Dynamical SUSY Breaking in Meta-Stable Vacua

Dynamical supersymmetry breaking in a long-lived meta-stable vacuum is a phenomenologically viable possibility. This relatively unexplored avenue leads to many new models of dynamical supersymmetry breaking. Here, we present a surprisingly simple class of models with meta-stable dynamical supersymmetry breaking: N=1 supersymmetric QCD, with massive flavors. Though these theories are strongly coupled, we definitively demonstrate the existence of meta-stable vacua by using the free-magnetic dual. Model building challenges, such as large flavor symmetries and the absence of an R-symmetry, are easily accommodated in these theories. Their simplicity also suggests that broken supersymmetry is generic in supersymmetric field theory and in the landscape of string vacua.Comment: 48 pages, 1 figure, added discussion about the spectrum and some cosmological implication

A Novel Long-Acting Human Growth Hormone Fusion Protein (VRS-317): Enhanced In Vivo Potency and Half-Life

ABSTRACT:A novel recombinant human growth hormone (rhGH) fusion protein (VRS-317) was designed to minimize receptor-mediated clearance through a reduction in receptor binding without mutations to rhGH by genetically fusing with XTEN amino acid sequences to the N-terminus and the C-terminus of the native hGH sequence. Although in vitro potency of VRS-317 was reduced approximately 12-fold compared with rhGH, in vivo potency was increased because of the greatly prolonged exposure to the target tissues and organs. VRS-317 was threefold more potent than daily rhGH in hypophysectomized rats and fivefold more potent than daily rhGH in juvenile monkeys. In juvenile monkeys, a monthly dose of 1.4mg/kg VRS-317 (equivalent to 0.26mg/kg rhGH) caused a sustained pharmacodynamic response for 1month equivalent to 0.05mg/kg/day rhGH (1.4mg/kg rhGH total over 28days). In monkeys, VRS-317, having a terminal elimination half-life of approximately 110h, was rapidly and near-completely absorbed, and was well tolerated with no observed adverse effects after every alternate week subcutaneous dosing for 14weeks. VRS-317 also did not cause lipoatrophy in pig and monkey studies. VRS-317 is currently being studied in GH-deficient patients to confirm the observations in these animal studies. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Associatio

Chiral Rings and Phases of Supersymmetric Gauge Theories

We solve for the expectation values of chiral operators in supersymmetric U(N) gauge theories with matter in the adjoint, fundamental and anti-fundamental representations. A simple geometric picture emerges involving a description by a meromorphic one-form on a Riemann surface. The equations of motion are equivalent to a condition on the integrality of periods of this form. The solution indicates that all semiclassical phases with the same number of U(1) factors are continuously connected.Comment: 55 page

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Social Networks of Researchers and Educators on nanoHUB.org

The science gateway nanoHUB.org is the world’s largest nanotechnology user facility, serving 167,196 users in 2010 with over 2,300 resources including 189 simulation programs. Surveys of nanoHUB users and automated usage analysis find widespread simulation use in formal classroom education, thereby connecting recent research more rapidly and closely to education. Analysis of 719 citations in the scientific literature by over 1,300 authors to nanoHUB.org resources documents use of simulation programs by new research collaborations, by researchers outside of the community originating the program, and by experimentalists. The publication and author networks reveal research collaborations and capacity building through knowledge transfer. Analysis of secondary citations documents the quality of the conducted research with an h-index of 30 after just 10 years of operation. Our analysis proves with quantitative metrics that impactful research can be conducted by an ever growing research community. We argue that HUBzero technology and the user- focused design and operation of nanoHUB.org are success criteria that can be transferred to other science gateways

Multi-tissue δ2H analysis reveals altitudinal migration and tissue-specific discrimination patterns in Cinclodes

© 2015 Newsome et al. One of the fastest growing uses of stable isotope analysis in ecology is using hydrogen isotope (δ2H) values to characterize animal movement and migration strategies. Most studies measure δ2H values in metabolically inert tissues such as feathers, which are typically grown during or just after the summer breeding season and provide a limited snapshot of an individual's annual life history. In contrast, isotopic analysis of metabolically active tissues can provide ecological information integrated over weeks to months prior to sampling. Here we characterize δ2H patterns among multiple metabolically inert and active tissues in Cinclodes, a genus of South American songbirds noted for variation in altitudinal movement and foraging strategies. We also coupled δ2H with carbon (δ13C) and nitrogen (δ15N) isotope data to combine information on movement with marine versus terrestrial resource use at the individual level. We find that a combination of physiological and ecol

Impact of increased wood pellet demand on biodiversity in the south-eastern United States

Increasing wood pellet exports from the United States are projected to lead to changes in land use and timberland management, including a shift from natural timberland to pine plantations. These projected changes may impact biodiversity. This study aims to quantify potential biodiversity impacts of increased wood pellet demand in the south-eastern United States in a spatially explicit manner. We determined differences according to an index of potential species richness (for total, threatened and endemic species and four taxonomic groups) between scenarios of high and low demand for wood pellets, while taking into account potential developments in other wood markets and other land uses. Increased demand for wood pellets was projected to cause both positive and negative biodiversity impacts. Negative shifts in total potential species richness were projected for areas in Florida, coastal Virginia and North Carolina, and parts of the Gulf Coast. Positive shifts in total potential species richness were projected in parts of Oklahoma and Arkansas. In some locations, the direction of change differed per taxonomic group, highlighting the importance of analysing different taxonomic groups. Shifts in potential species richness due to increased wood pellet demand were considerably smaller compared to the changes due to other drivers, such as urbanization and increased timber demand. Biodiversity impacts due to wood pellet demand should therefore be considered in the context of other drivers of land-use change and biodiversity loss. Our results provide information that allows policymakers, industry and NGOs to focus on areas of concern and take appropriate mitigation measures to limit negative biodiversity impacts and promote positive impacts. The spatially explicit approach presented in this study can be applied to different regions and drivers of land-use change, to show how projected demand for an internationally traded commodity may lead to impacts on land use and biodiversity in the procurement region