Funnel plots of study effect size in meta-analysis of the periodontal parameters.

a gingival inflammation; b PPD; c PPD >4 mm; d plaque indices; e CAL. (TIF)</p

PRISMA 2020 flow diagram.

ObjectiveThe present systematic review and meta-analysis aimed to evaluate the periodontal health of systemic sclerosis patients compared with non-systemic sclerosis controls.Materials and methodsOnline databases were searched for eligible studies on February 24, 2023. The primary outcomes of interest in systemic sclerosis patients and controls included the clinical attachment level, periodontal probing depth, recession depth, plaque index, bleeding on probing score, gingival index, number of teeth with periodontitis, prevalence of periodontitis and gingivitis, and extent and severity of periodontitis.ResultsFourteen studies met inclusion criteria and were incorporated in the qualitative and quantitative analysis. In comparison with the controls, systemic sclerosis patients had a higher prevalence of periodontitis (OR = 7.63 (1.74–33.50), p = 0.04, I2 = 69%), including more severe forms of periodontitis (OR = 6.68 (3.39–13.15), p = 0.85, I2 = 0%), as well as higher periodontal probing depth ((0.88 (0.45–1.31), p = 0.02, I2 = 99%)), clinical attachment level (1.22 (0.8–1.64), p = 0.003, I2 = 98%), and plaque presence (0.83 (0.13–1.53), p = 0.03, I2 = 96%). There was no statistically significant difference in gingival inflammation (1.14 (0.07–2.21), p = 0.04, I2 = 98%).ConclusionsThe systematic review and the meta-analysis showed that systemic sclerosis patients suffer from worse periodontal health than non-systemic sclerosis individuals.</div

The study excluded during full-text screening.

A—Inappropriate study design; B—Insufficient data. (DOCX)</p

Characteristics of the studies included in the systematic review.

Characteristics of the studies included in the systematic review.</p

Quality assessment of included studies.

*CD, cannot determine; NA, not applicable; NR, not reported. (DOCX)</p

Electronic databases and search strategy [February 24, 2023].

Electronic databases and search strategy [February 24, 2023].</p

PRISMA 2020 checklist.

ObjectiveThe present systematic review and meta-analysis aimed to evaluate the periodontal health of systemic sclerosis patients compared with non-systemic sclerosis controls.Materials and methodsOnline databases were searched for eligible studies on February 24, 2023. The primary outcomes of interest in systemic sclerosis patients and controls included the clinical attachment level, periodontal probing depth, recession depth, plaque index, bleeding on probing score, gingival index, number of teeth with periodontitis, prevalence of periodontitis and gingivitis, and extent and severity of periodontitis.ResultsFourteen studies met inclusion criteria and were incorporated in the qualitative and quantitative analysis. In comparison with the controls, systemic sclerosis patients had a higher prevalence of periodontitis (OR = 7.63 (1.74–33.50), p = 0.04, I2 = 69%), including more severe forms of periodontitis (OR = 6.68 (3.39–13.15), p = 0.85, I2 = 0%), as well as higher periodontal probing depth ((0.88 (0.45–1.31), p = 0.02, I2 = 99%)), clinical attachment level (1.22 (0.8–1.64), p = 0.003, I2 = 98%), and plaque presence (0.83 (0.13–1.53), p = 0.03, I2 = 96%). There was no statistically significant difference in gingival inflammation (1.14 (0.07–2.21), p = 0.04, I2 = 98%).ConclusionsThe systematic review and the meta-analysis showed that systemic sclerosis patients suffer from worse periodontal health than non-systemic sclerosis individuals.</div

Meta-analysis of periodontal parameters in systemic sclerosis patients and controls.

a prevalence of periodontitis; b prevalence of moderate to severe periodontitis vs mild and no periodontitis; c gingival inflammation; d CAL; e PPD; f sites with PPD>4mm; g plaque indices; h number of missing teeth.</p