The Radio Spectrum of TVLM513-46546: Constraints on the Coronal Properties of a Late M Dwarf

We explore the radio emission from the M9 dwarf, TVLM513-46546, at multiple radio frequencies, determining the flux spectrum of persistent radio emission, as well as constraining the levels of circular polarization. Detections at both 3.6 and 6 cm provide spectral index measurement $\alpha$ (where S$_{\nu} \propto \nu^{\alpha}$) of $-0.4\pm0.1$. A detection at 20 cm suggests that the spectral peak is between 1.4 and 5 GHz. The most stringent upper limits on circular polarization are at 3.6 and 6 cm, with $V/I <$15%. These characteristics agree well with those of typical parameters for early to mid M dwarfs, confirming that magnetic activity is present at levels comparable with those extrapolated from earlier M dwarfs. We apply analytic models to investigate the coronal properties under simple assumptions of dipole magnetic field geometry and radially varying nonthermal electron density distributions. Requiring the spectrum to be optically thin at frequencies higher than 5 GHz and reproducing the observed 3.6 cm fluxes constrains the magnetic field at the base to be less than about 500 G. There is no statistically significant periodicity in the 3.6 cm light curve, but it is consistent with low-level variability.Comment: 11 pages, 2 figures Accepted for publication in the Astrophysical Journa

Probing the Intergalactic Medium with Fast Radio Bursts

The recently discovered fast radio bursts (FRBs), presumably of extra-galactic origin, have the potential to become a powerful probe of the intergalactic medium (IGM). We point out a few such potential applications. We provide expressions for the dispersion measure and rotation measure as a function of redshift, and we discuss the sensitivity of these measures to the HeII reionization and the IGM magnetic field. Finally we calculate the microlensing effect from an isolate, extragalctic stellar-mass compact object on the FRB spectrum. The time delays between the two lensing images will induce constructive and destructive interference, leaving a specific imprint on the spectra of FRBs. With a high all-sky rate, a large statistical sample of FRBs is expected to make these applications feasible.Comment: 4 pages, 1 figure; Typos for the variable x in Eq.6 corrected; Published in ApJ; Originally the Appendix E of arXiv:1402.4766; Separated from the main paper upon the referee's reques

Why are acute admissions to hospital of children under 5 years of age increasing in the UK?

Children’s use of hospital services in the UK has been increasing rapidly since the late 1990s.1–6 Findings from the latest QualityWatch report show significant increases in emergency hospital admissions for infants (23%) and young children aged 1–4 years (11%) between 2006/2007 and 2015/2016 (data have been adjusted for population increases in each childhood age group), while children over the age of 15 years showed a decrease in emergency admissions

Quantum chaos and critical behavior on a chip

The Dicke model describes N qubits (or two-level atoms) homogenously coupled to a bosonic mode. Here we examine an open-system realization of the Dicke model, which contains critical and chaotic behaviour. In particular, we extend this model to include an additional open transport qubit (TQ) (coupled to the bosonic mode) for passive and active measurements. We illustrate how the scaling (in the number of qubits N) of the superradiant phase transition can be observed in both current and current-noise measurements through the transport qubit. Using a master equation, we also investigate how the phase transition is affected by the back-action from the transport qubit and losses in the cavity. In addition, we show that the non-integrable quantum chaotic character of the Dicke model is retained in an open-system environment. We propose how all of these effects could been seen in a circuit QED system formed from an array of superconducting qubits, or an atom chip, coupled to a quantized resonant cavity (e.g., a microwave transmission line).Comment: 7 page

A comparative study of the schizontocidal efficacy and safety of artemether versus chloroquine in uncomplicated malaria

A comparative study of medications being used for malaria treatment in Zimbabwe

Characteristics of the velocity profile at tidal-stream energy sites

Realistic oceanographic conditions are essential to consider in the design of resilient tidal-stream energy devices that can make meaningful contributions to global emissions targets. Depth-averaged or simplified velocity profiles are often used in studies of device performance, or device interaction with the environment. We improve representation of flow at tidal-stream energy regions by characterising the velocity profile. At two potential tidal-stream energy sites, the 1/7th power-law with a bed-roughness coefficient of 0.4 accurately described the observed velocity profile on average (\u3e1 month ADCP deployments). Temporal variability in the power-law fit was found at both sites, and best characterised with Generalised Extreme Value distribution; with correlation of variability to tidal condition, wind speed and wave conditions found. The mean velocity profile was accurately simulated using a 3D hydrodynamic model (ROMS) of the Irish Sea (UK) but with temporal variability in accuracy of power-law fits. For all potential tidal sites, the spatial-mean velocity profile was also found to be similar (characterised with ∼1/7th power-law and 0.4 bed-roughness value). Therefore realistic flow conditions can be characterised for tidal-energy research, but dynamically coupled wind-wave-tide models, or long-term observations, are needed to fully characterise velocity profile temporal variability

Helping parents know when to seek help for an acutely ill child: Evidence based co-development of a mobile phone app using complex intervention methodology.

