Is it possible to accurately differentiate neurocardiogenic syncope from epilepsy?

Global cerebral hypoperfusion resulting in syncope, and asynchronous discharge of cerebral neurons leading to seizure, are two major mechanisms of transient loss of consciousness. They both have a lot in common in clinical and historical settings, although with a high prevalence of incorrect diagnosis, even by well-trained staff. The aim of this review was to try to combine data from both a cardiologist’s and a neurologist’s perspective (history taking, special questionnaires, serum prolactin, EEG, CT/MRI, tilt-testing, loop recorders). (Cardiol J 2010; 17, 4: 420-427