73 research outputs found
Author response to Letter to the Editor: âChronological change in alphaâfoetoprotein levels in hepatocellular carcinoma after eradication of hepatitis C virusâ
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156500/2/liv14612.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156500/1/liv14612_am.pd
Moving toward personalizing MELD exceptions in liver transplantation for hepatocellular carcinoma
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/150509/1/ajt15389_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150509/2/ajt15389.pd
Frailty, Psychoactive Medications, and Cognitive Dysfunction Are Associated With Poor PatientâReported Outcomes in Cirrhosis
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/148384/1/hep30336-sup-0001-Supinfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/148384/2/hep30336_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/148384/3/hep30336.pd
Hepatocellular carcinoma surveillance, early detection and survival in a privately insured US cohort
Background/AimsSemiannual hepatocellular carcinoma (HCC) surveillance is recommended in patients with cirrhosis; however, recent studies have raised questions over its utility. We investigated the impact of surveillance on early detection and survival in a nationally representative database.MethodsWe included patients with cirrhosis and HCC from the Optum database (2001â2015) with >6Â months of followâup between cirrhosis and HCC diagnoses. Surveillance adherence was defined as proportion of time covered (PTC), with each 6âmonth period after abdominal imaging defined as âcoveredâ. To determine the association between surveillance and mortality, we compared PTC between fatal and nonâfatal HCC.ResultsOf 1001 patients with cirrhosis and HCC, 256 died with median followâup 30Â months. Median PTC by any imaging was greater in earlyâstage vs lateâstage HCC (43.6% vs 37.4%, PÂ =Â .003) and nonâfatal vs fatal HCC (40.8% vs 34.3%, PÂ =Â .001). In multivariable analyses, each 10% increase in PTC was associated with increased early HCC detection (OR 1.07, 95% CI 1.01â1.12) and decreased mortality (HR 0.95; 95% CI 0.90â1.00). On subgroup analysis, PTC by CT/MRI was associated with early tumour detection and decreased mortality; however, PTC by ultrasound was only associated with early detection but not decreased mortality. These findings were robust across sensitivity analyses.ConclusionsIn a US cohort of privately insured HCC patients, PTC by any imaging modality was associated with increased early detection and decreased mortality. Continued evaluation of HCC surveillance strategies and effectiveness is warranted.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154974/1/liv14379_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154974/2/liv14379.pd
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Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137766/1/hep29248.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137766/2/hep29248_am.pd
Frequency and Outcomes of Abnormal Imaging in Patients With Cirrhosis Enrolled in a Hepatocellular Carcinoma Surveillance Program
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/148235/1/lt25398_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/148235/2/lt25398.pd
The Quality and Outcomes of Care Provided to Patients with Cirrhosis by Advanced Practice Providers
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153696/1/hep30695.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153696/2/hep30695_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153696/3/hep30695-sup-0001-TableS1-S6.pd
Survival and costâeffectiveness of sorafenib therapy in advanced hepatocellular carcinoma: An analysis of the SEERâMedicare database
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135309/1/hep28881-sup-0001-suppinfo.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135309/2/hep28881_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135309/3/hep28881.pd
A risk score to predict the development of hepatic encephalopathy in a populationĂą based cohort of patients with cirrhosis
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146442/1/hep29628_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146442/2/hep29628-sup-0001-suppinfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146442/3/hep29628.pd
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Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138269/1/hep29286.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138269/2/hep29286_am.pd
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