Chediak higashi syndrome: A case report of rare anomaly

Chediak Higashi syndrome (CHS) is a rare autosomal recessive immunodeficiency disorder that arises due to the mutation of a trafficking protein which leads to a decrease in phagocytosis. This results in frequent pyogenic infections, albinism, and peripheral neuropathy. Infections in these patients tend to be very serious and life-threatening. CHS is caused by mutations in a gene LYST on chromosome 1. Here, we report the case of CHS in a 4-year-old boy who presented to us with recurrent fever, splenomegaly, and hypopigmentation. This case is being presented due to its rarity and presentation of pancytopenia without hemophagocytosis

Estimation of the heat generation in vitrified waste product and shield thickness for the transportation of vitrified waste product using Monte Carlo technique

867-869High Level liquid Waste (HLW) generated during reprocessing of spent fuel contains most of the radioactivity present in entire nuclear fuel cycle resulting in need for its containment, isolation and surveillance for extended periods of time. The major components of HLW are corrosion products, fission products such as 137Cs, 90Sr, 106Ru, 144Ce 125Sb etc, actinides and various chemicals used during reprocessing of HLW. Fresh HLW having an activity concentration of around 100 Ci/l is vitrified into borosilicate glass and contained in canisters which are placed in SS overpacks for better confinement. These overpacks contain about 0.7 million Curies of activity. For transporting the vitrified waste product (VWP), two most important parameters are shield thickness of transportation cask and heat generation in vitrified waste product. This paper describes methodology used in estimation of Pb thickness for transportation cask using the Monte Carlo technique. Using the same technique, heat generation in canister and overpack containing vitrified glass were also estimated

Association of human interleukin-35 level in gingival crevicular fluid and serum in periodontal health, disease, and after nonsurgical therapy: A comparative study

Background: Innovating newer methods to diagnose a multifactorial disease such as periodontitis is always challenging for a clinician. Gingival crevicular fluid (GCF) which is closely associated with the periodontal tissue environment has been used a viable alternative to saliva for the diagnosis of periodontitis. Aim: The aim of the present study was to estimate and compare the interleukin-35 (IL-35) levels in GCF and serum among healthy, gingivitis, and chronic periodontitis (CP) individuals as well as to evaluate the effect of nonsurgical periodontal treatment (NSPT) on IL-35 level among patients with CP. Settings and Design: The study was conducted at the Department of Periodontics, Srirama Chandra Bhanja Dental College and Hospital, Cuttack, Odisha, India. It is a comparative study. Materials and Methods: A total of 60 participants were divided into healthy (Group I; n = 20), gingivitis (Group II; n = 20), and CP (Group IIIA; n = 20). GCF samples collected from each individual at baseline and 6 weeks after NSPT for Group III individuals (Group IIIB; n = 20) were quantified for IL-35 levels using enzyme-linked immunosorbent assay. Statistical Analysis: All analyses were performed using Shapiro–Wilk test, analysis of variance, Tukey's honestly significant difference post hoc test, and multiple regression analysis. Results: The mean IL-35 concentration in GCF was significantly high (P < 0.05) for Group IIIA (70.26 ± 4.0 pg/ml), as compared to Group I (54.81 ± 22.3 pg/ml) and Group IIIB (55.72 ± 10.2 pg/ml). Conclusion: In the present study, GCF and serum IL-35 concentration among CP individuals was highest among all the groups. Individuals receiving NSPT showed a significant reduction in IL-35 levels as compared to CP individuals