Metal-free synthesis of 2-aminothiadiazoles <i>via</i> TBHP-Mediated oxidative C-S bond formation

<p>An efficient one-pot synthesis of 2-amino-1,3,4-thiadiazoles from easily available aldehydes and thiosemicarbazide using TBHP as an oxidant has been described. Notably, these reactions were carried out at room temperature using ethanol as solvent. This is the first example for one-pot synthesis of 2-amino-1,3,4-thiadiazole derivatives from aldehydes. This new synthetic methodology provides a simple procedure utilizing a safer oxidizing system that affords the target products in mild reaction condition with satisfactory yields and wide substrate scope.</p

Unlocking the potential of nanobiohybrids to combat environmental pollution

The destructive effects of the world's population growth, which have led to the overuse of primary resources, are evident today. Recently, the world has hit an 8 billion population mark, which is accompanied by an increase in waste generation. Anthropogenic activities lead to environmental pollution that is a problem of great importance, and it is essential to develop economically sound, eco-friendly, and sustainable technologies to tackle this ever-increasing problem of the 21st century. Innovations are required since they can contribute to the creation of sophisticated, sustainable, and novel goods for ecological repair. Such properties can be seen in the current advancements of nanotechnologies and new performing nanomaterials. They have a substantial surface area, enzymatic activity, and responsiveness and are easily functionalized to chemically modify their characteristics. This chapter examines current advancements in bioremediation methods used in conjunction with various nanocomposites and nanobiohybrids to recover the environment from pollution. Special focus is placed on environmentally friendly and regenerative nanosolutions, as well as their secure properties

Essential oils for clinical aromatherapy: a comprehensive review

Ethnopharmacological relevanceAromatherapy, a holistic healing practice utilizing the aromatic essences of plant-derived essential oils, has gained significant attention for its therapeutic potential in promoting overall well-being. Use of phytoconstituent based essential oil has played a significant role in the evolving therapeutic avenue of aromatherapy as a complementary system of medicine.Aim of the study: This comprehensive review article aims to explore the usage of essential oils for aromatherapy, shedding light on their diverse applications, scientific evidence, and safety considerations. Furthermore, the growing interest in using essential oils as complementary therapies in conjunction with conventional medicine is explored, underscoring the significance of collaborative healthcare approaches.Materials and methodsLiterature search was performed from databases like PubMed, ScienceDirect, Scopus, and Bentham using keywords like Aromatherapy, Aromatic Plants, Essential oils, Phytotherapy, and complementary medicine. The keywords were used to identify literature with therapeutic and mechanistic details of herbal agents with desired action.ResultsThe integration of traditional knowledge with modern scientific research has led to a renewed interest in essential oils as valuable tools in contemporary healthcare. Various extraction methods used to obtain essential oils are presented, emphasizing their impact on the oil's chemical composition and therapeutic properties. Additionally, the article scrutinizes the factors influencing the quality and purity of essential oils, elucidating the significance of standardization and certification for safe usage. A comprehensive assessment of the therapeutic effects of essential oils is provided, encompassing their potential as antimicrobial, analgesic, anxiolytic, and anti-inflammatory agents, among others. Clinical trials and preclinical studies are discussed to consolidate the existing evidence on their efficacy in treating diverse health conditions, both physical and psychological. Safety considerations are of paramount importance when employing essential oils, and this review addresses potential adverse effects, contraindications, and best practices to ensure responsible usage.ConclusionsThis comprehensive review provides valuable insights into the exploration of essential oils for aromatherapy, emphasizing their potential as natural and potent remedies for a wide range of ailments. By amalgamating traditional wisdom and modern research, this article aims to encourage further investigation into the therapeutic benefits of essential oils while advocating for their responsible and evidence-based incorporation into healthcare practices.<br/