Additional file 1: Table S1. of Early troponin I in critical illness and its association with hospital mortality: a cohort study

Baseline characteristics. Table S2. Baseline characteristics for patients eligible for routine TnI within 24 h of ICU admission. Table S3. Baseline characteristics: London dataset. Table S4. Coefficients and SE for whole dataset. Figure S1. Calibration plot for predicted vs actual probabilityof hospital mortality. Figure S2. Association of troponin I (in mg/L) with hospital mortality with interaction term for sex. (DOCX 93 kb

Diabetes according to age, sex, and admission glucose from time to event analyses.

<p>csHR (95% CI) derived from Cox regression model. sdHR (95% CI) derived from Fine and Gray regression model. Estimates are presented for all variables included in the models.</p

Glucose measurement on admission by patient characteristics.

a<p>All figures are counts (%) except for hospital, for which the proportion with glucose measures across hospitals was summarised using the median (interquartile range) and [range].</p

3-year risk of type 2 diabetes and competing risks.

<p>Estimates of 3-year risk of type 2 diabetes in women aged 60 obtained by multiplying the risk in women aged 60 with a glucose of 5 mmol/L (1.0%, obtained from the logistic regression model in <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001708#pmed-1001708-t004" target="_blank">Table 4</a>) by the csHR and the sdHR, respectively.</p

Mortality according to admission glucose.

<p>Hazard ratio (95% CI). Model 1 adjusts for age, age-squared, and sex. Model 2 additionally adjusts for SIMD quintile, comorbidity (Charlson Index), COPD, and medical speciality.</p><p>Results shown for glucose categorised and modelled as a polynomial.</p>a<p>Glucose 1.16 (1.07–1.25). Glucose-squared 0.42 (0.36–0.48) and glucose cubed 1.35 (1.29–1.41).</p>b<p>Glucose 1.24 (0.93–1.66). Glucose-squared 0.41 (0.27–0.63) and glucose cubed 1.40 (1.25–1.58).</p>c<p>Glucose 1.15 (1.05–1.24). Glucose-squared 0.43 (0.37–0.50) and glucose cubed 1.33 (1.27–1.39).</p

3-year risk of type 2 diabetes by admission glucose.

<p>The solid line represents the estimate and the ribbon represents the 95% CI obtained from a logistic regression model of incident type 2 diabetes on glucose, glucose-squared, and glucose-cubed. Points represent the risk of diabetes for patients categorised according to admission glucose, with the x-axis indicating the mean glucose level and the point size indicating the number of patients for each category.</p

Baseline characteristics by admission glucose.

<p>All data are <i>n</i> (%) except age, which is reported as mean (standard deviation).</p><p>Elevated WCC, white cell count ≥11×10⁹/l.</p

3-year risk of type 2 diabetes by glucose for patients in sub-groups.

<p>Predicted 3-year risks of type 2 diabetes by glucose level obtained from logistic regression models. All models adjust for age, sex, and a main term and interaction term with glucose for the relevant grouping variable (e.g., admission to ICU). Lines represent estimates and ribbons indicate 95% CIs with blue used to indicate membership of the relevant sub-group and red used to describe the remainder of the population.</p

3-year risk of type 2 diabetes stratified by admission glucose, age, and sex.

<p>All data are n (%).</p

CONSORT style flowchart of patients included in analysis.

<p>* This group of 86,634 patients includes the <i>n</i> = 122 whose glucose was >20 mmol/l and so were assumed to have prevalent diabetes.</p