Clinico-epidemiological profile and treatment outcome of lip cancer: a retrospective study from north India

Background: Aim of present study to evaluate the Clinico-epidemiological profile and treatment outcome of Lip Cancer. Methods: This was a retrospective study performed in our hospital. All necessary clinical and epidemiological details of the 11 cases diagnosed with lip cancer from January 2016 to December 2021 were analysed. Results: The total number of new malignant cases diagnosed as lip cancer between January 2016 and December 2021 were 11, which comprised 6 male (55%) and 5 (45%) female. The male-to-female ratio was (1.2:1). The most common histological type was SCC, i.e., in 9 (81.8%) of the total number of cases and BCC was in 2 patients (18.2%). Overall survival at 5 years was 89% in our study. Conclusions: In conclusion, we have reported higher levels of lip cancer among men and those above 45 years of age. The important prognostic factors for overall survival in these patients were cancer stages. Better survival is achieved with surgery alone in the early stages and with adjuvant radiotherapy in the later stages

Clinico-epidemiological profile and treatment outcome of pituitary adenomas: a retrospective study

Background: Aim of this study was to evaluate the clinico-epidemiological profile and treatment outcome of pituitary adenomas. Methods: This was a retrospective study performed in the department of Radiation Oncology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India, in which 30 cases diagnosed with pituitary adenoma from January 2016 to December 2021 were studied.  There clinical and epidemiological features, treatment, overall survival and follow-up data was analyzed. Results: Most patients were female in gender 17 (57%), and the incidence rate was higher in female patients than male. Microadenoma was seen in just 4 (13%) patients. Macroadenoma in 12 (40%) and giant tumours in 14 (47%). At three and five years, the overall survival rate was 92% and 83%, respectively. Additionally, patients who got adjuvant radiation had a higher overall survival rate (84% versus 76%, p=.833) than those who did not. Conclusions: Radiotherapy is an effective treatment for pituitary adenomas, able to achieve excellent disease control. Patients with pituitary adenomas should be identified at an early stage so that effective treatment can be implemented. Initial therapy is generally transsphenoidal surgery with irradiation reserved for patients who do not achieve adequate reduction in tumor size after surgery

doi:10.1155/2008/845934 Research Article Some Generalized Error Inequalities and Applications

We present a family of four-point quadrature rule, a generalization of Gauss-two point, Simpson’s 3/8, and Lobatto four-point quadrature rule for twice-differentiable mapping. Moreover, it is shown that the corresponding optimal quadrature formula presents better estimate in the context of four-point quadrature formulae of closed type. A unified treatment of error inequalities for different classes of function is also given. Copyright q 2008 F. Zafar and N. A. Mir. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

A Generalzation of Ostrowski-gruss Type Inequality for First Dierentiable Mappings

[[abstract]]In this paper, we improve and further generalize some Ostrowski- Gruss type inequalities involving rst dierentiable functions and apply them to probability density functions, generalized beta random variable and special means

A Note on the Generalization of Some New Čebyšev Type Inequalities

[[abstract]]In this paper, we present a generalized Cebyšev type inequality for absolutely continuous functions whose derivatives belong to L(subscript p) [a, b], p>1. Applications for probabilty density functions are also given

Agglomerative Clustering and Residual-VLAD Encoding for Human Action Recognition

Human action recognition has gathered significant attention in recent years due to its high demand in various application domains. In this work, we propose a novel codebook generation and hybrid encoding scheme for classification of action videos. The proposed scheme develops a discriminative codebook and a hybrid feature vector by encoding the features extracted from CNNs (convolutional neural networks). We explore different CNN architectures for extracting spatio-temporal features. We employ an agglomerative clustering approach for codebook generation, which intends to combine the advantages of global and class-specific codebooks. We propose a Residual Vector of Locally Aggregated Descriptors (R-VLAD) and fuse it with locality-based coding to form a hybrid feature vector. It provides a compact representation along with high order statistics. We evaluated our work on two publicly available standard benchmark datasets HMDB-51 and UCF-101. The proposed method achieves 72.6% and 96.2% on HMDB51 and UCF101, respectively. We conclude that the proposed scheme is able to boost recognition accuracy for human action recognition

