17 research outputs found

    Optimized Transit Tool & Easy Reference (OTTER) Improved Data Analysis

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    NPS NRP Technical ReportOptimized Transit Tool & Easy Reference (OTTER) Improved Data AnalysisN4 - Fleet Readiness & LogisticsThis research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.

    Optimized Transit Tool & Easy Reference (OTTER) Improved Data Analysis

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    NPS NRP Executive SummaryOptimized Transit Tool & Easy Reference (OTTER) Improved Data AnalysisN4 - Fleet Readiness & LogisticsThis research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.

    Optimized Transit Tool & Easy Reference (OTTER) Improved Data Analysis

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    NPS NRP Project PosterOptimized Transit Tool & Easy Reference (OTTER) Improved Data AnalysisN4 - Fleet Readiness & LogisticsThis research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.

    EUCOM’s POL Capability & Capacity Gaps – Single Fuel Concept Follow On

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    NPS NRP Executive SummaryThis research effort will analyze fuel supply and distribution capabilities during Phase II operations in the European theater when operating under the single fuels concept. This effort will build on two prior works by the research team: the first study focused on the logistics benefit provided by the single fuel concept in the Pacific (UNCLAS); the second study explored the current logistics capability and capacity gaps surrounding POL distribution in the EUCOM theater (SECRET/NOFORN). The proposed study will explore how switching to a single fuel operational concept will impact those gaps and will address what policy could be changed and/or assets procured to lessen those capability gaps.N4 - Fleet Readiness & LogisticsThis research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.

    EUCOM’s POL Capability & Capacity Gaps – Single Fuel Concept Follow On

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    NPS NRP Project PosterThis research effort will analyze fuel supply and distribution capabilities during Phase II operations in the European theater when operating under the single fuels concept. This effort will build on two prior works by the research team: the first study focused on the logistics benefit provided by the single fuel concept in the Pacific (UNCLAS); the second study explored the current logistics capability and capacity gaps surrounding POL distribution in the EUCOM theater (SECRET/NOFORN). The proposed study will explore how switching to a single fuel operational concept will impact those gaps and will address what policy could be changed and/or assets procured to lessen those capability gaps.N4 - Fleet Readiness & LogisticsThis research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.

    Sustainable Energy at Coastal Facilities

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    NPS NRP Technical ReportThis research effort examined the paths to further adoption of sustainable energy at coastal facilities. It examined current technical, financial, legal, and policy challenges that have hindered past efforts to incorporate more renewable energy and that are priorities to be considered for future renewable energy projects. The research team gathered data and information through an examination of literature and interviews with subject matter experts familiar with coastal facilities and with experts in the renewable energy sector. The team conducted two case studies of US Coast Guard Station Monterey (CA) and Naval Air Station Corpus Christi (TX) to provide additional context for the adoption of sustainable renewable energy at coastal facilities. Additionally, research was conducted on mechanisms for microgrid financing to demonstrate how a facility may finance microgrid installation and further adoption of renewable energy and microgrids. Researchers found that there are some common core challenges for installing and using microgrids. These challenges include zoning issues, environmental considerations, infrastructure barriers, financing issues, conflicting safety standards, technical obstacles, and administrative hurdles. Researchers found that some challenges can be lessened, avoided, or accounted for with advance preparation and awareness ahead of time. Further analysis of region-specific challenges would provide more context for consideration of sustainable energy and implementation of microgrids. Further study is also required to understand the details of an appropriate financial acquisition agreement with a quantification of the benefits and costs of microgrids over time. Finally, the processes for contracting out microgrid design and construction and identifying suitable contractors is recommended.NAVFAC Engineering and Expeditionary Warfare CenterN4 - Fleet Readiness & LogisticsThis research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.

