TST and IGRA concordant and discordant results.

<p>TST and IGRA concordant and discordant results.</p

Multivariable logistic regression model for predictors of discordance between the TST and IGRA (TST+/IGRA− compared to TST−/IGRA−) adjusting for gender, ethnicity and repeated TSTs (n = 38).

<p>*BCG repeated refers to more than one BCG vaccine given on separate occasions.</p><p>Multivariable logistic regression model for predictors of discordance between the TST and IGRA (TST+/IGRA− compared to TST−/IGRA−) adjusting for gender, ethnicity and repeated TSTs (n = 38).</p

Univariable logistic regression model for predictors of discordance between the TST and IGRA (TST+/IGRA− compared to TST−/IGRA−) (n = 38).

<p>*defined as the 1^st year of life.</p><p>Univariable logistic regression model for predictors of discordance between the TST and IGRA (TST+/IGRA− compared to TST−/IGRA−) (n = 38).</p

Demographics of Iqaluit residents who accepted screening for LTBI in residential areas of high risk for TB^*.

<p>*More detailed description of the population <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111986#pone.0111986-Alvarez1" target="_blank">[9]</a>.</p><p>**BCG vaccination was recorded only if records indicated that the vaccine was given or not given.</p><p>Demographics of Iqaluit residents who accepted screening for LTBI in residential areas of high risk for TB^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111986#nt101" target="_blank">*</a>}.</p

TAIMA (Stop) TB: The Impact of a Multifaceted TB Awareness and Door-to-Door Campaign in Residential Areas of High Risk for TB in Iqaluit, Nunavut

<div><p>Background</p><p>The incidence rate of active tuberculosis (TB) disease in the Canadian Territory of Nunavut has shown a rising trend over the past 10 years. In 2010 it was 60 times greater than the national incidence rate. The objective of the Taima (translates to “stop” in Inuktitut) TB study was to implement and evaluate a public health campaign to enhance existing TB prevention efforts in Nunavut.</p><p>Methods</p><p>A TB awareness campaign followed by a door-to-door screening campaign was carried out in Iqaluit, Nunavut. The aim of the campaign was to raise awareness about TB, and to provide in-home screening and treatment for people living in residential areas at high risk for TB. Screening was based on geographic location rather than on individual risk factors.</p><p>Results</p><p>During the general awareness campaign an increase in the number of people who requested TB testing at the local public health clinic was observed. However, this increase was not sustained following cessation of the awareness campaign. Targeted TB screening in high risk residential areas in Iqaluit resulted in 224 individuals having TSTs read, and detection of 42 previously unidentified cases of latent TB, (overall yield of 18.8% or number needed to screen = 5.3). These cases of latent TB infection (LTBI) were extra cases that had not been picked up by traditional screening practices (34% relative increase within the community). This resulted in a 33% relative increase in the completion of LTBI treatment within the community. The program directly and indirectly identified 5/17 new cases of active TB disease in Iqaluit during the study period (29.5% of all incident cases).</p><p>Conclusions</p><p>While contact tracing investigations remain a cornerstone of TB prevention, additional awareness, screening, and treatment programs like Taima TB may contribute to the successful control of TB in Aboriginal communities.</p></div

Multiple logistic regression of persons ≥15 years of age with a positive TST (≥10 mm) who had not received treatment in the past (n = 185).

†<p>versus non current smoker.</p

Number of dwellings visited by the Taima TB team during study period (June to November 2011).

<p>Number of dwellings visited by the Taima TB team during study period (June to November 2011).</p

Additional yield of new TST positives obtained during screening in the Taima TB program (location based screening) to the local program (includes all forms of screening) over six month period (June to November 2011).

<p>*received home awareness as part of the Taima TB program, N/A not applicable.</p

Demographics of Taima TB participants who consented to enter study (n = 590).

<p>Demographics of Taima TB participants who consented to enter study (n = 590).</p

The average number of passive LTBI screenings in 4 month periods prior (10 consecutive periods from 2007–2011) during* (1 period from January to April 2011 inclusive) and after the Taima TB general awareness campaign (8 periods from May 2012 to January 2014 inclusive).

<p>The average number of passive LTBI screenings in 4 month periods prior (10 consecutive periods from 2007–2011) during* (1 period from January to April 2011 inclusive) and after the Taima TB general awareness campaign (8 periods from May 2012 to January 2014 inclusive).</p