BACKGROUND: Acute illness accounts for the majority of episodes of illness in children under five years of age and is the age group with the highest consultation rate in general practice in the UK. The number of children presenting to emergency care is also steadily increasing, having risen beyond pre-pandemic numbers. Such high, and increasing, rates of consultation have prompted concerns about parents' level of knowledge and confidence in caring for their children when they are ill, and particularly when and how to seek help appropriately. AIM: The ASK SNIFF collaboration research programme identified parents' need for accurate and accessible information to help them know when to seek help for a sick child in 2010. This paper presents the resulting programme of research which aimed to co-develop an evidence-based safety netting intervention (mobile app) to help parents know when to seek help for an acutely ill child under the age of five years in the UK. METHODS: Our programme used a collaborative six step process with 147 parent and 324 health professional participants over a period of six years including: scoping existing interventions, systematic review, qualitative research, video capture, content identification and development, consensus methodology, parent and expert clinical review. RESULTS: Our programme has produced evidence-based content for an app supported by video clips. Our collaborative approach has supported every stage of our work, ensuring that the end result reflects the experiences, perspectives and expressed needs of parents and the clinicians they consult. CONCLUSION: We have not found any other resource which has used this type of approach, which may explain why there is no published evaluation data demonstrating the impact of existing UK resources. Future mobile apps should be designed and developed with the service users for whom they are intended

Precision Pointing of IBEX-Lo Observations

Post-launch boresight of the IBEX-Lo instrument onboard the Interstellar Boundary Explorer (IBEX) is determined based on IBEX-Lo Star Sensor observations. Accurate information on the boresight of the neutral gas camera is essential for precise determination of interstellar gas flow parameters. Utilizing spin-phase information from the spacecraft attitude control system (ACS), positions of stars observed by the Star Sensor during two years of IBEX measurements were analyzed and compared with positions obtained from a star catalog. No statistically significant differences were observed beyond those expected from the pre-launch uncertainty in the Star Sensor mounting. Based on the star observations and their positions in the spacecraft reference system, pointing of the IBEX satellite spin axis was determined and compared with the pointing obtained from the ACS. Again, no statistically significant deviations were observed. We conclude that no systematic correction for boresight geometry is needed in the analysis of IBEX-Lo observations to determine neutral interstellar gas flow properties. A stack-up of uncertainties in attitude knowledge shows that the instantaneous IBEX-Lo pointing is determined to within \sim 0.1\degr in both spin angle and elevation using either the Star Sensor or the ACS. Further, the Star Sensor can be used to independently determine the spacecraft spin axis. Thus, Star Sensor data can be used reliably to correct the spin phase when the Star Tracker (used by the ACS) is disabled by bright objects in its field-of-view. The Star Sensor can also determine the spin axis during most orbits and thus provides redundancy for the Star Tracker.Comment: 22 pages, 18 figure

Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation.

Epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) where aberrant signaling downstream of this receptor contributes to tumor growth. EGFR variant III (EGFRvIII) is the most commonly altered form of EGFR and contains a truncated ligand-binding domain. We previously reported that EGFRvIII is expressed in up to 40% of HNSCC tumors where it is associated with increased proliferation, tumor growth and chemoresistance to antitumor drugs including the EGFR-targeting monoclonal antibody cetuximab. Cetuximab was FDA-approved in 2006 for HNSCC but has not been shown to prevent invasion or metastasis. This study was undertaken to evaluate the mechanisms of EGFRvIII-mediated cell motility and invasion in HNSCC. We found that EGFRvIII induced HNSCC cell migration and invasion in conjunction with increased signal transducer and activator of transcription 3 (STAT3) activation, which was not abrogated by cetuximab treatment. Further investigation showed that EGF-induced expression of the STAT3 target gene HIF1-α, was abolished by cetuximab in HNSCC cells expressing wild-type EGFR under hypoxic conditions, but not in EGFRvIII-expressing HNSCC cells. These results suggest that EGFRvIII mediates HNSCC cell migration and invasion by increased STAT3 activation and induction of HIF1-α, which contribute to cetuximab resistance in EGFRvIII-expressing HNSCC tumors