1 research outputs found
Antifungal Activity of Resveratrol Derivatives against <i>Candida</i> Species
<i>trans</i>-Resveratrol
(<b>1a</b>) is a phytoalexin
produced by plants in response to infections by pathogens. Its potential
activity against clinically relevant opportunistic fungal pathogens
has previously been poorly investigated. Evaluated herein are the
candidacidal activities of oligomers (<b>2a</b>, <b>3</b>ā<b>5</b>) of <b>1a</b> purified from <i>Vitis vinifera</i> grape canes and several analogues (<b>1b</b>ā<b>1j</b>) of <b>1a</b> obtained through
semisynthesis using methylation and acetylation. Moreover, <i>trans-</i>Īµ-viniferin (<b>2a</b>), a dimer of <b>1a</b>, was also subjected to methylation (<b>2b</b>) and
acetylation (<b>2c</b>) under nonselective conditions. Neither
the natural oligomers of <b>1a</b> (<b>2a</b>, <b>3</b>ā<b>5</b>) nor the derivatives of <b>2a</b> were
active against <i>Candida albicans</i> SC5314. However,
the dimethoxy resveratrol derivatives <b>1d</b> and <b>1e</b> exhibited antifungal activity against <i>C. albicans</i> with minimum inhibitory concentration (MIC) values of 29ā37
Ī¼g/mL and against 11 other <i>Candida</i> species.
Compound <b>1e</b> inhibited the yeast-to-hyphae morphogenetic
transition of <i>C. albicans</i> at 14 Ī¼g/mL