The contribution of Qumran to historical Hebrew linguistics: Evidence from the syntax of participial negation

In this article we examine how Qumran Hebrew can contribute to our knowledge of historical Hebrew linguistics. The premise of this paper is that Qumran Hebrew reflects a distinct stage in the development of Hebrew which sets it apart from Biblical Hebrew. It is further assumed that these unique features are able to assist us to understand the nature of the development of Biblical Hebrew in a more precise way. Evidence from the syntax of participial negation at Qumran as opposed to Biblical Hebrew provides evidence for this claim

The experiences of postgraduate psychology students regarding the development of multicultural competence

This study investigated the experiences of postgraduate psychology students regarding their multicultural competence development (MCCD). King and Baxter Magolda’s multidimensional framework for the development of intercultural maturity, comprising cognitive, interpersonal and intrapersonal dimensions served as theoretical grounding. A qualitative, case study design was employed, using thematic analysis to analyse focus group data. It was found MCCD takes place across the lifespan and in various contexts. Methods to overcome obstacles to MCCD were identified, as well as the participants’ positions of MCCD. Lastly, educational experiences that promote MCCD are discussed

It’s a Virtual Child!: Postgraduate students’ experiences in a developmental psychology class

The aim of this study was to explore postgraduate psychology students’ development, as facilitated by the use of an interactive web-based simulation programme, My Virtual Child©. A social constructivist developmental approach, with specific focus on cognitive development towards self-authorship, served as the overarching framework for the study. Participants included postgraduate students enrolled in a developmental psychology module. Multiple sources of data, such as reflective exercises, summative portfolio assignments and a focus group, were analysed using thematic analysis. Participants indicated that the My Virtual Child© programme provided them with an excellent opportunity for authentic, relevant and challenging learning experiences, whilst balancing theory and practice. Furthermore, it provided room for deliberate reflective activities, group interaction and the integration of a diversity of experiences. This programme therefore created a practical and pragmatic teaching environment for more engaging and theoretically rich learning, preparing students for self-authorship in a complex world

Editorial theory and the range of translations for ‘cedars of Lebanon’ in the Septuagint

Although the Hebrew source text term אֶרֶז [cedar] is translated in the majority of cases as κέδρος [cedar] or its adjective κέδρινος in the Septuagint, there are cases where the following translations and strategies are used: (1) κυπάρισσος [cypress] or the related adjective κυπαρίσσινος, (2) ξύλον [wood, tree] and (3) non-translation and deletion of the source text item. This article focuses on these range of translations. Using a complexity theoretical approach in the context of editorial theory (the new science of exploring texts in their manuscript contexts), this article seeks to provide explanations for the various translation choices (other than κέδρος and κέδρινος). It further aims to determine which cultural values of the translators have influenced those choices and how they shape the metaphorical and symbolic meaning of plants as determined by Biblical Plant Hermeneutics, which has placed the taxonomy of flora on a strong ethnological and ethnobotanical basis

Is the adjective distinct from the noun as a grammatical category in biblical Hebrew?

The adjective is a beleaguered category in biblical Hebrew grammar with many grammars of biblical Hebrew denying that the adjective is a category distinct from substantives. Within a variety of linguistic theories, the status of the adjective as a grammatical category is also debated. Cross-linguistically adjectives exhibit extraordinary variety: in some languages showing similarities to nouns, in others to verbs and in still others to both nouns and verbs. The debate concerning the status of the adjective is mirrored by the broader debate within contemporary linguistics concerning how the issue of grammatical categorisation ought to be approached. In this article, we re-examine the question of whether or not the adjective is a distinct grammatical category from the noun in biblical Hebrew. We approach the question of the status of the adjective as a grammatical category from two perspectives: morphology and syntax

Die rol van taalvaardigheid in die verband tussen matrieken universiteitsprestasie van swart eerstejaarstudente

This article highlights some of the factors that play a role in the academic success of black first year students who receive non mother-tongue education in English. Students in the Faculties of Economic and Management Sciences, Natural and Agricultural Sciences, as well as the Humanities/Law at the University of the Free State were involved in the study. It was evident that both matric performance and language ability have predictive value. It was also found that the predictive value of these variables differed between the various faculties (which implies that students’ field of study should be taken into account when decisions regarding access with success is made).Key words: language proficiency, matric performance, academic achievement, non mother-tongue education, black first year students.Hierdie artikel werp lig op sommige faktore wat ’n rol speel in die akademiese prestasie van swart eerstejaarstudente wat nie-moedertaalonderrig in Engels ontvang. Studente in die Fakulteite Ekonomiese en Bestuurswetenskappe, Natuur- en Landbouwetenskappe, asook Geesteswetenskappe/Regte aan die Universiteit van die Vrystaat is by die studie betrek. Dit het geblyk dat beide matriekprestasie en taalvaardigheid voorspellingswaarde het. Verder is ook bevind dat die voorspellingswaarde van hierdie veranderlikes verskil tussen verskillende fakulteite (wat impliseer dat studente se studieveld in ag geneem moet word wanneer besluite rakende toelating met sukses geneem word).Sleutelwoorde: taalvaardigheid; matriekprestasie; akademiese prestasie; niemoedertaalonderrig, swart eerstejaarstudente.The article is in Afrikaans

