82 research outputs found
Safety and Efficacy of Paracetamol + Lignocaine Injection in Patients with High-grade Fever:A Prospective Analysis
Paracetamol is frequently used as an analgesic and antipyretic across the world. However, there is no data on Indian patients regarding the safety and efficacy of paracetamol + lignocaine injection in patients with high-grade fever. Hence, a prospective analysis was conducted to assess the safety and efficacy of paracetamol and lignocaine injection in patients with high-grade fever and mild-to-moderate body pain. The study is a real-world prospective study. The results showed that following intervention with paracetamol and lignocaine injection, 98% patients showed resolution of fever and 58% patients showed improvement in pain symptoms. The authors suggest that clinicians should consider paracetamol and lignocaine injection in patients with high-grade fever and associated pain and discomfort
Studies on secondary metabolites of Som ( Persea bombycina Kost), a primary host plant of muga silkworm (Antheraea assamensis Helfer)
The host plant selection behaviour or feeding preferences of the insects are largely mediated by the
presence and distribution of secondary metabolites in plants. Quantitative estimation of few secondary metabolites and
HPLC analysis of phenolic compounds were carried out from the leaves of Som plant (Persea bombycina Kost) which is
a primary metabolite of the shimmering yellow golden silk yarn producer, the muga silkworm (Antheraea assamensis
Helfer). β –sitosterol content in the tender leaves was significantly the highest (1.06%) over semi-mature or mature
leaves, whereas Chlorogenic acid content was more in medium leaves (2.06%). Phytic acid content was significantly
higher in mature leaves (2310.05 mg/100g), total phenol in tender leaves (1.946%), ADF in mature leaves (26.50%),
ADL in mature leaves and tannin in tender leaves (6.71%). Purified phenolic extract when subjected to HPLC analysis, 6
prominent peaks were observed and screening with standard indicates Peaks 1, 2, 3 and 6 correspond to Chlorogenic
acid, catechol, Morin and gallic acid, respectively.
Keywords: Som, Persea bombycina, Muga silkworm, Antheraea assamensis, secondary metabolites, HPLC analysis
Analysis of Genetic Diversity of Persea bombycina ‘‘Som’’ Using RAPD-Based Molecular Markers
The utility of RAPD markers in assessing genetic diversity and phenetic
relationships in Persea bombycina, a major tree species for golden silk (muga)
production, was investigated using 48 genotypes from northeast India. Thirteen
RAPD primer combinations generated 93 bands. On average, seven RAPD fragments
were amplified per reaction. In a UPGMA phenetic dendrogram based on
Jaccard’s coefficient, the P. bombycina accessions showed a high level of genetic
variation, as indicated by genetic similarity. The grouping in the phenogram was
highly consistent, as indicated by high values of cophenetic correlation and high
bootstrap values at the key nodes. The accessions were scattered on a plot derived
from principal correspondence analysis. The study concluded that the high level of
genetic diversity in the P. bombycina accessions may be attributed to the species’
outcrossing nature. This study may be useful in identifying diverse genetic stocks of
P. bombycina, which may then be conserved on a priority basis
Studies on the influence of host plants and effect of chemical stimulants on the feeding behavior in the muga silkworm, Antheraea assamensis
The feeding habits of Antheraea assamensis, Helfer (Lepidoptera: Saturniidae) larvae towards the
leaves of its four different host plants, Persea bombycina King ex. Hook (Laurales: Lauraceae),
Litsea polhantha Jussieu, L. salicifolia Roxburgh ex. Nees and L. citrata Blume, and the
chemical basis of feeding preference were investigated. Nutritional superiority of young and
medium leaves with respect to soluble protein, total phenol and phenylalanine ammonia lyase
activity was observed in the leaves of P. bombycina compared to other host plants. Attraction and
feeding tests with detached leaves and artificial diet with different chemical stimulants revealed
that a mixture of the flavonoids, myrcetin, and 7, 2’, 4’ trimethoxy dihydroxy flavone with sterol
compound β-sitosterol elicited the most biting behavior by A. assamensis larvae. While linalyl
acetate alone attracted larvae towards the leaves of the host plants, a mixture of caryophyllene,
decyl aldehyde and dodecyl aldehyde was found to both attract them to the host leaves and cause
biting behavior. Azaindole was found to deter them from the host plants
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