2 research outputs found
Palladium Catalyzed, Multicomponent Synthesis of Fused-Ring Pyrroles from Aryl Iodides, Carbon Monoxide, and Alkyne-Tethered Imines
A palladium-catalyzed
multicomponent route to polycyclic pyrroles
is described. PdÂ(P<sup><i>t</i></sup>Bu<sub>3</sub>)<sub>2</sub> was found to catalyze the coupling of (hetero)Âaryl iodides,
two equivalents of carbon monoxide and alkyne-tethered imines into
1,3-dipoles (Münchnones), which undergo spontaneous, intramolecular
1,3-dipolar cycloaddition to form polycyclic pyrroles. The systematic
variation of the alkyne, tethered-imine, or aryl iodide can allow
the buildup of a range of pyrrole derivatives, where any of the substituents
can be independently varied. In addition, the same palladium catalyst
can be employed in an initial Sonogashira-type coupling with aryl
iodides, which upon the addition of CO can allow the novel tandem
catalytic, five component synthesis of diversely substituted products
Synthesis of pyrimido[4′,5′:5,6][1,4]dithiepino[2,3-b]quinoxalines: Derivatives of a novel seven membered ring system
<p></p> <p>A convenient and efficient procedure for the synthesis of tetracyclic dithiepin derivatives is described through the condensation reaction of 2,4-dichloro-5-(chloromethyl)-6- methylpyrimidine and quinoxaline-2,3-dithiol followed by treatment with secondary amines.</p