15 research outputs found
MIMIC-Extract: A Data Extraction, Preprocessing, and Representation Pipeline for MIMIC-III
Robust machine learning relies on access to data that can be used with
standardized frameworks in important tasks and the ability to develop models
whose performance can be reasonably reproduced. In machine learning for
healthcare, the community faces reproducibility challenges due to a lack of
publicly accessible data and a lack of standardized data processing frameworks.
We present MIMIC-Extract, an open-source pipeline for transforming raw
electronic health record (EHR) data for critical care patients contained in the
publicly-available MIMIC-III database into dataframes that are directly usable
in common machine learning pipelines. MIMIC-Extract addresses three primary
challenges in making complex health records data accessible to the broader
machine learning community. First, it provides standardized data processing
functions, including unit conversion, outlier detection, and aggregating
semantically equivalent features, thus accounting for duplication and reducing
missingness. Second, it preserves the time series nature of clinical data and
can be easily integrated into clinically actionable prediction tasks in machine
learning for health. Finally, it is highly extensible so that other researchers
with related questions can easily use the same pipeline. We demonstrate the
utility of this pipeline by showcasing several benchmark tasks and baseline
results
The Science Performance of JWST as Characterized in Commissioning
This paper characterizes the actual science performance of the James Webb
Space Telescope (JWST), as determined from the six month commissioning period.
We summarize the performance of the spacecraft, telescope, science instruments,
and ground system, with an emphasis on differences from pre-launch
expectations. Commissioning has made clear that JWST is fully capable of
achieving the discoveries for which it was built. Moreover, almost across the
board, the science performance of JWST is better than expected; in most cases,
JWST will go deeper faster than expected. The telescope and instrument suite
have demonstrated the sensitivity, stability, image quality, and spectral range
that are necessary to transform our understanding of the cosmos through
observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures;
https://iopscience.iop.org/article/10.1088/1538-3873/acb29
Coastal bluffs in the Brooklin quadrangle, Maine
Maine Geological Survey, Open-File Map 02-178https://digitalmaine.com/mgs_maps/1485/thumbnail.jp
Evaluating the long-term biological stability of cytokine biomarkers in ocular fluid samples
Purpose The quality of biological fluid samples is vital for optimal preanalytical procedures and a requirement for effective translational biomarker research. This study aims to determine the effects of storage duration and freeze-thawing on the levels of various cytokines in the human aqueous humour and vitreous samples.Methods and analysis Human ocular aqueous humour and vitreous samples were obtained from 25 eyes and stored at −80°C for analysis. All samples were assayed for 27 cytokine biomarker concentrations (pg/mL) using a multiplex assay. Four sample storage durations following sample collection were evaluated (1 week, 3 months, 9 months and 15 months). Additionally, samples underwent up to three freeze-thaw cycles within the study period.Results Among the 27 cytokine biomarkers, concentrations of four cytokines (Interleukin (IL)−2, IL-10, IL-12 and platelet-derived growth factor-BB) were significantly decreased by storage duration at all time points, as early as 3 months following sample collection (range of 9%–37% decline between 1 week and 15 months, p<0.001). Freeze-thawing of up to three cycles did not significantly impact the cytokine biomarker concentrations in aqueous humour or vitreous. Separability of patient-specific cytokine biomarker profiles in the principal component analysis remained relatively the same over the 15 months of storage duration.Conclusion The findings from this study suggest that several intraocular cytokine biomarkers in human aqueous humour and vitreous samples may be susceptible to degradation with long-term storage, as early as 3 months after collection. The overall patient-specific cytokine biomarker profiles are more stable than concentrations of individual cytokines. Future studies should focus on developing guidelines for optimal and standardised sample handling methods to ensure correct research findings about intraocular biomarkers are translated into clinical practice