The multinational corporation: a study in the political economy of power Neil Gordon McDonald Renwick

This study focuses on the question of how far multinational corporations lie beyond the regulatory control of nation-states. In what sense are these corporations autonomous organisations whose rules Ana practice exist independent of State control? This is a political rather than economic question, for concepts such as power, control or independence are fundamentally political in nature,. The thesis analyses four leading interpretations or the multinationals and their relations with States, the actual characteristics of both 'actors' and the role of oil multinationals in the international oil industry in relation to 'host' and 'home' governments. Much of the debate over multinationals centres upon their unique character. Organised on the basis of productive capital in a number of countries, that is, subsidiaries linked to centralised managerial; technical and financial resources, it is argued that these companies exercise global flexibility with which the States tied to their borders- cannot compete. 'Global Reach' is therefore claimed to allow multinationals to ignore national regulations and interests. This analysis, however, suggests that the multinational-State relationship takes place within the framework of national regulations and international supervisory bodies that effectively form the 'rules' for the multinationals and the boundaries for bargaining. The multinational forms an important and integral part of the prevailing system that is largely reflective of State-interests, rather than a major challenge to the authority of the States

MicroRNAs MiR-17, MiR-20a, and MiR-106b Act in Concert to Modulate E2F Activity on Cell Cycle Arrest during Neuronal Lineage Differentiation of USSC

MicroRNAs are short (∼22 nt) non-coding regulatory RNAs that control gene expression at the post-transcriptional level. Here the functional impact of microRNAs on cell cycle arrest during neuronal lineage differentiation of unrestricted somatic stem cells from human cord blood (USSC) was analyzed./M transition. Most strikingly, miR-17, -20a, and -106b were found to promote cell proliferation by increasing the intracellular activity of E2F transcription factors, despite the fact that miR-17, -20a, and -106b directly target the transcripts that encode for this protein family./S transition

Two Distinct Gamma-2 Herpesviruses in African Green Monkeys: a Second Gamma-2 Herpesvirus Lineage among Old World Primates?

Primate gamma-2 herpesviruses (rhadinoviruses) have so far been found in humans (Kaposi's sarcoma-associated herpesvirus [KSHV], also called human herpesvirus 8), macaques (Macaca spp.) (rhesus rhadinovirus [RRV] and retroperitoneal fibromatosis herpesvirus [RFHV]), squirrel monkeys (Saimiri sciureus) (herpesvirus saimiri), and spider monkeys (Ateles spp.) (herpesvirus ateles). Using serological screening and degenerate consensus primer PCR for the viral DNA polymerase gene, we have detected sequences from two distinct gamma-2 herpesviruses, termed Chlorocebus rhadinovirus 1 (ChRV1) and ChRV2, in African green monkeys. ChRV1 is more closely related to KSHV and RFHV, whereas ChRV2 is closest to RRV. Our findings suggest the existence of two distinct rhadinovirus lineages, represented by the KSHV/RFHV/ChRV1 group and the RRV/ChRV2 group, respectively, in at least two Old World monkey species. Antibodies to members of the RRV/ChRV2 lineage may cross-react in an immunofluorescence assay for early and late KSHV antigens

Classifying Lung Neuroendocrine Neoplasms through MicroRNA Sequence Data Mining

Lung neuroendocrine neoplasms (NENs) can be challenging to classify due to subtle histologic differences between pathological types. MicroRNAs (miRNAs) are small RNA molecules that are valuable markers in many neoplastic diseases. To evaluate miRNAs as classificatory markers for lung NENs, we generated comprehensive miRNA expression profiles from 14 typical carcinoid (TC), 15 atypical carcinoid (AC), 11 small cell lung carcinoma (SCLC), and 15 large cell neuroendocrine carcinoma (LCNEC) samples, through barcoded small RNA sequencing. Following sequence annotation and data preprocessing, we randomly assigned these profiles to discovery and validation sets. Through high expression analyses, we found that miR-21 and -375 are abundant in all lung NENs, and that miR-21/miR-375 expression ratios are significantly lower in carcinoids (TC and AC) than in neuroendocrine carcinomas (NECs; SCLC and LCNEC). Subsequently, we ranked and selected miRNAs for use in miRNA-based classification, to discriminate carcinoids from NECs. Using miR-18a and -155 expression, our classifier discriminated these groups in discovery and validation sets, with 93% and 100% accuracy. We also identified miR-17, -103, and -127, and miR-301a, -106b, and -25, as candidate markers for discriminating TC from AC, and SCLC from LCNEC, respectively. However, these promising findings require external validation due to sample size

Risk factors for human herpesvirus 8 infection in a cohort of drug users in The Netherlands, 1985-1996

