Size distribution of TiO₂ suspension in NaCl determined by dynamic light scattering.

<p>Size distribution of TiO₂ suspension in NaCl determined by dynamic light scattering.</p

Titanium dosage in organs and urine performed by ICP-OES.

<p>N.D. Not determined</p><p>Each value represents mean from 6 independent experiments ± SD. For each suspension, 3 measurements were performed.</p><p>(*) represent a statistical difference (p<0.05).</p><p>Titanium dosage in organs and urine performed by ICP-OES.</p

HE optical microscopy analysisof TiO₂ agglomerates in target organs.

<p>(A) Liver, 1 day after treatment, (B) Liver, 56 days after treatment, (C) Lungs, 1 day after treatment, (D) Lungs, 56 days after treatment, (E) Spleen, 1 day after treatment, (F) Spleen, 56 days after treatment, (F) Kidney, 1 day after treatment, (G) Kidney, 56 days after treatment.</p

Data correlation in compartmental model.

<p>Data are represented as blue crosses. Means of data at each time are represented as pink dots. Confidence interval at 95% is represented by a dotted line (Mean ± 1.96 × SD). Results obtained with the compartmental model are represented as a black line.</p

Schematic representation of the kinetic models.

<p>Schematic representation of the kinetic models.</p

Transmission electron microscopy analysis and energy dispersive X ray microanalysis spectrum of TiO₂ agglomerates in urine, liver, spleen and kidneys 28 days after intravenous injection.

<p>Transmission electron microscopy analysis and energy dispersive X ray microanalysis spectrum of TiO₂ agglomerates in urine, liver, spleen and kidneys 28 days after intravenous injection.</p