UTB/TSC Commencement – Winter 1997

https://scholarworks.utrgv.edu/brownsvillelegacycommencement/1021/thumbnail.jp

Genetics update: monogenetics, polygene disorders and the quest for modifying genes

The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships. In this review we give an overview of the factors that influence genotype-phenotype relationships across this group of diseases as a whole, using specific individual channelopathies as examples. We suggest reasons for the limitations observed in these relationships. We discuss the role of ion channel variation in polygenic disease and highlight research that has contributed to unravelling the complex aetiological nature of these conditions. We focus specifically on the quest for modifying genes in inherited channelopathies, using the voltage-gated sodium channels as an example. Epilepsy related to genetic channelopathy is one area in which precision medicine is showing promise. We will discuss the successes and limitations of precision medicine in these conditions

UTB/TSC Commencement – Spring 1994

https://scholarworks.utrgv.edu/brownsvillelegacycommencement/1018/thumbnail.jp

UTB/TSC Commencement – Spring 2009

https://scholarworks.utrgv.edu/brownsvillelegacycommencement/1040/thumbnail.jp

UTB/TSC Commencement – Winter 2011

https://scholarworks.utrgv.edu/brownsvillelegacycommencement/1008/thumbnail.jp

UTRGV Commencement – Fall 2022

https://scholarworks.utrgv.edu/utrgvcommencement/1014/thumbnail.jp

UTB/TSC Commencement – Spring 1992

https://scholarworks.utrgv.edu/brownsvillelegacycommencement/1016/thumbnail.jp

UTB/TSC Commencement – Spring 2012

https://scholarworks.utrgv.edu/brownsvillelegacycommencement/1009/thumbnail.jp

UTB/TSC Commencement – Spring 2011

https://scholarworks.utrgv.edu/brownsvillelegacycommencement/1007/thumbnail.jp