Landscape into Legend: Tracking Lost Tribes and Crypto-Jews across New Mexican Terrain

The essay traces the “Lost Tribes of Israel” legend to the purported academic discovery of lost and hidden “crypto-Jews” in contemporary New Mexico. The essay explores perceptions and beliefs of Jewish diasporic survival and identity in folkloristic, religious, historical, and genomic contexts. Analysis exposes pseudo-ethnography and pseudoscience as the basis for New Mexican claims, influenced in part by habitual association of the regional landscape with lost, hidden, and/or “wandering” Jews

Análisis de la transparencia activa en el senado y el tribunal de cuentas de España (2017)

Depto. de Ciencia Política y de la AdministraciónFac. de Ciencias Políticas y SociologíaTRUEunpu

Structural effects of linkage disequilibrium on the transcriptome

A majority of SNPs (single nucleotide polymorphisms) map to noncoding and intergenic regions of the genome. Noncoding SNPs are often identified in genome-wide association studies (GWAS) as strongly associated with human disease. Two such disease-associated SNPs in the 5′ UTR of the human FTL (Ferritin Light Chain) gene are predicted to alter the ensemble of structures adopted by the mRNA. High-accuracy single nucleotide resolution chemical mapping reveals that these SNPs result in substantial changes in the structural ensemble in agreement with the computational prediction. Furthermore six rescue mutations are correctly predicted to restore the mRNA to its wild-type ensemble. Our data confirm that the FTL 5′ UTR is a “RiboSNitch,” an RNA that changes structure if a particular disease-associated SNP is present. The structural change observed is analogous to that of a bacterial Riboswitch in that it likely regulates translation. These data further suggest that specific pairs of SNPs in high linkage disequilibrium (LD) will form RNA structure-stabilizing haplotypes (SSHs). We identified 484 SNP pairs that form SSHs in UTRs of the human genome, and in eight of the 10 SSH-containing transcripts, SNP pairs stabilize RNA protein binding sites. The ubiquitous nature of SSHs in the transcriptome suggests that certain haplotypes are conserved to avoid RiboSNitch formation

Tutor and teacher timescapes : lessons from a home-school partnership

A partnership project was developed in which parents volunteered to support teachersin training years 1-3 children in computer skills at a primary school in a small, lowsocio-economic community. This article identifies the ways teachers and the &lsquo;tutors&rsquo;(as the volunteers were called) understood the value of the project. &lsquo;Being a teacher&rsquo;and &lsquo;being a volunteer&rsquo; were structured by different forms of social engagement,which in turn influenced the ways individuals were able to work with each other incollaborative processes. We argue that the discursive practices encoded in homeschool-community partnership rhetoric represent ruling-class ways of organising andnetworking that may be incompatible with those of people from low socio-economicbackgrounds. When such volunteers work in schools their attendance may be sporadicand short-term whereas teachers would like &lsquo;reliable&rsquo; ongoing commitment. Thismismatch wrought of teachers&rsquo; and volunteers&rsquo; differing everyday realities needs to beunderstood before useful models for partnerships in disadvantaged communities maybe realised.<br /

Sharing and archiving nucleic acid structure mapping data

Nucleic acids are particularly amenable to structural characterization using chemical and enzymatic probes. Each individual structure mapping experiment reveals specific information about the structure and/or dynamics of the nucleic acid. Currently, there is no simple approach for making these data publically available in a standardized format. We therefore developed a standard for reporting the results of single nucleotide resolution nucleic acid structure mapping experiments, or SNRNASMs. We propose a schema for sharing nucleic acid chemical probing data that uses generic public servers for storing, retrieving, and searching the data. We have also developed a consistent nomenclature (ontology) within the Ontology of Biomedical Investigations (OBI), which provides unique identifiers (termed persistent URLs, or PURLs) for classifying the data. Links to standardized data sets shared using our proposed format along with a tutorial and links to templates can be found at http://snrnasm.bio.unc.edu

Rendering generalized cylinders using the A-buffer

grantor: University of TorontoA variety of objects modelled in computer graphics can be efficiently approximated with generalized cylinders, particularly when they are viewed at a relatively small scale. In this thesis we present a unique way of rendering generalized cylinders using polygon-based projective rendering: a rendering meta-primitive called the paintstroke. Paintstrokes allow for the concise modelling and efficient dynamic tessellation of generalized cylinders, making direct use of their screen-space projections so as to minimize the number of polygons required to construct their images. The resulting savings in vertex transformations, rasterization overhead, and edge antialiasing more than repay the cost of the tessellation. Used in conjunction with our A-Buffer polygon renderer, paintstrokes achieve a good balance of speed and image quality when drawn at small to medium scales, generally surpassing other methods for rendering generalized cylinders.M.Sc

Review of 'Hand Trembling, Frenzy Witchcraft, and Moth Madness: A Study of Navajo Seizure Disorders' (Levy, Neutra, and Parker)

Review