6 research outputs found

    Wpływ statyn na zmniejszenie średniej objętości płytek krwi niezależnie od ich działania hipolipemizującego

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    Background: Recent clinical observations have demonstrated that the beneficial effects of statins are not limited to LDL lowering effect. They have also favourable effects on platelet activation, endothelial function, inflammation, and coagulation cascade.Aim: To investigate the effects of statins on mean platelet volume (MPV) which is a simple measure of platelet activation volume in patients who have been prescribed statins. Atorvastatin and rosuvastatin were also compared in respect to effects on MPV.Methods: One hundred and forty five patients were retrospectively included in the study from the outpatient cardiology clinic. Patients who had been given statin treatment were recruited based on the records. Baseline and 4–8 weeks biochemical analysis and haematological measurements and cardiovascular risk factors were recorded.Results: Both statins significantly decreased the MPV. MPV of patients did not show any significant correlation with lipid parameters. Linear regression analysis revealed that there were no statistically significant associations of ∆ MPV with the ∆ LDL-cholesterol (beta coefficient = 0.13; p = 0.24), ∆ DL-cholesterol (beta coefficient = 0.17; p = 0.18) or ∆ triglyceride (beta coefficient = –0.11; p = 0.21) after statin treatment. Both statins had comparable effects on lipid parameters at the end of the one month follow up period.Conclusion: Statins significantly reduce MPV irrespective of cholesterol levels, and atorvastatin and rosuvastatin have comparable effects in this regard.Wstęp: W najnowszych badaniach klinicznych wykazano, że korzystne efekty stosowania statyn nie ograniczają się do zmniejszenia stężenia cholesterolu frakcji LDL. Korzystny wpływ tych leków wynika również z ich oddziaływania na aktywację płytek, czynność śródbłonka, proces zapalenia i kaskadę krzepnięcia.Cel: Celem niniejszej pracy była ocena wpływu statyn na średnią objętość płytek krwi (MPV), która jest prostym wskaźnikiem aktywacji płytek. Porównano ponadto wpływ atorwastatyny i rosuwastatyny na średnią MPV.Metody: Do badania włączono retrospektywnie 145 pacjentów przychodni kardiologicznej. Chorych przyjmujących statyny rekrutowano na podstawie dokumentacji medycznej. Na początku badania i po 4–8 tygodniach przeprowadzono analizy biochemiczne oraz oceniono czynniki ryzyka sercowo-naczyniowego.Wyniki: Obie statyny spowodowały istotnie zmniejszenie MPV. Nie stwierdzono znamiennych korelacji między MPV a parametrami lipidowymi. Na podstawie analizy regresji liniowej wykazano brak statystycznie istotnych zależności między zmianą MPV a zmianą stężeń cholesterolu frakcji LDL (współczynnik beta = 0,13; p = 0,24), cholesterolu frakcji HDL (współczynnik beta = 0,17; p = 0,18) i triglicerydów (współczynnik beta = –0,11; p = 0,21) po leczeniu statynami. Wpływ obu statyn na parametry lipidowe oceniany w momencie zakończenia miesięcznego okresu obserwacji był porównywalny.Wnioski: Statyny istotnie obniżają średnią objętość płytek krwi, niezależnie od stężenia cholesterolu; wpływ atorwastatyny i rosuwastatyny jest pod tym względem podobny

    Evaluation of Cardiovascular Risk Factors in Women with Uterine Leimyoma: Is There a Link with Atherosclerosis?

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    Objective: Both uterine leimyoma (UL) and cardiovascular disease are public health problems affecting women at different age ranges. Smoking, obesity, and hypertension have been shown to be associated with UL in different random studies. However cardiovascular risk factors have not been evaluated systematically in patients with UL. Accordingly, we aimed to evaluate the cardiovascular risk factors and their relation with the presence of UL.Material and Methods: One hundred and eighty nine patients with the pathological diagnosis of UL and one hundred and eighty nine age matched control subjects without UL were retrospectively included in the study from our data base of the pathology and gynecology departments. Controls were patients with intact uteri who had visited the same physicians for a routine checkup that included a pelvic examination and uterine sonogram and without mention of physical findings consistent with UL. The following clinical and demographic parameters were recorded; age, sex, hypertension, diabetes mellitus, and hypercholesterolemia. Current cigarette smoking was defined as active smoking within the past 12 months. Results: Comparison of cardiovascular risk factors between with and without UL revealed that the presence of hypertension (80 (42.3%) vs 53 (28%) p=0.004) diabetes mellitus (33 (17.4%) vs. 16 (8.4%) p=0.009), smoking (31 (16.4%) vs. 11 (5.8%) p=0.001), were significantly higher in patients with UL than in control subjects. The mean-age and presence of hyperlipidemia were comparable between the two groups. Logistic regression analysis revealed an independent and positive association of UL with the presence of hypertension (odds ratio 2.02 CI: 1.25-3.27 p=0.004), diabetes mellitus (odds ratio 2.43 CI: 1.23-4.79 p=0.010), and smoking status (odds ratio 3.46 CI: 1.65-7.22 p=0.001).Conclusion: We have shown that major cardiovascular risk factors namely, hypertension, diabetes mellitus and smoking are significantly and independently associated with UL. Our findings highlight the possible association of UL with atherosclerosis

    Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study

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    The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albino rats. The experimental groups received the following oral treatments daily for 6 days: group I saline control; group II, standard (aspirin) treatment group [150 mg/kg of body weight]; group III, test (compound I) treatment group [100, 150 mg/kg]; group IV, test (compound II) treatment group [100, 150 mg/kg]. The results showed that in the case of the aspirin treated group and compound (I) [150 mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes. Utilizing the same protocol, synthetic compound (I) [100 mg/kg] and (II) [100, 150 mg/kg] exhibited no statistically significant ulcerogenic or cytotoxic properties. A cyclooxygenase (COX) selectivity test indicated the preferential inhibition of COX-I and COX-II enzymes by compounds (I) and (II). This study therefore indicates that these synthetic compounds may possess reduced ulcerogenic potential and could be a functional substitute to aspirin
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