    Sustainable Energy at Coastal Facilities

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    NPS NRP Project PosterThis research effort examined the paths to further adoption of sustainable energy at coastal facilities. It examined current technical, financial, legal, and policy challenges that have hindered past efforts to incorporate more renewable energy and that are priorities to be considered for future renewable energy projects. The research team gathered data and information through an examination of literature and interviews with subject matter experts familiar with coastal facilities and with experts in the renewable energy sector. The team conducted two case studies of US Coast Guard Station Monterey (CA) and Naval Air Station Corpus Christi (TX) to provide additional context for the adoption of sustainable renewable energy at coastal facilities. Additionally, research was conducted on mechanisms for microgrid financing to demonstrate how a facility may finance microgrid installation and further adoption of renewable energy and microgrids. Researchers found that there are some common core challenges for installing and using microgrids. These challenges include zoning issues, environmental considerations, infrastructure barriers, financing issues, conflicting safety standards, technical obstacles, and administrative hurdles. Researchers found that some challenges can be lessened, avoided, or accounted for with advance preparation and awareness ahead of time. Further analysis of region-specific challenges would provide more context for consideration of sustainable energy and implementation of microgrids. Further study is also required to understand the details of an appropriate financial acquisition agreement with a quantification of the benefits and costs of microgrids over time. Finally, the processes for contracting out microgrid design and construction and identifying suitable contractors is recommended.NAVFAC Engineering and Expeditionary Warfare CenterN4 - Fleet Readiness & LogisticsThis research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.

    Sustainable Energy at Coastal Facilities

    Get PDF
    NPS NRP Executive SummaryThis research effort examined the paths to further adoption of sustainable energy at coastal facilities. It examined current technical, financial, legal, and policy challenges that have hindered past efforts to incorporate more renewable energy and that are priorities to be considered for future renewable energy projects. The research team gathered data and information through an examination of literature and interviews with subject matter experts familiar with coastal facilities and with experts in the renewable energy sector. The team conducted two case studies of US Coast Guard Station Monterey (CA) and Naval Air Station Corpus Christi (TX) to provide additional context for the adoption of sustainable renewable energy at coastal facilities. Additionally, research was conducted on mechanisms for microgrid financing to demonstrate how a facility may finance microgrid installation and further adoption of renewable energy and microgrids. Researchers found that there are some common core challenges for installing and using microgrids. These challenges include zoning issues, environmental considerations, infrastructure barriers, financing issues, conflicting safety standards, technical obstacles, and administrative hurdles. Researchers found that some challenges can be lessened, avoided, or accounted for with advance preparation and awareness ahead of time. Further analysis of region-specific challenges would provide more context for consideration of sustainable energy and implementation of microgrids. Further study is also required to understand the details of an appropriate financial acquisition agreement with a quantification of the benefits and costs of microgrids over time. Finally, the processes for contracting out microgrid design and construction and identifying suitable contractors is recommended.NAVFAC Engineering and Expeditionary Warfare CenterN4 - Fleet Readiness & LogisticsThis research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.

    Evaluating the links between schizophrenia and sleep and circadian rhythm disruption

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    Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor Îł2 subunit

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    The regulation of the number of γ2-subunit-containing GABAA receptors (GABAARs) present at synapses is critical for correct synaptic inhibition and animal behavior. This regulation occurs, in part, by the controlled removal of receptors from the membrane in clathrin-coated vesicles, but it remains unclear how clathrin recruitment to surface γ2-subunit-containing GABAARs is regulated. Here, we identify a γ2-subunit-specific Yxxφ-type-binding motif for the clathrin adaptor protein, AP2, which is located within a site for γ2-subunit tyrosine phosphorylation. Blocking GABAAR-AP2 interactions via this motif increases synaptic responses within minutes. Crystallographic and biochemical studies reveal that phosphorylation of the Yxxφ motif inhibits AP2 binding, leading to increased surface receptor number. In addition, the crystal structure provides an explanation for the high affinity of this motif for AP2 and suggests that γ2-subunit-containing heteromeric GABAARs may be internalized as dimers or multimers. These data define a mechanism for tyrosine kinase regulation of GABAAR surface levels and synaptic inhibition
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