Solid-state switching used to speed up capacitive integrator

Capacitive integrator circuit using Silicon Controlled Switches /SCS/ insures output voltage linearly proportional to input pulse width. This circuit provides high input impedance and relatively low output impedance

Variable duration pulse integrator Patent

Variable duration pulse integrator design for integrating pulse duration modulated pulses with elimination of ripple conten

Variable width pulse integrator Patent

Solid state integrator for converting variable width pulses into analog voltag

Attitude sensor

A device for controlling the attitude of a spacecraft is described. The device consists of two light sensors on a spacecraft that are mounted beneath a baffle which divides the light from a light source such as the sun or a star. The divided light reflects off of two reflective surfaces onto the two light sensors. When the spacecraft assumes its normal attitude, the baffle divides the light source into two equal parts, causing the two light sensors to produce equal outputs. When the light is equally detected, the stabilizing system is disconnected. Deviations from the normal attitude cause unequal distribution of the light source and energize the stabilizing system

A carbon fiber exposure test facility and instrumentation

A facility to evaluate the risk associated with the exposure of electrical and electronic equipment to airborne carbon/graphite fibers was constructed. A wide variety of instrumentation is described and illustrated

Electromagnetic mirror drive system

Oscillatory electromagnetic mirror drive system for horizon scanner

The Effect of Voids in Mineral Aggregate (VMA) on Hot-Mix Asphalt Pavements

This research project investigates the level of Voids in the Mineral Aggregate (VMA) in Minnesota paving projects. Researchers analyzed 10 paving projects from 1996 to determine if a VMA decrease occurred, the magnitude of the de =crease, and the potential causes of the decrease. Potential causes include the generation of fines, high-production temperatures, and long storage or cure times. Three of the 10 projects had a VMA decrease of 1.9 or more. These three projects also had the highest plant temperatures and fairly long storage times, which makes increased asphalt absorption a likely cause of the VMA decrease. Five projects showed a moderate drop in VMA. Most had some increases in fines, and some had moderately high plant temperatures and storage times. The two projects with little or no changes in VMA had very little change in gradation, and moderate to low plant temperatures and storage times

The Endogenous Th17 Response in NO<inf>2</inf>-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer

Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease. Nitrogen dioxide (NO2) is an environmental toxin that correlates with asthma severity, exacerbation, and risk of adverse outcomes. Mice that are allergically sensitized to the antigen ovalbumin by exposure to NO2 exhibit a mixed Th2/Th17 adaptive immune response and eosinophil and neutrophil recruitment to the airway following antigen challenge, a phenotype reminiscent of severe clinical asthma. Because IL-1 receptor (IL-1R) signaling is critical in the generation of the Th17 response in vivo, we hypothesized that the IL-1R/Th17 axis contributes to pulmonary inflammation and airway hyperresponsiveness (AHR) in NO2-promoted allergic airway disease and manifests in glucocorticoid-resistant cytokine production. IL-17A neutralization at the time of antigen challenge or genetic deficiency in IL-1R resulted in decreased neutrophil recruitment to the airway following antigen challenge but did not protect against the development of AHR. Instead, IL-1R-/- mice developed exacerbated AHR compared to WT mice. Lung cells from NO2-allergically inflamed mice that were treated in vitro with dexamethasone (Dex) during antigen restimulation exhibited reduced Th17 cytokine production, whereas Th17 cytokine production by lung cells from recipient mice of in vitro Th17-polarized OTII T-cells was resistant to Dex. These results demonstrate that the IL-1R/Th17 axis does not contribute to AHR development in NO2-promoted allergic airway disease, that Th17 adoptive transfer does not necessarily reflect an endogenously-generated Th17 response, and that functions of Th17 responses are contingent on the experimental conditions in which they are generated. © 2013 Martin et al