Aerodynamic Optimization of a Golf Driver Using Computational Fluid Dynamics

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143102/1/6.2017-0724.pd

Efeito da concentração de compostos do pré-tratamento de biomassa florestal no crescimento de Saccharomyces cerevisiae industrial.

Editores técnicos: Marcílio José Thomazini, Elenice Fritzsons, Patrícia Raquel Silva, Guilherme Schnell e Schuhli, Denise Jeton Cardoso, Luziane Franciscon. EVINCI. Resumos

Comparative Genetic Screens in Human Cells Reveal New Regulatory Mechanisms in WNT Signaling

The comprehensive understanding of cellular signaling pathways remains a challenge due to multiple layers of regulation that may become evident only when the pathway is probed at different levels or critical nodes are eliminated. To discover regulatory mechanisms in canonical WNT signaling, we conducted a systematic forward genetic analysis through reporter-based screens in haploid human cells. Comparison of screens for negative, attenuating and positive regulators of WNT signaling, mediators of R-spondin-dependent signaling and suppressors of constitutive signaling induced by loss of the tumor suppressor adenomatous polyposis coli or casein kinase 1α uncovered new regulatory features at most levels of the pathway. These include a requirement for the transcription factor AP-4, a role for the DAX domain of AXIN2 in controlling β-catenin transcriptional activity, a contribution of glycophosphatidylinositol anchor biosynthesis and glypicans to R-spondin-potentiated WNT signaling, and two different mechanisms that regulate signaling when distinct components of the β-catenin destruction complex are lost. The conceptual and methodological framework we describe should enable the comprehensive understanding of other signaling systems

COMPETITION AMONG HOSPITALS AND ITS MEASUREMENT: THEORY AND A CASE STUDY

Our paper provides several insights on the characteristics of the concept of “Poles d’Excellence Rurale” (PER) through bilateral comparisons with that of Competitive Pole (CP) and cluster. The concept of PER is a French government’ initiative designed for the development of rural areas similar to that of the Competitive Pole. We emphasize important particularities of these concepts by analyzing some of their similarities and major differences.Pole d’Excellence Rurale, Competitive Pole, cluster, rural development

Influência de compostos do pré-tratamento de biomassa florestal no crescimento de Saccharomyces cerevisiae JP1.

Resumo. Disponível online. MIPE

Vestibular dysfunction in the adult CBA/CaJ mouse after lead and cadmium treatment

Objectives: The vestibular system allows the perception of position and motion and its dysfunction presents as motion impairment, vertigo and balance abnormalities, leading to debilitating psychological discomfort and difficulty performing daily tasks. Although declines and deficits in vestibular function have been noted in rats exposed to lead (Pb) and in humans exposed to Pb and cadmium (Cd), no studies have directly examined the pathological and pathophysiological effects upon the vestibular apparatus of the inner ear. Methods: Eighteen young adult mice were exposed through their drinking water (3 mM Pb, 300 µM Cd, or a control treatment) for 10 weeks. Before and after treatment, they underwent a vestibular assessment, consisting of a rotarod performance test and a novel head stability test to measure the vestibulocolic reflex. At the conclusion of the study, the utricles were analyzed immunohistologically for condition of hair cells and nerve fibers. Results: Increased levels of Pb exposure correlated with decreased head stability in space; no significant decline in performance on rotarod test was found. No damage to the hair cells or the nerve fibers of the utricle was observed in histology. Conclusions: The young adult CBA/CaJ mouse is able to tolerate occupationally‐relevant Pb and Cd exposure well, but the correlation between Pb exposure and reduced head stability suggests that Pb exposure causes a decline in vestibular function. © 2016 Wiley Periodicals, Inc. Environ Toxicol, 2016. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 869–876, 2017.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136249/1/tox22286_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136249/2/tox22286.pd

Occupational noise exposure and risk of hypertension in an industrial workforce

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140051/1/ajim22775_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/140051/2/ajim22775.pd