ОНКОЛИТИЧЕСКИЕ ПАРВОВИРУСЫ. НОВЫЕ ПОДХОДЫ К ЛЕЧЕНИЮ РАКОВЫХ ЗАБОЛЕВАНИЙ

Parvoviruses such as parvovirus H-1 (H-1PV) may selectively infect and lysis cancer cells. The parvoviruses also induce an immune system to eliminate the tumor cells through the formation of anti-cancer immunity. One of the possible mechanisms of antitumor activity is associated with the direct induction of apoptosis by parvoviral proteins NS1 and 11 kDa. Parvovirus-based vectors are promising for gene therapy of oncological diseases and genetic disorders in humans. Parvoviruses were successfully used for the experimental treatment on animal models of human glioma, neuroblastomas, lymphomas, pancreatic carcinoma, carcinomas and breast tumors. ParvOryx is the first oncolytic preparation constructed on the base of H-1PV; its phase I/IIa clinical trials in patients with glioblastoma multiforme are in process.Парвовирусы, и прежде всего парвовирус H-1 (H-1PV), способны селективно инфицировать и лизировать клетки раковых опухолей. При этом парвовирусы вызывают иммуномодулирующий эффект, приводя к элиминации опухолевых клеток посредством усиления противоракового иммунитета. Один из возможных механизмов противоопухолевого действия связан с прямой индукцией апоптоза белками 11кДа и NS1 парвовирусов. Векторные системы на основе генома парвовирусов также перспективны для генной терапии различных онкологических и генетических заболеваний человека. Парвовирусы были успешно использованы для экспериментального лечения глиомы, нейробластомы, лимфомы, гепатомы, карциномы поджелудочной железы и опухолей молочной железы человека в экспериментах на животных. Первый онколитический препарат ParvOryx на основе парвовируса H-1 проходит клинические испытания фазы I/IIa на пациентах c мультиформной глиобластомой

ВСПЫШКА ОСТРОЙ КИШЕЧНОЙ ИНФЕКЦИИ ЭНТЕРОВИРУСНОЙ ЭТИОЛОГИИ В САХАЛИНСКОЙ ОБЛАСТИ В АВГУСТЕ 2010 ГОДА

The investigation of cases of acute intestinal infections in the Sakhalin region of Russia in August, 2010 is described. Epidemiological and molecular biological studies were conducted. After initial PCR screening and determining the nucleotide sequences of the positive samples the following enteroviruses were found: Coxsackie A2 — 42 samples (45%), Coxsackie A4 — 31 sample (34%), Enterovirus 71 — 6 samples (6,5%), Coxsackievirus B5 — 6 samples (6,5%), Coxsackie B3 — 4 samples (4%) and Coxsackie B1 — 4 samples (4%). The phylogenetic analysis of sequences showed that the closest analogues for the nucleotide sequences of these genotypes were previously identified in Japan, Korea and China in 2000–2010.В данной статье описано расследование случаев острой кишечной инфекции (ОКИ), зарегистрированных в Сахалинской области в августе 2010 г. Проведены эпидемиологические и молекулярно-биологические исследования. После скринингового ПЦР-исследования на различные возбудители ОКИ и определения нуклеотидных последовательностей в положительных образцах были идентифицированы энтеровирусы: Коксаки А2 — 42 образца (45%), Коксаки А4 — 31 образец (34%), энтеровирус 71 — 6 образцов (6,5%), Коксаки В5 — 6 образцов (6,5%), Коксаки В3 — 4 образца (4%) и Коксаки В1 — 4 образца (4%). Филогенетический анализ показал, что наиболее близкие по нуклеотидным последовательностям прототипы этих генотипов уже выявлены в Японии, Корее и Китае в 2000–2010 гг

Taxonomy of the order Mononegavirales: update 2016

In 2016, the order Mononegavirales was emended through the addition of two new families (Mymonaviridae and Sunviridae), the elevation of the paramyxoviral subfamily Pneumovirinae to family status (Pneumoviridae), the addition of five free-floating genera (Anphevirus, Arlivirus, Chengtivirus, Crustavirus, and Wastrivirus), and several other changes at the genus and species levels. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV)

The VP35 and VP40 proteins of filoviruses Homology between Marburg and Ebola viruses

AbstractThe fragments of genomic RNA sequences of Marburg (MBG) and Ebola (EBO) viruses are reported. These fragments were found to encode the VP35 and VP40 proteins. The canonic sequences were revealed before and after each open reading frame. It is suggested that these sequences are mRNA extremities and at the same time the regulatory elements for mRNA transcription. Homology between the MBG and EBO proteins was discovered

Taxonomy of the order Mononegavirales: Second update 2018

In October 2018, the order Mononegavirales was amended by the establishment of three new families and three new genera, abolishment of two genera, and creation of 28 novel species. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV)

Taxonomy of the order Mononegavirales: update 2019

In February 2019, following the annual taxon ratification vote, the order Mononegavirales was amended by the addition of four new subfamilies and 12 new genera and the creation of 28 novel species. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV)