Honored

he Board of Directors of the Association of Christian Librarians honored an unsung hero when it selected Stephen P. Brown to receive the 1999 Emily Russel Award. While his contributions to ACL may be unknown by many, they are certainly known and appreciated by those who have been involved in the leadership of this Association anytime in the last twenty plus years. Perhaps no one knows all of the things he has done behind the scenes to keep this Association functioning and viable

The Christian Periodical Index, ACL’s Longest Service Project

When the Christian Librarians’ Fellowship (CLF) was first formed in 1956, those early librarians were not just focused on their own needs, but they were also concerned with the information needs of students at Christian institutions. Part of their earliest vision was the establishment of the Christian Periodical Index (CPI).And so began a project which continues to the present day. It has far exceeded anyone’s vision at the time if its creation. Who knew about the coming explosion of publishing – to say nothing about the Internet! Yet the mission of CPI – to provide access to English language articles and reviews from an evangelical perspective – has not changed in 50 years, though it has broadened its target group from the original CLF membership

ACL and God’s Call to Librarianship

Many people have asked me how, as a librarian in a secular institution, I became so involved in ACL. I have been at Auburn University Libraries since 1978, but before that was at a Christian liberal arts college, now defunct. ACL has been part of my life since the early 70’s and, of all the professional organizations to which I have belonged, it is the one that has had the greatest effect on me personally

Defining Roles of Metabolic Reprogramming in Pancreatic Tumorigenesis and Tumor Maintenance

Pancreatic cancer is the third leading cause of cancer-related deaths in the United States. Nearly all pancreatic tumors harbor mutations in oncogenic KRAS. Unfortunately, KRAS is difficult to target therapeutically, despite decades of efforts. As such, KRAS-dependent pathways remain promising targets for the development of new therapeutics. Pancreatic cancer extensively reprograms cellular metabolism to support uncontrolled growth and proliferation. Mutations in oncogenic KRAS drive metabolic rewiring that PDA cells are dependent on to supply biosynthetic precursors and energy. Understanding the metabolic dependencies of tumorigenesis and tumor maintenance could reveal targetable vulnerabilities for disease detection and/or treatment. Acinar cells can give rise to pancreatic tumors through acinar-to-ductal metaplasia (ADM), and inhibiting pathways that maintain acinar homeostasis can accelerate tumorigenesis. During ADM, acinar cells transdifferentiate to duct-like cells, a process driven by oncogenic KRAS, and one that we hypothesized was mediated by metabolic rewiring. Transcriptomic analysis revealed global enhancement of metabolic programs in acinar cells undergoing ADM. We previously demonstrated that pancreatic cancer cells rewire glucose and glutamine metabolism to support growth and survival. Using in vitro models of ADM, we found that glutamine availability is not required for ADM. In contrast, glucose availability and intact oxidative phosphorylation are required for ADM. A more detailed analysis of the pathways downstream of glucose metabolism revealed that disrupting the oxidative pentose phosphate pathway accelerates ADM in vitro and tumorigenesis in vivo, likely due to heightened oxidative stress. Changes in redox balance can attenuate or accelerate ADM in vitro and in vivo. Redox homeostasis is also tightly regulated in pancreatic cancer cells by rewiring glutamine metabolism through a glutamate oxaloacetate transaminase 1 (GOT1)-dependent pathway. GOT1 inhibition disrupts redox homeostasis in pancreatic cancer cells. These insights were leveraged in PDA, where we demonstrate that radiotherapy potently enhanced the effect of GOT1 inhibition on tumor growth. Understanding the metabolic pathways that contribute to pancreatic tumorigenesis and tumor maintenance, such as redox homeostasis, could provide biomarkers for diagnosis of early disease or development of better therapeutics for treating pancreatic cancer.PHDCancer BiologyUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/163123/1/barbnels_1.pd

Getting on Nicely in the Dark: The Perils and Rewards of Annotating Ulysses

The problem of how to provide useful contextual and extra-textual information to readers of Ulysses has vexed Joyceans for years. The debate has generated lively and opinionated discussions in print and at Joyce meetings, forums and listservs. On one side are scholars who argue for scaled-down annotations that present only basic information as simply as possible, minimizing the amount of interpretation involved. On the other side are the actual first-time readers, struggling to make sense of Joyce’s complex, highly allusive text, and willing to accept help wherever it may be found. The work of annotation is both complicated and enriched when it is undertaken in a hypermedia environment. This thesis addresses these issues, particularly as they relate to the task of annotating a list of characters in the novel for The Joyce Project, a hypermedia version of Ulysses under the direction of Professor John Hunt at the University of Montana. With brief entries for more than 180 characters, the list is intended primarily as an aid to help readers keep track of the dozens of characters who inhabit the pages of Joyce’s work. However, creating the list in hypermedia, with links between characters in the list, between the text and the list, and between the text and external sources, creates a virtual web of connections which leads to new insights and directions for further study

Predictive factors for ovarian response in a corifollitropin alfa/GnRH antagonist protocol for controlled ovarian stimulation in IVF/ICSI cycles

Background This secondary analysis aimed to identify predictors of low (<6 oocytes retrieved) and high ovarian response (>18 oocytes retrieved) in IVF patients undergoing controlled ovarian stimulation with corifollitropin alfa in a gonadotropin-releasing hormone (GnRH) antagonist protocol. Methods Statistical model building for high and low ovarian response was based on the 150 μg corifollitropin alfa treatment group of the Pursue trial in infertile women aged 35–42 years (n = 694). Results Multivariable logistic regression models were constructed in a stepwise fashion (P <0.05 for entry). 14.1 % of subjects were high ovarian responders and 23.2 % were low ovarian responders. The regression model for high ovarian response included four independent predictors: higher anti-Müllerian hormone (AMH) and antral follicle count (AFC) increased the risk, and higher follicle-stimulating hormone (FSH) levels and advancing age decreased the risk of high ovarian response. The regression model for low ovarian response also included four independent predictors: advancing age increased the risk, and higher AMH, higher AFC and longer menstrual cycle length decreased the risk of low ovarian response. Conclusions AMH, AFC and age predicted both high and low ovarian responses, FSH predicted high ovarian response, and menstrual cycle length predicted low ovarian response in a corifollitropin alfa/GnRH antagonist protocol

LOCAL GOVERNMENT LAND USE RESTRICTIONS AND SELECTED FIRST AMENDMENT ISSUES

A local government\u27s power to enact zoning regulations falls within the general power to provide for the health, safety, and welfare of its citizenry. This thesis addresses a few selected First Amendment issues as they apply to zoning and land use restrictions in Georgia. Free speech review of zoning ordinances applies to zoning for adult sex businesses, such as adult book stores and cinemas. The First Amendment balancing test that is applicable to adult entertainment ordinances is discussed in Chapter One. The free speech impact of restrictions on signs and billboards is discussed in Chapter Two. Finally, in Chapter Three, zoning and the free exercise clause of the First Amendment is discussed as it applies to the regulation of religious uses of land. The United States Congress enacted legislation to protect religious institutions from government regulation. However, the legislation was unconstitutional. Georgia courts do not recognize First Amendment protection for religious uses in the face of zoning regulations. A traditional zoning analysis is applied with regulations being invalidated only if they are unreasonable or arbitrary

Teacher as Researcher: A Two-Tiered Model

This thesis focuses on an investigation I undertook to enhance my effectiveness to teach mathematics, a subject to which I was assigned, but for which I had not been formally trained. It describes my attempt to construct knowledge through the clinical interview method as to how middle school students construct knowledge about integers and think about the knowledge they are constructing. On one level, I was attempting to learn how students come to understand the concept of integers; on a level, I was creating an understanding of how a teacher can construct knowledge about the construction of knowledge. This two-tiered model cast me in the roles of teacher, learner and researcher; and my students in the roles of learner and teacher. Six sixth-grade students, interviewed in groups of two each, for four or five sessions, used a model where yellow chips represent positive integers, and blue chips represent negative integers. The investigation was concerned with how children construct knowledge about adding and subtracting integers, what they grasp easily or find difficult, what prior knowledge or misconceptions they bring, what connections they make to real-world applications, how they think about their thinking, how they create problems to solve, and how well they teach fourth graders. The study allowed me to concentrate on aspects of teaching mathematics emphasized by the Standards (1989) of the National Council of Teachers of Mathematics: using manipulative models, problem solving, communicating, connecting and reasoning. Three non-traditional techniques were used for evaluating children\u27s understanding: reverse processing, metacognition, and the child as teacher. As background, this thesis reviews relevant literature on Constructivisn, meaning of knowledge, critical and creative thinking, the teacher\u27s role, clinical interviewing, and representational models. Analyses of videotaped teacher/student scripts and other components of the interviewing process provided glimpses into the minds of children who learn in different ways (including interesting misconceptions held). Implications of this two-tiered model reinforce my belief that knowledge is not something passive to be given, but active to be created and re-created by both teacher and student on a day-to-day basis in the classroom

Patients\u27 perceptions of spiritual needs and the role of nurses to resolve spiritual needs

This study replicated Finney\u27s (1989) study which examined acutely ill hospitalized patients\u27 perceptions of spiritual needs and the nurse\u27s role in assisting them to resolve those needs. The Spiritual Needs of Patients questionnaire (Martin, Burrows, & Pomilio, 1976) was used to assess patients (n = 73) in a southwestern regional hospital. Reliability was reported as Cronbach\u27s alpha at 0.68. Findings supported Finney\u27s study as well as the original study (Martin et al., 1976) and Hoskins (1986). Patients\u27 responses supported the statement that a person who is ill thinks more about his/her relationship to God. The most important spiritual need identified was knowledge of God\u27s presence, with sacraments and communion being identified as the least important. Respondents supported spiritual nursing interventions including nurses asking patients if they wish to see a clergy person, giving spiritual care by being concerned, cheerful, and kind, sitting down and listening, and encouraging a patient to talk about anything that is bothering him/her. A Mann-Whitney U test was performed to determine differences between demographic groups in regard to spiritual care. Only ages 50-69 compared with 70-91 showed any significant difference with a z score of {dollar}-{dollar}2.021, p = 0.04