Ontology based approach for video transmission over the network

With the increase in the bandwidth & the transmission speed over the internet, transmission of multimedia objects like video, audio, images has become an easier work. In this paper we provide an approach that can be useful for transmission of video objects over the internet without much fuzz. The approach provides a ontology based framework that is used to establish an automatic deployment of video transmission system. Further the video is compressed using the structural flow mechanism that uses the wavelet principle for compression of video frames. Finally the video transmission algorithm known as RRDBFSF algorithm is provided that makes use of the concept of restrictive flooding to avoid redundancy thereby increasing the efficiency.Comment: 7 pages, 2 figures, 4 table

Vibrant Yet Under-Resourced: The State of Lesbian, Bisexual, and Queer Movements

Lesbian, bisexual, and queer (LBQ) movements are doing essential work around the world, and this global moment reflects their leadership. As Black Lives Matter movements push to dismantle racism and white supremacy, the grassroots abolition-centered work of many Black LBQ organizers has been a galvanizing force. Throughout the COVID-19 crisis, LBQ groups have provided critical mutual aid, collective care support, and creative movement-building strategies to meet the moment.Astraea Lesbian Foundation for Justice and Mama Cash compiled data from 378 activists in 97 countries and 67 donors across philanthropy to create Vibrant Yet Under-Resourced, a report documenting LBQ activists' priorities and the current lack of resourcing for their work, and makes a powerful case for why increased and more effective funding is crucially needed

Geometrical Analysis of Occlusal Plane using Frankfort Horizontal Plane: A Cephalometric Comparative Study.

For many years prosthodontists have been trying to find out the ideal location of Occlusal plane during complete denture fabrication. Though there is abundant literature which supports various methods to establish an artificial occlusal plane in edentulous patients, there is a lack of literature correlating which method establishes an occlusal plane that lies closest to the one occurring naturally. Hence this study was done to evaluate and establish a reliable method of occlusal plane determination in edentulous individuals and was carried out in 30 dentulous and 30 edentulous patients using lateral cephalograms. This study was performed in the Department of Prosthodontics, Tamilnadu Government Dental College and Hospital, Chennai. In this study conducted, 1. The angulation between the occlusal plane established in the edentulous patients using Hamular notch - Incisive Papilla plane and Frankfort Horizontal plane had closely resembled the angulation between the natural occlusal plane and Frankfort Horizontal plane in dentulous subjects. 2. The angulation between the occlusal plane established in the edentulous patients using the junction of middle and upper third of the retromolar pad as the reference and Frankfort Horizontal plane had also closely resembled the angulation between the natural occlusal plane and Frankfort Horizontal plane of the dentulous subjects next to the similarity obtained from the HIP as reference. 3. The angulation between the occlusal plane established in the edentulous patients using the Camper’s plane as the reference and Frankfort Horizontal plane showed a marked degree of variation from the corresponding angulation seen in the dentulous subjects and the two previous groups. 4. The angulation of occlusal plane and Frankfort Horizontal plane showed the minimum variation in dentulous subjects. Hence from the present study, it has been concluded that, Among the three methods used to establish an artificial occlusal plane, HIP plane is found to be more reliable reference plane in complete denture construction. • The occlusal plane established using the junction of the middle and upper third of the retromolar pad and the corner of the mouth as the reference can also be considered as a reliable guide to establish an artificial occlusal plane. • Camper’s plane shows a marked degree of variability as compared to the other two groups and it is not considered as a reliable reference plane to be used for establishing the occlusal plane during complete denture fabrication. • 9.3 is the average value of the angle between the occlusal plane and Frankfort Horizontal plane in the Indian population. • However, clinical judgement plays a major role in the assessment of occlusal plane in the edentulous patients. So this Geometrical analysis may be taken as a useful adjunct in establishing the occlusal plane

Risk of prostate cancer and its correlation with different biochemical parameters in non diabetic men

Background: It has been hypothesized that men with long term diabetes have a lower risk of prostate cancer then non-diabetic men. Whether diabetes influences level of biomarkers such as prostate specific antigen (PSA), which is involved in the detection of prostate cancer is, unknown. In view of the aforementioned controversial literature, it was decided to evaluate this relation-ship in non-diabetic men. We evaluated the correlation between fasting glucose, prostate specific antigen and different biochemical lipid profile parameters with serum uric acid and serum creatinine in non-diabetic male between age group 40-61 years.Methods: Association between fasting serum glucose , different lipid parameters, serum uric acid, serum creatinine and prostate specific antigen in 83 non-diabetic males aged 40 to 61years were studied retrospectively. Glucose and lipid parameters and serum creatinine, serum uric acid were measured on fully automated analyser using standard reagent kits. Serum prostate specific antigen was measured by TOSOH-AIA-360, immunoassay method.Results: Correlations between different biochemical parameters were determined. Prostate specific antigen were negatively correlated with HDL (r= -0.22, p= 0.03) in age group 40-61 years. At the same fasting blood sugar were correlated positively(r= 0.34, p= 0.02 ) with prostate specific antigen in age group 51-60 years , but not in age group 40-50 years.Conclusion: We concluded that serum HDL (high density lipoprotein) was negatively associated and FBS (fasting blood sugar) was positively associated with risk of prostate cancer. We also suggest that in men of this age group a low HDL level should not be ignored while assessing prostate cancer risk especially if accompanied with an elevated FBS level even in the upper normal range.

