Baloch Insurgency and its impact on CPEC

CPEC, a significant development project, aims to connect Pakistan and China through highways, oil and gas pipelines, railways and an optical fiber link all the way from Gwadar to Xinjiang. Being the biggest venture in the bilateral ties of China-Pakistan, the project faces certain undermining factors. The research explores the lingering security concerns that surfaced due to the destabilizing and separatist efforts of the Baloch Liberation Army (BLA) and Baloch Liberation Front (BLF). It also elaborates the Chinese concerns and Pakistan efforts to address these concerns while assuming the hypothesis that a secure and stable environment is necessary to reap the fruits of this mega project. The work also answers some innovative questions thus helpful for the students of Economics, Pakistan history, politics, Internal Relations, Foreign Policy and for those who intend to read about China-Pakistan and their joint ventures as CPEC. The main objective of the study to empirically analyses the response of Baloch community. Graphical and empirical methods have been adopted to describe and analyze the facts and figures related to the topic. The results clearly indicate that CPEC will face resistance from people of Balochistan, which will negatively affect the prospects of CPEC. The results also indicate that social issues like migration should be tackle to increase the benefits. Furthermore, people think that such project is important for growth and development of the country

Investigation and exploitation of Mycosporine-like amino acids from Rhodophytes and bacteria

Pharmaceutical industries, especially skin-care related industries are focused on the development of new eco-friendly, affordable and photostable sunscreen formulations which possess potent photoprotective effects against the increasing levels of ultraviolet radiation exposure. The target in this study was ‘nature-inspired’ molecules from rhodophytes as well as microbial natural products structurally related to mycosporine-like amino acids (MAAs). The MAAs shinorine and porphyra-334 were purified from the commercially available HelioguardTM 365 whereas the cis-trans UVA absorbers namely usujirene/palythene were extracted from the edible rhodophyte Palmaria palmata, characterised using UHPLC-HRMS and 1H NMR and their photoprotective mechanism was determined with the collaboration of the Chemistry department, University of Warwick. A novel chemo-enzymatic procedure for accessing MAA-inspired metabolites was developed where the focal point of this research was the fourth enzyme, being a NRPS-like enzyme. Based on bioinformatic analyses, homologous enzymes containing NRPS-like domains with distinct substrate specificity were identified in the genome of diverse cyanobacteria where a new technique was proposed involving “A-domain” swapping in NRPS-like enzymes leading to novel recombinant enzymes that was projected to direct the biosynthesis of novel MAAs using a synthetic substrate, AC23, synthesized in the Chemistry department, University of Warwick. Furthermore, a plausible mechanism of the TE domain of the NRPS-like enzymes in this study was also proposed. Further research should be carried out, using the native substrate, namely mycosporine-glycine to confirm the functionality of the NRPS-like enzymes involved in this study. As such, NRPS-like enzymes engineering can be further explored and exploited to generate nature-inspired photoprotective natural products with desired properties for pharmaceutical industries as well as for benefiting human in counteracting the harmful effects of UV radiation

Baloch Insurgency and its impact on CPEC

CPEC, a significant development project, aims to connect Pakistan and China through highways, oil and gas pipelines, railways and an optical fiber link all the way from Gwadar to Xinjiang. Being the biggest venture in the bilateral ties of China-Pakistan, the project faces certain undermining factors. The research explores the lingering security concerns that surfaced due to the destabilizing and separatist efforts of the Baloch Liberation Army (BLA) and Baloch Liberation Front (BLF). It also elaborates the Chinese concerns and Pakistan efforts to address these concerns while assuming the hypothesis that a secure and stable environment is necessary to reap the fruits of this mega project. The work also answers some innovative questions thus helpful for the students of Economics, Pakistan history, politics, Internal Relations, Foreign Policy and for those who intend to read about China-Pakistan and their joint ventures as CPEC. The main objective of the study to empirically analyses the response of Baloch community. Graphical and empirical methods have been adopted to describe and analyze the facts and figures related to the topic. The results clearly indicate that CPEC will face resistance from people of Balochistan, which will negatively affect the prospects of CPEC. The results also indicate that social issues like migration should be tackle to increase the benefits. Furthermore, people think that such project is important for growth and development of the country

願書留（正月より十二月まで、名主上野新右衛門外）

Few quantifiable tissue biomarkers for the diagnosis and prognosis of prostate cancer exist. Using an unbiased, quantitative approach, this study evaluates the potential of three proteins of the 40S ribosomal protein complex as putative biomarkers of malignancy in prostate cancer. Prostate tissue arrays, constructed from 82 patient samples (245 tissue cores, stage pT3a or pT3b), were stained for antibodies against three ribosomal proteins, RPS19, RPS21 and RPS24. Semi-automated Ox-DAB signal quantification using ImageJ software revealed a significant change in expression of RPS19, RPS21 and RPS24 in malignant vs non-malignant tissue (p<0.0001). Receiver operating characteristics curves were calculated to evaluate the potential of each protein as a biomarker of malignancy in prostate cancer. Positive likelihood ratios for RPS19, RPS21 and RPS24 were calculated as 2.99, 4.21, and 2.56 respectively, indicating that the overexpression of the protein is correlated with the presence of disease. Triple-labelled, quantitative, immunofluorescence (with RPS19, RPS21 and RPS24) showed significant changes (p<0.01) in the global intersection coefficient, a measure of how often two fluorophore signals intersect, for RPS19 and RPS24 only. No change was observed in the co-localization of any other permutations of the three proteins. Our results show that RPS19, RPS21 or RPS24 are upregulated in malignant tissue and may serve as putative biomarkers for prostate cancer

Remembrance of Iqbal in Arabic Countries

Allama Muhammad Iqbal became popular after the translations of his work into Arabic .Scholars, thinkers, writers, and politicians of Arabia were very much influenced by his literary works. A number of books were written on him. Other scholars and Muslim thinkers study his works with keen interest even in the modern times. The universities and other institutions in the Arabian countries have concentrated and contributed in the establishment of academic studies on various aspects of his life, literary works and different translations. This article intended to briefly cover Seminars and celebrations commemorating Iqbal in the Arab countries

Celebrities in the Memory of Iqbal in Arabic Countries (Arabic)

Allama Muhammad Iqbal became popular after the translations of his work into Arabic .Scholars, thinkers, writers, and politicians of Arabia were very much influenced by his literary works. A number of books were written on him. Other scholars and Muslim thinkers study his works with keen interest even in the modern times. The universities and other institutions in the Arabian countries have concentrated and contributed in the establishment of academic studies on various aspects of his life, literary works and different translations. This article intended to briefly cover Seminars and celebrations commemorating Iqbal in the Arab countries

Muḥammad Iqbāl in the eyes of Arabic Litterateurs

Iqbāl is known as a revolutionary poet, and Islamic intellectual, a religious reformer, pioneer of Islamic awareness and a great leader of the Muslims of the sub-continent. He was introduced to the Arab world during the early part of 20th century and became popular after the translations of his work into Arabic. Scholars, thinkers, writers, and politicians of Arabia were very much influenced by his literary works. A number of books were written on him. Other scholars and Muslim thinkers study his works with keen interest even in the modern times. Iqbāl was paid rich tributes by Arab writers and thinkers for his unique wealth of literary works. In this article we present the views of Arabian writers about his literary status