Il MOOC incontra la Gamification. Riflessioni su un’esperienza di progettazione di un MOOC su piattaforma EMMA

This paper derives from the analysis and the reflections emerged after the MOOC “Gamification in education. New ways to learn” in EMMA platform during winter 2016

Dire fare... baciare! Emozionarsi giocando

This paper promotes reflections about game as tool of emotional education. The game is search of emotions, emotions that only in the game express themselves, emotions that only in the game can be lived without fear. The paper focuses on the role of the adult and the design of the game environment

La corruzione del ludico: un rischio di oggi e un’emergenza educativa. Riflessioni pedagogico-didattiche

Using debate as an effective educational tool means choosing a suitable debate format for accomplishing the pedagogical aims we have in mind. Thus, the aim of this paper is to understand how each debate format relates to the competencies it promotes. It is only through knowing how competencies are stimulated by specific rules of debate formats that we are able to make a reasoned and effective choice

Lettura pedagogica di Essere e tempo di Martin Heidegger

The volume aims to highlight, through an accurate critical rereading, the possible pedagogical categories (even implicit) present within Heidegger's Being and Time. After examining the author in his path of life and thought, the attention is focused on the masterpiece of 1927: on its genesis and on its more strictly philosophical contents. In particular, some very important categories for a theory of the education of the person are examined (cure, being-in-the-world, death). Ample space is also given to the notion of authenticity as a possible - high, complex and regulatory - goal of education. Thus, she tried to see what are the "existentials" that can still guide us towards a careful anthropological-pedagogical reflection

A homozygous MRPL24 mutation causes a complex movement disorder and affects the mitoribosome assembly

Mitochondrial ribosomal protein large 24 (MRPL24) is 1 of the 82 protein components of mitochondrial ribosomes, playing an essential role in the mitochondrial translation process.We report here on a baby girl with cerebellar atrophy, choreoathetosis of limbs and face, intellectual disability and a combined defect of complexes I and IV in muscle biopsy, caused by a homozygous missense mutation identified in MRPL24. The variant predicts a Leu91Pro substitution at an evolutionarily conserved site. Using human mutant cells and the zebrafish model, we demonstrated the pathological role of the identified variant. In fact, in fibroblasts we observed a significant reduction of MRPL24 protein and of mitochondrial respiratory chain complex I and IV subunits, as well a markedly reduced synthesis of the mtDNA-encoded peptides. In zebrafish we demonstrated that the orthologue gene is expressed in metabolically active tissues, and that gene knockdown induced locomotion impairment, structural defects and low ATP production. The motor phenotype was complemented by human WT but not mutant cRNA. Moreover, sucrose density gradient fractionation showed perturbed assembly of large subunit mitoribosomal proteins, suggesting that the mutation leads to a conformational change in MRPL24, which is expected to cause an aberrant interaction of the protein with other components of the 39S mitoribosomal subunit