138 research outputs found
Monte Carlo Exploration of Warped Higgsless Models
We have performed a detailed Monte Carlo exploration of the parameter space
for a warped Higgsless model of electroweak symmetry breaking in 5 dimensions.
This model is based on the gauge group
in an AdS bulk with arbitrary gauge kinetic terms on both the Planck and
TeV branes. Constraints arising from precision electroweak measurements and
collider data are found to be relatively easy to satisfy. We show, however,
that the additional requirement of perturbative unitarity up to the cut-off,
TeV, in elastic scattering in the absence of dangerous
tachyons eliminates all models. If successful models of this class exist, they
must be highly fine-tuned.Comment: 26 pages, 7 figures; new fig and additional text adde
Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed
Genetic studies on telomere length are important for understanding age-related diseases. Prior GWASs for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally diverse individuals (European, African, Asian, and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole-genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n = 109,122 individuals. We identified 59 sentinel variants (p < 5 × 10−9) in 36 loci associated with telomere length, including 20 newly associated loci (13 were replicated in external datasets). There was little evidence of effect size heterogeneity across populations. Fine-mapping at OBFC1 indicated that the independent signals colocalized with cell-type-specific eQTLs for OBFC1 (STN1). Using a multi-variant gene-based approach, we identified two genes newly implicated in telomere length, DCLRE1B (SNM1B) and PARN. In PheWAS, we demonstrated that our TL polygenic trait scores (PTSs) were associated with an increased risk of cancer-related phenotypes
Passive Q-switching and mode-locking for the generation of nanosecond to femtosecond pulses
Competition and the performance of strategic business units ‐ A study of the South African beverage industry
Workplace safety regulations and worker well-being: the impact of mandatory helmet use on career length in the national hockey league
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