1,203 research outputs found
Are there multiple kinds of episodic memory? An fMRI investigation comparing autobiographical and recognition memory tasks
What brain regions underlie retrieval from episodic memory? The bulk of research addressing this question with fMRI has relied upon recognition memory for materials encoded within the laboratory. Another, less dominant tradition has used autobiographical methods, whereby people recall events from their lifetime, often after being cued with words or pictures. The current study addresses how the neural substrates of successful memory retrieval differed as a function of the targeted memory when the experimental parameters were held constant in the two conditions (except for instructions). Human participants studied a set of scenes and then took two types of memory test while undergoing fMRI scanning. In one condition (the picture memory test), participants reported for each scene (32 studied, 64 nonstudied) whether it was recollected from the prior study episode. In a second condition (the life memory test), participants reported for each scene (32 studied, 64 nonstudied) whether it reminded them of a specific event from their preexperimental lifetime. An examination of successful retrieval (yes responses) for recently studied scenes for the two test types revealed pronounced differences; that is, autobiographical retrieval instantiated with the life memory test preferentially activated the default mode network, whereas hits in the picture memory test preferentially engaged the parietal memory network as well as portions of the frontoparietal control network. When experimental cueing parameters are held constant, the neural underpinnings of successful memory retrieval differ when remembering life events and recently learned events
GBRDs over groups of orders ≤100 or of order pq with p, q primes
AbstractThere are well-known necessary conditions for the existence of a generalized Bhaskar Rao design over a group G, with block size k=3. It has been conjectured that these necessary conditions are indeed sufficient. We prove that they are sufficient for groups G of order pq where p,q are primes and for groups of all orders ≤100 except possibly 32, 36, 48, 54, 60, 64, 72, 96
Patterned Irradiation of YBa_2Cu_3O_(7-x) Thin Films
We present a new experiment on YBa_2Cu_3O_{7-x} (YBCO) thin films using
spatially resolved heavy ion irradiation. Structures consisting of a periodic
array of strong and weak pinning channels were created with the help of metal
masks. The channels formed an angle of +/-45 Deg with respect to the symmetry
axis of the photolithographically patterned structures. Investigations of the
anisotropic transport properties of these structures were performed. We found
striking resemblance to guided vortex motion as it was observed in YBCO single
crystals containing an array of unidirected twin boundaries. The use of two
additional test bridges allowed to determine in parallel the resistivities of
the irradiated and unirradiated parts as well as the respective current-voltage
characteristics. These measurements provided the input parameters for a
numerical simulation of the potential distribution of the Hall patterning. In
contrast to the unidirected twin boundaries in our experiment both strong and
weak pinning regions are spatially extended. The interfaces between
unirradiated and irradiated regions therefore form a Bose-glass contact. The
experimentally observed magnetic field dependence of the transverse voltage
vanishes faster than expected from the numerical simulation and we interpret
this as a hydrodynamical interaction between a Bose-glass phase and a vortex
liquid.Comment: 7 pages, 8 Eps figures included. Submitted to PR
Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1-Dependent Uncoupling of Endothelial Nitric Oxide Synthase
Endothelial dysfunction is a hallmark of many chronic diseases, including diabetes and long-term hypertension. We show that acute traumatic brain injury (TBI) leads to endothelial dysfunction in rat mesenteric arteries. Endothelial-dependent dilation was greatly diminished 24 h after TBI because of impaired nitric oxide (NO) production. The activity of arginase, which competes with endothelial NO synthase (eNOS) for the common substrate l-arginine, were also significantly increased in arteries, suggesting that arginase-mediated depletion of l-arginine underlies diminished NO production. Consistent with this, substrate restoration by exogenous application of l-arginine or inhibition of arginase recovered endothelial function. Moreover, evidence for increased reactive oxygen species production, a consequence of l-arginine starvation-dependent eNOS uncoupling, was detected in endothelium and plasma. Collectively, our findings demonstrate endothelial dysfunction in a remote vascular bed after TBI, manifesting as impaired endothelial-dependent vasodilation, with increased arginase activity, decreased generation of NO, and increased O(2)(-) production. We conclude that blood vessels have a “molecular memory” of neurotrauma, 24 h after injury, because of functional changes in vascular endothelial cells; these effects are pertinent to understanding the systemic inflammatory response that occurs after TBI even in the absence of polytrauma
Dynamic Inositol Trisphosphate-mediated Calcium Signals within Astrocytic Endfeet Underlie Vasodilation of Cerebral Arterioles
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