Chronic necrotizing pulmonary aspergillosis in an immunocompetent, obese 10-year-old boy

Chronic necrotizing pulmonary aspergillosis is a rare form of pulmonary aspergillosis. It is usually seen in middle-aged or elderly patients with underlying chronic lung disease or mild immunodeficiency, and has been only rarely encountered in children. Clinical presentation is variable and usually involves constitutional symptoms of several months' duration as well as respiratory symptoms. We present a previously well, immunocompetent, obese 10-year-old boy with cough and mild hemoptysis lasting for a couple of days and a round pulmonary infiltrate on chest radiograph. Further diagnostic investigations revealed the histopathological features of chronic necrotizing pulmonary aspergillosis in excised lung tissue, and Aspergillus fumigatus was isolated in lung tissue culture. This is one of the youngest described patients with this semi-invasive form of aspergillosis

Pneumovirus infection and effects on dendritic cells of mice

Respiratory syncytial virus (RSV) is the primary viral pathogen responsible for lower respiratory tract disease in neonates and young children worldwide. By the age of two, virtually all children have been infected with RSV, and approximately 40% of them develop lower respiratory tract infections. In addition to acute morbidity, an association between RSV infection in early childhood and later development of recurrent wheezing and airway hyperresponsiveness (AHR) has been repeatedly demonstrated.In this work we established a method for propagating pneumonia virus of mice (PVM) in a baby hamster kidney-21 (BHK-21) cell line. We also modified the standard plaque assay method and established a reliable and, most importantly, reproducible way to quantitate PVM. In our work we used PVM strain 15 to successfully establish an in vivo animal model for RSV disease in Balb/c and C57/Bl mice. Different susceptibility/resistance patterns to a pathogen exist for different mouse strains. In the case of Balb/c and C57/Bl mice, these patterns are well characterized for several pathogens including Leishmania major and adenovirus type 1. Our comparative study demonstrated clear differences in susceptibility to PVM strain 15 infection between Balb/c and C57/Bl mice; Balb/c mice being more susceptible. In peripheral sites, dendritic cells (DCs) serve as sentinel cells that take up and process antigens. Numerous studies revealed that certain pathogens stimulate changes in DC phenotypic characteristics and thus contribute to functional alterations that lead to inappropriate T cell activation and disease augmentation. To examine effects of PVM on DCs, we infected bone marrow dendritic cells (BM-DCs) derived from both mouse strains with PVM, and evaluated their phenotypic and functional characteristics 24 hours post infection. Under these experimental conditions, PVM infected BM-DCs did not show a significant increase in the expression of costimulatory and major histocompatibility complex class II (MHC II) molecules compared to uninfected controls. Furthermore, there were no changes in the ability of PVM-infected DCs to take up soluble antigen. The production of IL-12p70, the pivotal cytokine in the development of a Th1-type response, by the PVM-infected BM-DCs was not significantly different from uninfected cells. In addition, there was no significant impact of PVM infection on the ability of DCs to induce naïve T cell proliferation

ORGANIC FARMING PRODUCTION AND ROLE OF MARKETING

For the reason of constant need for rising food production which are determinate with a large number of famine all over the world, it was intensively developed technique and technology in agricultural production which based on unnatural synthetic materials, where belong mineral fertilizers, pesticides, factors which stimulate rise, hormones, etc., also which contributed that outputs have large rise. However, uncontrolled process of using agrochemical substances, process of intensive using hard agricultural mechanization, and also process of pollution, resulted that we have problems with environment. Organic farming has developed from that reason as a result on ecological degradation and jeopardizing human population. This paper work tries to show importance of organic farming production, but also look towards importance of marketing in organic farming production of food and way how to sell it on the market

CHEESES WITH ADDITIONS

In this paper work we show data about cheese production in world and in Serbia, different cheese sorts and different cheese addition in contexts of achieving specific season, nutritive and functional characteristics, especially from the aspects of official Statutes about quality and other requirement for milk, milk products, composite milk products and starter culture

ANALYSIS OF PRODUCING MILK AND DEVELOP PERSPECTIVE OF IN THE REPUBLIC OF SERBIA

Research in this paper work tends to show basic characteristic in producing cow and sheep milk in the Republic of Serbia in period 1998 – 2007. Paper work analyzed production cow and sheep milk in regions in Central Serbia and Vojvodina, also paper analyzed changes which held in production during researching period and participation of production cow and sheep milk in the Republic of Serbia, using base index. Paper work try to give theoretical and practical contribution for farmers who are involving directly or indirectly in milk production, to have aims in using adequate measure to develop their cattle-breeding and sheep farming, particularly in milk area

INVESTMENT ECONOMY IN IRRIGATION SYSTEM IN CLIMATIC CONDITIONS IN RASPBERRY REGION OF ARILJE AREA

Тhis work have analysed climatic water balance in Raspberry region of Arilje in vegetative cycle of raspberry, in function of yield fluctuation in natural condition and irrigation water balance regime of soil and economical payable for introduction of irrigation in raspberry production. Introduction of irrigation, raspberry yields can be increased in average 1,8- 3,3 times in relation to yield without irrigation, and investment in mini-irrigation system construction, on surface for just one plant, with water supporting from local watercourse can be pay off for one growing season. Raspberry reacts on irrigation with increasing yield in such a level that it is profitable to invest in mini-irrigation system construction every year again

Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesis

Human T-cell leukaemia virus type-1 (HTLV-1) and bovine leukaemia virus (BLV) infect T- and B-lymphocytes, respectively, provoking a polyclonal expansion that will evolve into an aggressive monoclonal leukaemia in ∼5% of individuals following a protracted latency period. It is generally assumed that early oncogenic changes are largely dependent on virus-encoded products, especially TAX and HBZ, while progression to acute leukaemia/lymphoma involves somatic mutations, yet that both are independent of proviral integration site that has been found to be very variable between tumours. Here, we show that HTLV-1/BLV proviruses are integrated near cancer drivers which they affect either by provirus-dependent transcription termination or as a result of viral antisense RNA-dependent cis-perturbation. The same pattern is observed at polyclonal non-malignant stages, indicating that provirus-dependent host gene perturbation contributes to the initial selection of the multiple clones characterizing the asymptomatic stage, requiring additional alterations in the clone that will evolve into full-blown leukaemia/lymphoma.SCOPUS: ar.jinfo:eu-repo/semantics/publishe