Clinical Profile and Treatment Outcome of Chordoma: A Tertiary Care Experience in North India

Chordoma is a slow growing cancer of tissue found inside the spine. Chordoma can happen anywhere along the spine. It is most often found near the tailbone (called a sacral tumor) or where the spine meets the skull (called a clival tumor). Chordoma is also called notochordal sarcoma. The main objective of this study was to determine the clinical profile and treatment outcome of chordoma patients. All the patients were diagnosed using radiological imaging and biopsy. The site of origin of chordoma was the sacrum in seventeen (71%) patients, the spine in six (25%) patients, and the skull base in one (4%) patient. 21 (88%) of the twenty-four patients received primary surgery. These 21 patients then received adjuvant radiation therapy using the intensity modulated radiation therapy (IMRT) strategy, with radiation dose ranging from 70Gy to 74Gy. Three patients (12%) did not undergo surgery; two had low performance status and received only radiotherapy; the third with the disease at the base of the skull was unresectable; this patient received radiotherapy first, then imatinib. Compared to individuals who get radiation alone, the addition of adjuvant radiation therapy to surgery in chordoma patients enhances overall survival.Keywords: chordoma, radiotherapy, targeted therapy

Citrus peel as a source of functional ingredient: A review

AbstractCitrus plants belonging to the family Rutaceae which include fruits such as orange, mandarin, lime, lemon, sour orange and grapefruitappear as a well known promising source of multiple beneficial nutrients for human beings. Processing of citrus by-products potentially represents a rich source of phenolic compounds and dietary fibre, owing to the large amount of peel produced. These citrus fruit residues, which are generally discarded as waste in the environment, can act as potential nutraceutical resources. Due to their low cost and easy availability such wastes are capable of offering significant low-cost nutritional dietary supplements. The utilization of these bioactive rich citrus residues can provide an efficient, inexpensive, and environment friendly platform for the production of novel nutraceuticals or for the improvement of older ones. This review systematically summarized the potential components present in citrus peel, which generally discarded as waste

Time series analysis and short-term forecasting of monkeypox outbreak trends in the 10 major affected countries

Background: Considering the rapidly spreading monkeypox outbreak, WHO has declared a global health emergency. Still in the category of being endemic, the monkeypox disease shares numerous clinical characters with smallpox. This study focuses on determining the most effective combination of autoregressive integrated moving average model to encapsulate time dependent flow behaviour of the virus with short run prediction.Methods: This study includes the data of confirmed reported cases and cumulative cases from eight most burdened countries across the globe, over the span of May 18, 2022, to December 31, 2022. The data was assembled from the website of Our World in Data and it involves countries such as United States, Brazil, Spain, France, Colombia, Mexico, Peru, United Kingdom, Germany and Canada. The job of modelling and short-term forecasting is facilitated by the employment of autoregressive integrated moving average. The legitimacy of the estimated models is argued by offering numerous model performance indices such as, root mean square error, mean absolute error and mean absolute prediction error.Results: The best fit models were deduced for each country by using the data of confirmed reported cases of monkeypox infections. Based on diverse set of performance evaluation criteria, the best fit models were then employed to provide forecasting of next twenty days. Our results indicate that the USA is expected to be the hardest-hit country, with an average of 58 cases per day with 95% confidence interval of (00-400). The second most burdened country remained Brazil with expected average cases of 23 (00-130). The outlook is not much better for Spain and France, with average forecasts of 52 (00-241) and 24 (00-121), respectively.Conclusion: This research provides profile of ten most severely hit countries by monkeypox transmission around the world and thus assists in epidemiological management. The prediction trends indicate that the confirmed cases in the USA may exceed than other contemporaries. Based on the findings of this study, it remains plausible to recommend that more robust health surveillance strategy is required to control the transmission flow of the virus especially in USA