Energy and system dependence of high-pTp_T triggered two-particle near-side correlations

Previous studies have indicated that the near-side peak of high-$p_T$ triggered correlations can be decomposed into two parts, the \textit{Jet} and the \textit{Ridge}. We present data on the yield per trigger of the \textit{Jet} and the \textit{Ridge} from $d+Au$, $Cu+Cu$ and $Au+Au$ collisions at $\sqrt{s_{NN}}$ = 62.4 GeV and 200 GeV and compare data on the \textit{Jet} to PYTHIA 8.1 simulations for $p+p$. PYTHIA describes the \textit{Jet} component up to a scaling factor, meaning that PYTHIA can provide a better understanding of the \textit{Ridge} by giving insight into the effects of the kinematic cuts. We present collision energy and system dependence of the \textit{Ridge} yield, which should help distinguish models for the production mechanism of the \textit{Ridge}.Comment: 4 pages, 6 figures, proceedings for Hot Quarks in Estes Park, Colorad

High pT correlations with strange particles in STAR

We present the highlights of the current identified strange particles DeltaPhi and DeltaEta correlations analyses, including system-size and trigger-pT of the jet and ridge, jet, ridge and away-side meson/baryon ratios, and the current state of the multi-strange baryon analysis. We see clear azimuthal peaks of comparable strength for all strange baryons and K0-short mesons. We see no observable species dependence on the same-side jet or ridge yields as a function of pT. However, while the away side and the ridge have Lambda to K0-short ratio similar to that of the bulk, the jet-only ratio is similar to that in $p+p$. The implications of these findings on current in-medium jet theoretical explanations are discussed.Comment: Proceedings for the Strangeness in Quark Matter 2007 Conference in Levoca, Slovaki

Activation of Flucloxacillin-Specific CD8+ T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model

There are currently no animal models of drug-induced liver injury (DILI) where the adaptive immune system has been shown to damage the liver. Thus, it is difficult to explore the mechanistic basis of the tissue injury. The aim of this study was to use C57BL/6 CD4+-deficient mice with a mutation in the αβ gene encoding for Major histocompatibilty complex (MHC) class II molecules to (1) develop a mouse model of flucloxacillin sensitization, (2) explore whether drug-specific CD8+ kill primary hepatocytes, and (3) analyze perturbations in liver integrity following oral exposure to flucloxacillin. CD8+ T-cells from lymph nodes of flucloxacillin-sensitized mice were stimulated to proliferate, secrete interferon (IFN-γ) and granzyme B, and induce hepatocyte apoptosis in a concentration-dependent manner following ex vivo stimulation. The T-cell response was antigen-specific; T-cells were not activated with other β-lactam antibiotics. Furthermore, T-cell responses only occurred in the presence of flucloxacillin-pulsed antigen presenting cells. In separate experiments, flucloxacillin-specific T-cells were induced to migrate to the mesenteric lymph nodes using retinoic acid, prior to administration of oral flucloxacillin, and analysis of plasma biomarkers of liver injury. Oral exposure to flucloxacillin resulted in mild elevations in alanine aminotransferase, liver, and gall bladder leukocyte infiltration and a marked swelling of the gall bladder. Thus, CD4+-deficient mice represent a promising model to study the role of the adaptive immune system in DIL

Gene expression studies of developing bovine longissimus muscle from two different beef cattle breeds