Ultrafast Dynamics of Gold Nanorods: Tuning between Photo-Bleaching and Photo-Induced Absorption

We report ultrafast electron dynamics in gold nanorods investigated using 80 fs laser pulses centered at 1.57 eV. Five types of nanorod colloidal suspensions in water having their longitudinal surface plasmon peak (ELSP) on either side of the laser photon energy (EL) have been studied. For ELSP>EL, photo-induced absorption with single decay time constant is observed. On the other hand, for ELSP<EL, photo-bleaching is observed having biexponential decay dynamics; the faster one between 1-3 ps and slower one between 7ps to 22ps both of them increasing almost linearly with the difference |EL-ELSP|. These time constants increase linearly with the pump intensity. Simulations have been carried out to understand the interplay between photo-bleaching and photoinduced absorption.Comment: 4 pages, 4 figures, To appear in International Journal of Nanoscience, 201

High AU content: a signature of upregulated miRNA in cardiac diseases

MicroRNAs have been implicated for the regulation of gene expression. These miRNA are a class of single stranded non coding RNAs, formed from endogenous transcripts and measure typically about 19-25 nucleotides in length. They are important regulators of the various biological and metabolic functions taking place in humans. Many miRNAs show tissue specific expression. Human heart is a complex organ which during various diseased and developed conditions shows differential expression of miRNA. Here, we overview the recent findings on miRNA in cardiac diseases and report the presence of high AU content in differentially expressed miRNA in developed and diseased condition of heart as compared to all the miRNA present in the human. A total of 905 human miRNA sequences taken from miRBase were computationally analyzed. Trend analysis was performed to study the influence of positional frequency of the nucleotides. This study will help us in understanding the significance of AU rich elements in miRNA during the development of cardiac diseases.Peer reviewe

Time Series Analysis of SARS-CoV-2 Genomes and Correlations among Highly Prevalent Mutations

The efforts of the scientific community to tame the recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seem to have been diluted by the emergence of new viral strains. Therefore, it is imperative to understand the effect of mutations on viral evolution. We performed a time series analysis on 59,541 SARS-CoV-2 genomic sequences from around the world to gain insights into the kinetics of the mutations arising in the viral genomes. These 59,541 genomes were grouped according to month (January 2020 to March 2021) based on the collection date. Meta-analysis of these data led us to identify significant mutations in viral genomes. Pearson correlation of these mutations led us to the identification of 16 comutations. Among these comutations, some of the individual mutations have been shown to contribute to viral replication and fitness, suggesting a possible role of other unexplored mutations in viral evolution. We observed that the mutations 241C.T in the 59 untranslated region (UTR), 3037C.T in nsp3, 14408C.T in the RNA-dependent RNA polymerase (RdRp), and 23403A.G in spike are correlated with each other and were grouped in a single cluster by hierarchical clustering. These mutations have replaced the wild-type nucleotides in SARS-CoV-2 sequences. Additionally, we employed a suite of computational tools to investigate the effects of T85I (1059C.T), P323L (14408C.T), and Q57H (25563G.T) mutations in nsp2, RdRp, and the ORF3a protein of SARS-CoV-2, respectively. We observed that the mutations T85I and Q57H tend to be deleterious and destabilize the respective wild-type protein, whereas P323L in RdRp tends to be neutral and has a stabilizing effect. IMPORTANCE We performed a meta-analysis on SARS-CoV-2 genomes categorized by collection month and identified several significant mutations. Pearson correlation analysis of these significant mutations identified 16 comutations having absolute correlation coefficients of .0.4 and a frequency of .30% in the genomes used in this study. The correlation results were further validated by another statistical tool called hierarchical clustering, where mutations were grouped in clusters on the basis of their similarity. We identified several positive and negative correlations among comutations in SARS-CoV-2 isolates from around the world which might contribute to viral pathogenesis. The negative correlations among some of the mutations in SARS-CoV-2 identified in this study warrant further investigations. Further analysis of mutations such as T85I in nsp2 and Q57H in ORF3a protein revealed that these mutations tend to destabilize the protein relative to the wild type, whereas P323L in RdRp is neutral and has a stabilizing effect. Thus, we have identified several comutations which can be further characterized to gain insights into SARS-CoV-2 evolution.</p

Whole Exome Sequencing Leading to the Diagnosis of Dysferlinopathy with a Novel Missense Mutation (c.959G>C)

Dysferlinopathy is an uncommon, progressive muscular dystrophy that has a wide phenotypic variability and primarily supportive management (Nguyen et al., 2007; Narayanaswami et al., 2014). Amyloid myopathy is a distinct, rare disorder that can present similarly to inflammatory myopathies and requires a high clinical suspicion for early intervention to prolong survival. Amyloid myopathy is typically associated with other systemic manifestations of amyloidosis, but rare cases of isolated amyloid myopathy have been described (Mandl et al., 2000; Hull et al., 2001). Positive Congo red stains on tissue biopsy remain the gold standard for diagnosis (Spuler et al., 1998; Karacostas et al., 2005). A high clinical suspicion and meticulous diagnostic workup that includes novel techniques are necessary for identifying these rare disorders. We report a middle-aged man with progressive leg muscle weakness who was initially treated as having amyloid myopathy but was later diagnosed as having dysferlinopathy by Whole Exome Sequencing (WES) analysis. We also report a novel missense mutation (c.959G>C) to help correlate in any patient with presumed dysferlinopathy and to add to the already known genotype of this disorder