Hierarchical gold nanostructures based sensor for sensitive and fast detection of cancer biomarker

Importance of precision diagnostics in healthcare has been ignited by the idea that early detection of cancer would immensely benefit patients in terms of more effective and timely treatment modality. Clinical samples in the form of biopsy specimen/serum/urine/saliva contains an ocean of diagnostic information to generate conclusive information for more precise and evidence-based options to manage cancer. However, to achieve this, there is a need detect biomarkers, that can provide significantly increased diagnostic accuracy. Nanobiosensors have undoubtedly boomed to claim ultrasensitive detection of DNA cancer biomarkers in attomolar and femtomolar range. However, ultrasensitive and accurate detection of protein biomarker is rare. This work describes fabrication of a hierarchical gold nano-biosensor (HAu) for ultra-sensitive detection of cancer protein biomarkers in pg/mL range. Unique chemical modification during electrochemical synthesis has rendered highly uniformed and dense nanostructures of gold on a solid platform. Factors affecting homogeneity and sensitivity of the sensing platform have been optimized in detail. Voltammetric sensing based on antibody-antigen interaction on the given sensing platform has demonstrated a wide linear range of detection for EGFR varying from 10 pg/mL to 1 ng/mL concentration

Hierarchical gold nanostructures based sensor for sensitive and fast detection of cancer biomarker

135-140Importance of precision diagnostics in healthcare has been ignited by the idea that early detection of cancer would immensely benefit patients in terms of more effective and timely treatment modality. Clinical samples in the form of biopsy specimen/serum/urine/saliva contains an ocean of diagnostic information to generate conclusive information for more precise and evidence-based options to manage cancer. However, to achieve this, there is a need detect biomarkers, that can provide significantly increased diagnostic accuracy. Nanobiosensors have undoubtedly boomed to claim ultrasensitive detection of DNA cancer biomarkers in attomolar and femtomolar range. However, ultrasensitive and accurate detection of protein biomarker is rare. This work describes fabrication of a hierarchical gold nano-biosensor (HAu) for ultra-sensitive detection of cancer protein biomarkers in pg/mL range. Unique chemical modification during electrochemical synthesis has rendered highly uniformed and dense nanostructures of gold on a solid platform. Factors affecting homogeneity and sensitivity of the sensing platform have been optimized in detail. Voltammetric sensing based on antibody-antigen interaction on the given sensing platform has demonstrated a wide linear range of detection for EGFR varying from 10 pg/mL to 1 ng/mL concentration

Rapid processing of wafer-scale anti-reflecting 3D hierarchical structures on silicon and its templation

Hierarchically structured silicon (Si) surfaces with a combination of micro/nano-structures are highly explored for their unique surface and optical properties. In this context, we propose a rapid and facile electroless method to realize hierarchical structures on an entire Si wafer of 3″ diameter. The overall process takes only 65 s to complete, unlike any conventional wet chemical approach that often combines a wet anisotropic etching of (100) Si followed by a metal nanoparticle catalyst etching. Hierarchical surface texturing on Si demonstrates a broadband highly reduced reflectance with average R% ~ 2.7% within 300⁻1400 nm wavelength. The as-fabricated hierarchical structured Si was also templated on a thin transparent layer of Polydimethylsiloxane (PDMS) that further demonstrated prospects for improved solar encapsulation with high optical clarity and low reflectance (90% and 2.8%)

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Not AvailableGround water is the major source of water supply in urban India. Understanding and assessment of groundwater quality for drinking and irrigation uses is therefore imperative to maintain its quality in any fast growing city like Bhubaneswar in Eastern India. A framework was developed in Visual Basic 6.0 software to generate quantifiable estimation of water use for drinking as well as irrigation purpose using different water quality parameters. Different forms have been prepared for water quality assessment and showing standard values for water quality parameters. Twenty different water quality parameters for drinking and nineteen water quality parameters for irrigation purposes were analyzed using 55 water samples of the study region. The total weightage of water quality parameters were analyzed in this software module. Different forms were created for entering the water quality parameters for evaluation. Formats have also been prepared for depicting desirable limits of different water quality parameters for indented purposes. This software module can be used as a ready-made package for assessing characteristic of water quality parameters for drinking as well as irrigation purposes.Not Availabl

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Not AvailableSustainable development and efficient management of groundwater resources require an effective information technology tool for the dissemination of information to different stakeholders. This will help to develop appropriate measures in improving the agricultural scenario of the state. The average groundwater development is only 26.14% (including domestic, agricultural and industrial uses) in Odisha as against 58% in India with wide inter-regional variability due to various socio-economic and hydro-geological constraints. There is a need for an information system tool for groundwater scenario in the state. A graphical user information system related to information on different aspects of groundwater development has been prepared. A district-wise information system has been prepared on different aspects such as groundwater availability, utilization, socio-economics, energy use pattern etc. using the available information from different sources. The specific variables included in the database are the groundwater recharge, natural losses, sector-wise utilization, groundwater development, aquifer properties such as draw-down, transmissivity etc. This information system will be useful for taking appropriate decisions for sustainable groundwater development for irrigation purposes in different parts of the state to increase the overall productivity.Not Availabl

Rearrangement of dithianylcyclobutachromanol derivatives to 1,2,2a,8,9,9a-hexahydrocyclobuta[b][1]benzoxepin-8,9-dione

A novel rearrangement of dithianylcyclobutachromanol derivative 3a on treatment with mercuric oxide and fluoroboric acid in aqueous tetrahydrofuran leads to 1,2,2a,8,9,9a-hexahydro-2a,9a-dimethylcyclobuta[b]-[1]benzoxepin-8,9-dione whose structure is established by X-ray analysis

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Groundwater development and energy use dynamics for irrigation in Odisha

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