investigated the effect of inflammation (indexed by CRP) and metabolic risk factors on cognitive performance in patients with schizophrenia treated with lurasidone. METHODS: Acutely exacerbated patients with schizophrenia were randomized to lurasidone (80 or 160 mg/day), quetiapine XR 600 mg/day, or placebo. A wide range CRP test and a cognitive assessment using the CogState computerized battery were performed at baseline and week 6 study endpoint. Associations between log-transformed CRP, high density lipoprotein (HDL), homeostatic model assessment of insulin resistance (HOMA-IR) and treatment response were evaluated. RESULTS: CRP combined with HDL, triglyceride-to-HDL (TG/HDL) ratio, or HOMA-IR at study baseline were significant moderators of the improvement in cognitive performance associated with lurasidone 160 mg/day (vs. placebo) treatment (p \u3c .05). Greater placebo-corrected treatment effect size on the CogState composite score was observed for patients in the lurasidone 160 mg/day treatment group who had either low CRP and high HDL (d = 0.43), or low CRP and low HOMA-IR (d = 0.46). Interactive relationships between CRP, HDL, TG/HDL, HOMA-IR and the antipsychotic efficacy of lurasidone or quetiapine XR were not significant. There were no significant associations between antipsychotic treatment and changes in CRP level at study endpoint. CONCLUSIONS: Findings of this post-hoc analysis based on a placebo-controlled trial in patients with schizophrenia suggest that baseline CRP level combined with measures of metabolic risk significantly moderated the improvement in cognitive performance associated with lurasidone 160 mg/day (vs. placebo) treatment. Our findings underscore the importance of maintaining a low metabolic risk profile in patients with schizophrenia

Using Innovation-Corps (I-Corps™) methods to adapt a mobile health (mHealth) obesity treatment for community mental health settings

BACKGROUND: We employed Innovation Corps (I-Corps™) methods to adaptation of a mobile health (mHealth) short-message-system (SMS) -based interactive obesity treatment approach (iOTA) for adults with severe mentall illness receiving care in community settings. METHODS: We hypothesized jobs to be done in three broad stakeholder groups: decision makers (DM = state and community clinic administrators), clinician consumers (CC = case managers, peer supports, nurses, prescribers) and service consumers (SC = patients, peers and family members). Semistructured interviews ( RESULTS: Four themes emerged across groups: education, inertia, resources and ownership. Sub-themes in education and ownership differed between DM and CC groups on implementation ownership, intersecting with professional development, suggesting the importance of training and supervision in scalability. Sub-themes in resources and intertia differed between CC and SC groups, suggesting illness severity and access to healthy food as major barriers to engagement, whereas the SC group identified the need for enhanced emotional support, in addition to pragmatic skills like menu planning and cooking, to promote health behavior change. Although SMS was percieved as a viable education and support tool, CC and DM groups had limited familiarity with use in clinical care delivery. CONCLUSIONS: Based on customer discovery, the characteristics of a minimum viable iOTA for implementation, scalability and sustainability include population- and context-specific adaptations to treatment content, interventionist training and delivery mechanism. Successful implementation of an SMS-based intervention will likely require micro-adaptations to fit specific clinical settings