Iron chelators inhibit amyloid-beta-induced production of lipocalin 2 in cultured astrocytes

Lipocalin 2 (Lcn2) has been implicated to play a role in various neurodegenerative diseases, and normalizing its overexpression may be of therapeutic potential. Iron chelators were found to reduce Lcn2 levels in certain animal models of CNS injury. Focusing on Alzheimer's disease (AD), we found that the iron chelators deferoxamine and deferiprone inhibited amyloid-β (Aβ)-induced Lcn2 production in cultured primary astrocytes. Accordingly, Aβ-exposure increased astrocytic ferritin production, indicating the possibility that Aβ induces iron accumulation in astrocytes. This effect was not significantly modulated by Lcn2. Known neuroprotective effects of iron chelators may rely in part on normalization of Lcn2 levels

Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases

Chronic (neuro)inflammation plays an important role in many age-related central nervous system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular dementia. Inflammation also characterizes many conditions that form a risk factor for these CNS disorders, such as physical inactivity, obesity and cardiovascular disease. Lipocalin 2 (Lcn2) is an inflammatory protein shown to be involved in different age-related CNS diseases, as well as risk factor conditions thereof. Lcn2 expression is increased in the periphery and the brain in different age-related CNS diseases and also their risk factor conditions. Experimental studies indicate that Lcn2 contributes to various neuropathophysiological processes of age-related CNS diseases, including exacerbated neuroinflammation, cell death and iron dysregulation, which may negatively impact cognitive function. We hypothesize that increased Lcn2 levels as a result of age-related risk factor conditions may sensitize the brain and increase the risk to develop age-related CNS diseases. In this review we first provide a comprehensive overview of the known functions of Lcn2, and its effects in the CNS. Subsequently, this review explores Lcn2 as a potential (neuro)inflammatory link between different risk factor conditions and the development of age-related CNS disorders. Altogether, evidence convincingly indicates Lcn2 as a key constituent in ageing and age-related brain diseases

Targeting TNFR2 as a novel therapeutic strategy for Alzheimer's disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Accumulating experimental evidence shows the important linkage between tumor necrosis factor-α (TNF) and AD, but the exact role of TNF in AD is still not completely understood. Although TNF-inhibitors are successfully used for treating several diseases, total inhibition of TNF can cause side effects, particularly in neurological diseases. This is attributed to the opposing roles of the two TNF receptors. TNF receptor 1 (TNFR1) predominantly mediates inflammatory and pro-apoptotic signaling pathways, whereas TNF receptor 2 (TNFR2) is neuroprotective and promotes tissue regeneration. Therefore, the specific activation of TNFR2 signaling, either by directly targeting TNFR2 via TNFR2 agonists or by blocking TNFR1 signaling with TNFR1-selective antagonists, seems a promising strategy for AD therapy. This mini-review discusses the involvement of TNFR2 and its signaling pathway in AD and outlines its potential application as therapeutic target. A better understanding of the function of TNFR2 may lead to the development of a treatment for AD

Antithrombotic/anticoagulant and anticancer activities of selected medicinal plants from South Africa

Nine plants available in the Eastern Cape Province of South Africa were tested for antithrombotic and/or anticoagulant activity. Organic (methanol) and aqueous (distilled water) extractions were performed on the various plant parts. The thrombin assay and clotting time assays (thrombin-induced and CaCl 2 -induced) were utilised. Several extracts displayed activity, but in most cases this was due to the presence of tannins. Only the aqueous extracts displayed activity after tannin removal. The Sutherlandia frutescens leaf extract displayed antithrombotic activity, with an IC 50 value of 2.17 mg/ml. Gloriosa superba and Zantedeschia aethiopica leaf extracts displayed anticoagulant properties by inhibiting thrombin-induced clotting, with IC 50 values of 2.97 and 3.05 mg/ml, respectively. The Leonotis leonurus root extract was found to decrease the CaCl 2 -induced clotting time by 50% at 8.88 mg/ml. A decrease in this value accompanied by a decrease in fibrin formation was preferable for the CaCl 2 -induced assay, since decreased fibrin formation may have a role in the prevention of cancer metastasis. As tannins were found to contribute minimally to the anticoagulant effect of L. leonurus, the cytotoxicity potential of the extracts of this species against five cell lines was determined. Only the organic extract yielded significant cytotoxity