To elucidate the mode of human herpesvirus 8 (HHV-8) transmission in a population of Amsterdam drug users, HHV-8 seroprevalence and seroincidence were determined in 1179 drug users in the Amsterdam Cohort Studies (1985-1996). Risk factors for HHV-8 infection were examined. Serum samples were screened with an enzyme immunoassay by using HHV-8 lytic capsid (open-reading frame [ORF] 65) and latent nuclear (ORF73) antigens; positive results were confirmed by Western blot and immunofluorescence assay. Seroprevalence (men, 3.4%; women, 1.4%) and seroincidence (men, 0.08; women, 0.05/100 person-years) were low in this study. Infections with human immunodeficiency virus (HIV) type 1, hepatitis B virus (HBV), and hepatitis C virus (HCV), but not HHV-8, were associated with injection drug use (IDU). Independent risk factors for HHV-8 seropositivity were homosexual contacts and Mediterranean nationality for men and sexual contact with bisexual men, absence of a steady partner, and unprotected commercial sex for women. Unlike HIV-1, HBV, or HCV infection, HHV-8 infection is uncommon in Amsterdam drug users, as is HHV-8 transmission through ID

Human herpesvirus 8 infections in the Amsterdam Cohort Studies (1984–1997): Analysis of seroconversions to ORF65 and ORF73

We have shown previously that human herpesvirus 8 (HHV8) seroconversion for antibodies to the latency-associated nuclear antigen encoded by ORF73 and/or the lytic capsid antigen (vp19) encoded by ORF65 is associated with orogenital contact and is strongly linked to the development of Kaposi's sarcoma among HIV-infected individuals in the Amsterdam Cohort Studies. Here, we investigate the relationship between seroconversion to these antigens and primary HHV8 infection. Between 1984 and 1997, 215 HHV8 seroconversions to ORF73 (106 cases or 49%) and/or to ORF65 (159 cases or 74%) were recorded in the cohort of homosexual men. The HHV8 seroconversion rate among HIV-infected homosexual men (6.2 per 100 person years) was consistently higher than among HIV-uninfected men (2.6 per 100 person years). In HIV-infected but not in uninfected individuals, seroconversion to ORF73/latency-associated nuclear antigen precedes that to ORF65/vp19. Antibody levels to both ORF65- and ORF73-encoded antigens were higher in HIV-infected than in HIV-uninfected men, and among HIV-seropositives, antibody levels to ORF65/vp19 rise even higher with declining CD4 cell counts and peak with Kaposi's sarcoma development, suggesting continuing and increasing viral replication. In 10.3% of HHV8 seroconversions, transient serum viremia could be demonstrated before or at seroconversion. Together with the previously reported link between unprotected orogenital sex and HHV8 seroconversion, our observations suggest that HHV8 seroconversions result from primary infections

Palaeocirculation across New Zealand during the last glacial maximum at similar to 21 ka

What circulation pattern drove Southern Alps glacial advances at similar to 21 ka? Late 20th century glacial advances in New Zealand are commonly attributed to a dual precipitation increase and cooler than normal temperatures associated with enhanced westerly flow that occur under synoptic pressure patterns termed 'zonal' regimes (Kidson, 2000). But was the circulation pattern that supported major Southern Alps glacial advances during the global LGM similar to the modern analog? Here, a Regional Climate Regime Classification (RCRC) time slice was used to infer past circulation for New Zealand during the LGM at similar to 21 ka. Palaeoclimate information that supported the construction of the similar to 21 ka time slice was derived from the NZ-INTIMATE Climate Event Stratigraphy (CES), one new Auckland maar proxy record, and additional low-resolution data sourced from the literature.The terrestrial evidence at similar to 21 ka implicates several possibilities for past circulation, depending on how interpretations for some proxies are made. The interpretation considered most tenable for the LGM, based on the agreement between terrestrial evidence, marine reconstructions and palaeoclimate model results is an 'anticyclonic/zonal' circulation regime characterized by increased influences from blocking 'highs' over the South Island during winter and an increase in zonal and trough synoptic types (with southerly to westerly quarter wind flow) during summer. These seasonal circulation traits would have generated lower mean annual temperatures, cooler than normal summer temperatures, and overall lower mean annual precipitation for New Zealand (particularly in the western South Island) at similar to 21 ka.The anticyclonic/zonal time slice reconstruction presented in this study has different spatial traits than the late 20th Century and the early Little Ice Age signatures, suggesting more than one type of regional circulation pattern can drive Southern Alps glacial activity. This finding lends support to the hypothesis that temperature over precipitation change is more important as the primary modulator of Southern Alps ice advances. The RCRC approach also demonstrates some subtle advantages of integrating multiproxy data within a palaeocirculation context for New Zealand, notably because this reconstruction technique enables direct comparisons to coarsely resolved palaeoclimate model outputs that do not have downscaled information. (C) 2011 Elsevier Ltd. All rights reserved