15 research outputs found
Channel Length Scaling of MoS2 MOSFETs
In this article, we investigate electrical transport properties in ultrathin
body (UTB) MoS2 two-dimensional (2D) crystals with channel lengths ranging from
2 {\mu}m down to 50 nm. We compare the short channel behavior of sets of
MOSFETs with various channel thickness, and reveal the superior immunity to
short channel effects of MoS2 transistors. We observe no obvious short channel
effects on the device with 100 nm channel length (Lch) fabricated on a 5 nm
thick MoS2 2D crystal even when using 300 nm thick SiO2 as gate dielectric, and
has a current on/off ratio up to ~109. We also observe the on-current
saturation at short channel devices with continuous scaling due to the carrier
velocity saturation. Also, we reveal the performance limit of short channel
MoS2 transistors is dominated by the large contact resistance from the Schottky
barrier between Ni and MoS2 interface, where a fully transparent contact is
needed to achieve a high-performance short channel device.Comment: 22 pages, 6 figures; ACS Nano, ASAP, 201
Treatment Outcomes of Multidrug-Resistant Tuberculosis: A Systematic Review and Meta-Analysis
BACKGROUND:Treatment outcomes for multidrug-resistant Mycobacterium Tuberculosis (MDRTB) are generally poor compared to drug sensitive disease. We sought to estimate treatment outcomes and identify risk factors associated with poor outcomes in patients with MDRTB. METHODOLOGY/PRINCIPAL FINDINGS:We performed a systematic search (to December 2008) to identify trials describing outcomes of patients treated for MDRTB. We pooled appropriate data to estimate WHO-defined outcomes at the end of treatment and follow-up. Where appropriate, pooled covariates were analyzed to identify factors associated with worse outcomes. Among articles identified, 36 met our inclusion criteria, representing 31 treatment programmes from 21 countries. In a pooled analysis, 62% [95% CI 57-67] of patients had successful outcomes, while 13% [9]-[17] defaulted, 11% [9]-[13] died, and 2% [1]-[4] were transferred out. Factors associated with worse outcome included male gender 0.61 (OR for successful outcome) [0.46-0.82], alcohol abuse 0.49 [0.39-0.63], low BMI 0.41[0.23-0.72], smear positivity at diagnosis 0.53 [0.31-0.91], fluoroquinolone resistance 0.45 [0.22-0.91] and the presence of an XDR resistance pattern 0.57 [0.41-0.80]. Factors associated with successful outcome were surgical intervention 1.91 [1.44-2.53], no previous treatment 1.42 [1.05-1.94], and fluoroquinolone use 2.20 [1.19-4.09]. CONCLUSIONS/SIGNIFICANCE:We have identified several factors associated with poor outcomes where interventions may be targeted. In addition, we have identified high rates of default, which likely contributes to the development and spread of MDRTB
Sa1224 Assessing the Performance of Interferon-Gamma Release Assays in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Summary of studies.
<p>RC = Retrospective cohort, PC = prospective cohort, CC = case control, GEN = gender, HIV = HIV positive, DM = diabetes, ALC = alcohol abuse, BMI = low body mass index, SMR = smear positive, CAV = cavitary disease, PRT = prior therapy, 6DR = six drug resistance, FQR = fluoroquinol.</p
Summary of literature search and study selection.
<p>Summary of literature search and study selection.</p