Background: The muscle fiber number and fiber composition of muscle is largely determined during prenatal development. In order to discover genes that are involved in determining adult muscle phenotypes, we studied the gene expression profile of developing fetal bovine longissimus muscle from animals with two different genetic backgrounds using a bovine cDNA microarray. Fetal longissimus muscle was sampled at 4 stages of myogenesis and muscle maturation: primary myogenesis (d 60), secondary myogenesis (d 135), as well as beginning (d 195) and final stages (birth) of functional differentiation of muscle fibers. All fetuses and newborns (total n = 24) were from Hereford dams and crossed with either Wagyu (high intramuscular fat) or Piedmontese (GDF8 mutant) sires, genotypes that vary markedly in muscle and compositional characteristics later in postnatal life. Results: We obtained expression profiles of three individuals for each time point and genotype to allow comparisons across time and between sire breeds. Quantitative reverse transcription-PCR analysis of RNA from developing longissimus muscle was able to validate the differential expression patterns observed for a selection of differentially expressed genes, with one exception. We detected large-scale changes in temporal gene expression between the four developmental stages in genes coding for extracellular matrix and for muscle fiber structural and metabolic proteins. FSTL1 and IGFBP5 were two genes implicated in growth and differentiation that showed developmentally regulated expression levels in fetal muscle. An abundantly expressed gene with no functional annotation was found to be developmentally regulated in the same manner as muscle structural proteins. We also observed differences in gene expression profiles between the two different sire breeds. Wagyu-sired calves showed higher expression of fatty acid binding protein 5 (FABP5) RNA at birth. The developing longissimus muscle of fetuses carrying the Piedmontese mutation shows an emphasis on glycolytic muscle biochemistry and a large-scale up-regulation of the translational machinery at birth. We also document evidence for timing differences in differentiation events between the two breeds. Conclusion: Taken together, these findings provide a detailed description of molecular events accompanying skeletal muscle differentiation in the bovine, as well as gene expression differences that may underpin the phenotype differences between the two breeds. In addition, this study has highlighted a non-coding RNA, which is abundantly expressed and developmentally regulated in bovine fetal muscle

Exploring Early Parton Momentum Distribution with the Ridge from the Near-Side Jet

In a central nucleus-nucleus collision at high-energies, medium partons kicked by a near-side jet acquire a momentum along the jet direction and subsequently materialize as the observed ridge particles. They carry direct information on the early parton momentum distribution which can be extracted by using the ridge data for central AuAu collisions at \sqrt{s_{NN}}=200 GeV. The extracted parton momentum distribution has a thermal-like transverse momentum distribution but a non-Gaussian, relatively flat rapidity distribution at mid-rapidity with sharp kinematic boundaries at large rapidities that depend on the transverse momentum.Comment: In Proceedings of 20th International Conference on Ultra-Relativistic Nucleus Nucleus Collisions, Jaipur, India, Feb. 4-10, 200

Remifentanil in the Horse: Identification and Detection of its Major Urinary Metabolite

Remifentanil (4-methoxycarbonyl-4-[(1-oxopropyl)phyenylamino]-1- piperidinepropionic acid methyl ester) is a μ-opioid receptor agonist with considerable abuse potential in racing horses. The identification of its major equine urinary metabolite, 4-methoxycarbonyl-4-[(1- oxopropyl)phenylamino]-1-piperidinepropionic acid, an ester hydrolysis product of remifentanil is reported. Administration of remifentanil HCl (5 mg, intravenous) produced clear-cut locomotor responses, establishing the clinical efficacy of this dose. ELISA analysis of postadministration urine samples readily detected fentanyl equivalents in these samples. Mass spectrometric analysis, using solid-phase extraction and trimethylsilyl (TMS) derivatization, showed the urine samples contained parent remifentanil in low concentrations, peaking at 1 h. More significantly, a major peak was identified as representing 4-methoxycarbonyl-4-[(1-oxopropyl)phenylamino]-1- piperidinepropionic acid, arising from ester hydrolysis of remifentanil. This metabolite reached its maximal urinary concentrations at 1 h and was present at up to 10-fold greater concentrations than parent remifentanil. Base hydrolysis of remifentanil yielded a carboxylic acid with the same mass spectral characteristics as those of the equine metabolite. In summary, these data indicate that remifentanil administration results in the appearance of readily detectable amounts of 4-methoxycarbonyl-4-[(1-oxopropyl)phenylamino]- 1-piperidinepropionic acid in urine. On this basis, screening and confirmation tests for this equine urinary metabolite should be optimized for forensic control of remifentanil

STAR results on medium properties and response of the medium to energetic partons

We report new STAR results on the consequences of highly energetic partons propagating through the medium formed in heavy ion collisions using correlations as an experimental probe. The recent results providing insights about color factor effects and path length dependence of parton energy loss, system size dependence of di-hadron fragmentation functions, conical emission and ridge formation in heavy ion collisions are presented.Comment: STAR Plenary talk at QM2008. Manuscript for the Proceedings of Quark Matter 2008, Jaipur, Indi