PSTVd RNA structures.

<p>(A) The 2D organization of PSTVd RNA genome. 3D structural arrangements and the function of loop 6, loop 7, and loop E are listed [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006801#ppat.1006801.ref017" target="_blank">17</a>–<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006801#ppat.1006801.ref019" target="_blank">19</a>]. “T” and “R” depict the functions in “trafficking” and “replication,” respectively [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006801#ppat.1006801.ref016" target="_blank">16</a>]. (B) Disruptive and compensatory PSTVd loop E mutants predicted by isostericity [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006801#ppat.1006801.ref017" target="_blank">17</a>]. Illustration for the replication of PSTVd variants in tomato plants, verified by northern blots [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006801#ppat.1006801.ref017" target="_blank">17</a>], is shown in the lower panel. PSTVd, potato spindle tuber viroid; WT, wild-type.</p

Top, Watson–Crick G/U (wobble) basepair with water molecules (W) in its SGP and DGP

<p><b>Copyright information:</b></p><p>Taken from "Structural and evolutionary classification of G/U wobble basepairs in the ribosome"</p><p>Nucleic Acids Research 2006;34(5):1326-1341.</p><p>Published online 6 Mar 2006</p><p>PMCID:PMC1390688.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> The angles formed between the C1′–C1′ axis and the glycosidic bonds show the asymmetry of this basepair compared with the classical WC basepairs. Bottom, the isosteric A/C basepair. Produced by ChemDraw (CambridgeSoft Corporation)