Service Delivery Principles and Techniques: Helping People Experiencing Homelessness Engage in Services and Succeed in Employment

Individuals experiencing or at risk of homelessness are motivated to engage in services, employment and other life changes at different times and in different ways. Understanding how to meet people where they are and help foster the process of change can bolster program successes with people experiencing homelessness

Populations Experiencing Homelessness: Diverse Barriers to Employment and How to Address Them

People experience homelessness for many reasons including financial insecurity, a lack of affordable housing, and difficulty accessing services such as medical care. Effective employment programs take special care when serving individuals facing these barriers. This best practice brief outlines the common employment barriers for these populations and provides considerations for tailoring employment services and prioritizing supportive services to best meet their needs

Employment Program Models for People Experiencing Homelessness: Different approaches to program structure

Most individuals experiencing or at risk of homelessness want to work and a growing number of service providers and policymakers have taken notice. Although choosing the right employment program model can seem like a daunting task, research and wisdom from the field shows that multiple models have proven effective or promising in attaching the most disadvantaged jobseekers to work and helping them advance to employment options that meet their long-term needs and interests. Additionally, these models can be helpful in building upon existing skills or developing new skills necessary to enter and succeed in employment today. This best practice brief highlights what is known about these employment approaches to attachment and advancement, covering each model's purpose, elements, principles, funding, and research evidence, with examples from the field

Employment Program Components: Considerations for Modifying Programming for People Experiencing Homelessness

Employment programs typically include assessment, job search assistance, work readiness training, occupational training, job placement, and retention services. Research and experience suggest that programs can best meet individual needs, strengths, and interests by modifying these elements to ensure flexible services that support each individual's personal and developmental needs as they transition to employment. This best practice brief highlights a menu of enhancements and examples that programs may consider in providing supportive, flexible services for individuals experiencing or at risk of homelessness

IR, Raman, and NMR Studies of the Short-Range Structures of 0.5Na2S + 0.5[xGeS2 + (1–x)PS5/2] Mixed Glass-Former Glasses

A nonlinear and nonadditive composition-dependent change of the ionic conductivity in mixed glass-former (MGF) glasses when one glass former, such as PS5/2, is replaced by a second glass former, such as GeS2, at constant alkali modifier concentrations, such as Na2S, is known as the mixed glass-former effect (MGFE). Alkali ion conducting glasses are of particular interest for use as solid electrolytes in alkali-based all-solid-state batteries because sulfide amorphous materials have significantly higher alkali ion conductivities than their oxide glass counterparts. In this study of the ternary MGF system Na2S + GeS2 + PS5/2, we report the careful structural characterization of these glasses using a combination of vibrational, infrared (IR), Raman, and nuclear magnetic resonance (NMR) spectroscopies. Our measurements of the 0.5Na2S + 0.5[xGeS2 + (1–x)PS5/2] MGF system show that this glass system exhibits a strongly negative MGFE and non-Arrhenius ionic conductivities. While this negative MGFE in the Na+ ion conductivity makes these glasses less attractive for use in solid-state Na batteries, the structural origin of this effect is important to better understand the mechanisms of ion conduction in the glassy state. For these reasons, we have examined the structures of ternary 0.5Na2S + 0.5[xGeS2 + (1–x)PS5/2] glasses using Raman, IR, and 31P MAS NMR spectroscopies. In these studies, it is found that the substitution of PS5/2 by GeS2, that is, increasing x, leads to unequal sharing of the Na+ in these glasses. Thus, in all MGF compositions, phosphorus groups are associated with a disproportionately larger fraction, fNa(P) \u3e 0.5(1 – x), of the Na+ ions while the germanium groups are found to be Na+-deficient relative to the total amount of Na+ present in the glass, that is, fNa(Ge) \u3c 0.5x. From the spectroscopic study of these glasses, a short-range order (SRO) structural model is developed for these glasses and is based on the germanium and phosphorus SRO groups in these glasses as a first step in understanding the unique negative MGFE and non-Arrhenius behavior in the Na+ ion conductivity in these glasses

From the Cover: Assignment of an Essential Role for the Neurospora Frequency Gene in Circadian Entrainment to Temperature Cycles

Circadian systems include slave oscillators and central pacemakers, and the cores of eukaryotic circadian clocks described to date are composed of transcription and translation feedback loops (TTFLs). In the model system Neurospora, normal circadian rhythmicity requires a TTFL in which a White Collar complex (WCC) activates expression of the frequency (frq) gene, and the FRQ protein feeds back to attenuate that activation. To further test the centrality of this TTFL to the circadian mechanism in Neurospora, we used low-amplitude temperature cycles to compare WT and frq-null strains under conditions in which a banding rhythm was elicited. WT cultures were entrained to these temperature cycles. Unlike those normal strains, however, frq-null mutants did not truly entrain to the same cycles. Their peaks and troughs always occurred in the cold and warm periods, respectively, strongly suggesting that the rhythm in Neurospora lacking frq function simply is driven by the temperature cycles. Previous reports suggested that a FRQ-less oscillator (FLO) could be entrained to temperature cycles, rather than being driven, and speculated that the FLO was the underlying circadian-rhythm generator. These inferences appear to derive from the use of a phase reference point affected by both the changing waveform and the phase of the oscillation. Examination of several other phase markers as well as results of additional experimental tests indicate that the FLO is, at best, a slave oscillator to the TTFL, which underlies circadian rhythm generation in Neurospora

1837-06 Supreme Judicial Court Opinions Regarding Fugitives

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Data Assimilation Enhancements to Air Force Weathers Land Information System

The United States Air Force (USAF) has a proud and storied tradition of enabling significant advancements in the area of characterizing and modeling land state information. 557th Weather Wing (557 WW; DoDs Executive Agent for Land Information) provides routine geospatial intelligence information to warfighters, planners, and decision makers at all echelons and services of the U.S. military, government and intelligence community. 557 WW and its predecessors have been home to the DoDs only operational regional and global land data analysis systems since January 1958. As a trusted partner since 2005, Air Force Weather (AFW) has relied on the Hydrological Sciences Laboratory at NASA/GSFC to lead the interagency scientific collaboration known as the Land Information System (LIS). LIS is an advanced software framework for high performance land surface modeling and data assimilation of geospatial intelligence (GEOINT) information

Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium

Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify clonally expanded CD4 + T cells, including CCL5+ cells and T peripheral helper (Tph) cells, which show a prominent transcriptomic signature of recent activation and effector function. CD8 + T cells show higher oligoclonality than CD4 + T cells, with the largest synovial clones enriched in GZMK+ cells. CD8 + T cells with possibly virus-reactive TCRs are distributed across transcriptomic clusters. In the B cell compartment, NR4A1+ activated B cells, and plasma cells are enriched in the synovium and demonstrate substantial clonal expansion. We identify synovial plasma cells that share BCRs with synovial ABC, memory, and activated B cells. Receptor-ligand analysis predicted IFNG and TNFRSF members as mediators of synovial Tph-B cell interactions. Together, these results reveal clonal relationships between functionally distinct lymphocyte populations that infiltrate the synovium of patients with RA