Flow diagram for study selection in accordance with PRISMA guidelines.

<p>Flow diagram for study selection in accordance with PRISMA guidelines.</p

Baseline Medication Use of Included Trials.

<p>Baseline Medication Use of Included Trials.</p

Baseline Characteristics of Included Trials.

<p>Baseline Characteristics of Included Trials.</p

Surface under the cumulative ranking curve plots for all treatments in the stroke prophylaxis network.

<p><i>Panel A</i>: Rankogram for Ischemic Stroke, <i>Panel B</i>: Rankogram for Major Bleeding, <i>Panel C</i>: Rankogram for Primary Safety Endpoint. <i>VKA = Dose-adjusted vitamin K antagonists</i>.</p

Interval plot for ischemic stroke in the stroke prophylaxis network.

<p><i>Panel A</i>: Ischemic Stroke, <i>Panel B</i>: Major Bleeding, <i>Panel C</i>: Primary Safety Endpoint. The solid black lines represent the confidence intervals for summary odds ratios for each comparison. The blue line is the line of no effect (odds ratio equal to 1). <i>VKA = Dose-adjusted vitamin K antagonists</i>.</p