16 research outputs found

    Chromosomal mapping of murine c-fes and c-src genes

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    The murine homologs of two viral oncogenes associated with tyrosine-specific kinase activity have been assigned to different loci in the mouse genome. The segregation of restriction site polymorphisms, as detected by probes that are specific for endogenous c-fes and c-src sequences, was followed in the DNA of recombinant inbred strains. The c-fes gene was mapped to the proximal portion of chromosome 7, very close to the Gpi-1 locus, whereas c-src was linked to the Psp locus on the distal half of chromosome 2

    Cytological Identification of the Chromosomes Involved in Searle's Translocation and the Location of the Centromere in the X Chromosome of the Mouse

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    The autosome in Searle's X-autosome translocation has been shown to be chromosome 16. The breakpoint in chromosome 16 is slightly proximal to the middle and in the X is slightly distal to the middle.—Available evidence indicates that either Linkage Group XV or Linkage Group XIX is carried on chromosome 16.—The centromere of the X chromosome is at the spf end of the linkage group
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