A study to evaluate the role of lipid profile in a patient with cirrhosis and to assess its relationship to the severity of cirrhosis.

Aim: to determine role of lipid profile in a patient with cirrhosis and to assess its relationship to the severity of cirrhosis. Methods The present study was conducted in the Department of Biochemistry, Patna. Medical College and Hospital, Patna, Bihar, India from June 2019 to December 2019. Serum lipid profile was observed in these patients. Results: Mean total cholesterol in cirrhotic study group was 144.47+16.10 and in control group was 160.61+15.65. Mean of total cholesterol was higher in control group than in study group that was statistically significant as p value < .00001. Mean LDL cholesterol in cirrhotic study group was 81.50+14.27 and in control group was 91.96+17.75. Mean of LDL cholesterol was higher in control group than in study group that was statistically significant as p value 0.0012. Conclusions: Serum cholesterol and HDL level decreases with progression of cirrhosis. In future serum lipid profile can be used in classification criteria for assessing severity of liver cirrhosis. Keywords: Chronic liver disease, Lipid profile, Severity of liver cirrhosi

Comparison of Serum Lipoproteins in non-pregnant women of reproductive age group with normal pregnant women without PIH and pregnant women with PIH

Aim: To evaluate the levels of Serum Lipoproteins in Pregnancy Induced Hypertension. Material and Methods: A cross sectional study was conducted in Department of Biochemistry, Patna. Medical College and Hospital, Patna, Bihar, India from July 2019 to January 2020. Total 300 patients include 100 non-pregnant,100 pregnant and 100 PIH cases. Serum cholesterol, lipoproteins and triglyceride levels were evaluated for each of the three groups. Results: In the present study there was no significant difference in serum cholesterol levels between group I (normal, non-pregnant women) and group II (normal pregnant women). However, a significant difference was observed between group I and group III (pregnancy with PIH) the P values being<0.001. The serum cholesterol levels in group III were significantly higher than those in group I. However, there was a significant difference in serum cholesterol levels between group II and group III. The P value being <0.001. Conclusion: Pregnancy induced hypertension is a frequent complication during pregnancy which if advanced may be fatal for both mother and foetus. Endothelial damage might involve elevated serum triglycerides which may have a value that can be used as screening markers in early stages of pregnancy leading to preeclampsia in future. Keywords: Lipid profile, PIH, pregnanc

Study of evaluation of renal function in patients with subclinical and overt hypothyroidism and to correlate these values with the thyroid profile of the patients.

Aim: to analyse the changes in biochemical markers of renal function in patients with subclinical and overt hypothyroidism and to correlate these values with the thyroid profile of the patients Methods: The present analytical cross-sectional was conducted in the Department of Biochemistry, Patna. Medical College and Hospital, Patna, Bihar, India from April  2019 to November  2019. The study includes 100 subclinical hypothyroid patients and 100 overt hypothyroidism (OHT) cases, 200 euthyroid patients (ET). Thyroid function test, serum creatinine and eGFR were measured in all the three groups. Results: There is no significance change in age group among the three groups. We found significant difference in the mean of TSH, free T3. Free T4, serum creatinine and eGFR among the three groups (p < 0.05). Patients suffering from OHT have the highest percentage of increase in serum creatinine in comparison to other  two  groups.  the maximum percentage of patients having decreased GFR(<90  mg/ml/m2)  belongs to the group of patients with OHT and the maximum percentage of patients having normal eGFR belongs to the group of patients with euthyroid condition.The positive significant correlations of Creatinine with TSH (p<0.05) and the negative significant correlations of eGFR with TSH (p<0.05). There is a poor correlation of creatinine and eGFR with thyroid hormones (p>0.05). There is negative significant correlations of creatinine with Free T4 (p< 0.05) and the positive correlations of eGFR with Free T4 (p< 0.05). There is poor correlation of creatinine and eGFR with Free T3 (p>0.05). Conclusions: the renal function and thyroid function are interrelated with each other in SCH cases. SCH patients should be monitored for renal parameters regularly to prevent long term complications. Early diagnosis and early treatment of the disease and can increase the quality of life. Keywords: Overt hypothyroidism, Renal function tests, Subclinical hypothyroidism, Thyroid function test