Optimization of Support Structures for Offshore Wind Turbines Using Genetic Algorithm with Domain-Trimming

The powerful genetic algorithm optimization technique is augmented with an innovative “domain-trimming” modification. The resulting adaptive, high-performance technique is called Genetic Algorithm with Domain-Trimming (GADT). As a proof of concept, the GADT is applied to a widely used benchmark problem. The 10-dimensional truss optimization benchmark problem has well documented global and local minima. The GADT is shown to outperform several published solutions. Subsequently, the GADT is deployed onto three-dimensional structural design optimization for offshore wind turbine supporting structures. The design problem involves complex least-weight topology as well as member size optimizations. The GADT is applied to two popular design alternatives: tripod and quadropod jackets. The two versions of the optimization problem are nonlinearly constrained where the objective function is the material weight of the supporting truss. The considered design variables are the truss members end node coordinates, as well as the cross-sectional areas of the truss members, whereas the constraints are the maximum stresses in members and the maximum displacements of the nodes. These constraints are managed via dynamically modified, nonstationary penalty functions. The structures are subject to gravity, wind, wave, and earthquake loading conditions. The results show that the GADT method is superior in finding best discovered optimal solutions

Knowledge of Cancer Among Syrians: A Cross-Sectional Study

Background:  The worldwide burden of cancer continues to rise, mainly due to global demographic changes and an increase in cancer-causing habits, such as smoking, epically in low-income countries. The Syrian National Cancer Registry (SNCR)estimates that 17,599 new cancer cases were diagnosed before the start of the war in 2011. According to statistics from the Al Bairouni 2020 hospital-based registry, which includes data on more than 60% of Syrian cancer patients, the number of cancer diagnoses has been rising in Syria. There is no research conducted in Syria to determine people’s knowledge about cancer and risk factors, symptoms, and signs. This research aims to determine how well-informed Syrians were on the following topics:(i) the age-related risk and prevalence of cancer; (ii) cancer signs and symptoms; and (iii) cancer risk factors. In addition, determining how well-informed different demographic categories.   Method: This is a cross-sectional study which was conducted in Syria. Participants who were eligible to participate in the study who were residents of Syria irrespective their age or gender. The instrument of survey was a structured questionnaire the content of which was adapted from the validated cancer awareness measure (CAM) the cam was translated to Arabic and a scoring system was applied to the questionnaire. The questionnaire was distributed via several social media platforms.   Results: A total of 1463 participants completed the questionnaire. There were 768 respondents (52.5%) said that there is no relation between age and cancer. Almost all the participants (85.6%) thought that the breast cancer is the most common cancer among women, while around half of the participants (55.1%) reported that the prostate cancer was the most common cancer among males. The most frequently reported cancer symptom was unexplained weight loss (73.2%), followed by unexplained swelling/lump (66.5%). The level of knowledge about cancer signs/symptoms among the participants were good in 623 (42.6%), fair in 594 (40.6%), and poor in 246 (16.8%). The most commonly recognized risks of cancer were smoking (83.5%).   Conclusion: According to this research, taking into consideration the war and the bad economic situation that Syria is facing, Syrians’ knowledge towards cancer is acceptable. However, it is not meeting the ideal expectations. More research should be held to dig deeper into this issue

NUMERICAL INVESTIGATION OF ABOVE-SEA GAS DISPERSION AND EXPECTED EXPLOSION OVERPRESSURE ON THE OFFSHORE PLATFORM UNDER VARYING SEA AND WEATHER CONDITIONS

Above sea gas dispersion resulting from subsea release could cause explosion risk to a nearby offshore platform. Past researchers performed a CFD-based assessment of above sea gas dispersion under the varying sea and environment conditions, but the resulting expected overpressure consequences due to the potential ignition of dispersing flammable on an offshore platform under such varying conditions were not investigated. Overpressure estimates under varying sea and weather parameters could support the practitioners in determining the most critical conditions that correspond to the worst consequences on the offshore platform thus, the research could contribute to process safety. Therefore, in this study, above sea gas dispersion under varying wind speeds in range 2-6 m/s and sea surface release rates of 390 kg/s and 872 kg/s were performed using a Fire Dynamics Simulator (FDS), and expected overpressure consequences in each case are estimated based on the flammable concentration distribution on the platform. It was found that low wind speed and less release rate do not pose a danger to the platform. However, compared to the low wind-low release rate, 35% greater platform area was covered by flammable gas cloud at a high wind speed of 6 m/s and a high release rate of 872 kg/s. This could cause overpressure of 70 kPa in 7.5% of the platform region, which is identified as the most dangerous release rate and wind speed condition. It is suggested that the operators on the offshore platform take special care in high wind and release rate scenarios to avoid flammable cloud accumulation and resulting overpressure consequences

Numerical investigation on the effect of channelled and unchannelled screens on smoke contamination in atriums upper balconies with open upstand

Channel screens are used to restrict the smoke from spreading laterally under the first balcony. Effect of channel screens on smoke contamination in atrium upper balconies with the presence of balcony open upstand and 1m deep down stand at the fire compartment is investigated in this paper. Fire dynamic simulator (FDS6) which is a computational fluid dynamic (CFD) software was utilized to conduct the simulation. A comparison between the results of smoke contamination with the presence and omission of channeling screens showed that the height of smoke contamination in atrium upper balconies increased by 90% in case of no channel screens at the fire compartment are installed. A new correlation obtained from this work is able to predict the height of smoke contamination in atrium upper balconies with the presence of 1m deep down stand, balcony open upstand and no channel screens

Knowledge of Cholera Among Syrians: A Cross-Sectional Study

Background: Cholera is a communicable acute bacterial infection caused by a gram-negative bacterium that is Vibrio Cholera. Worldwide, is estimated that an incidence of 1.3–4.0 millions of cholera infection, leading to 21,000–143,000 deaths annually. Prevention of cholera require a proactive approach rather than reactive, as it`s identified to be the best strategy to decrease the cholera spreading risk in given population or community. Recently WHO warned that, the cholera spreading risk in Syria is very high, which linked to drinking of untreated water and food contamination.   Aim: we conducted this study with aiming to assess the level of knowledge, attitude and practice regarding risks of cholera infection, preventive measures and preparedness among community in Syria. Consequently, recommending suitable measures based on study results.   Methods: An online cross-sectional study was conducted in Syria to assess knowledge, attitude, and practice regarding cholera and cholera vaccine among general population in Syria. The inclusion criteria for participation were Syrian nationality aged 18 or more, male or female, from all governorates of Syria, never have cholera previously, and were willing to participate. The questionnaire was consisting of four sections. The first section was about sociodemographic data. The second section evaluated respondents' self-reported knowledge on cholera and divided into two parts (2a: Knowledge on cholera, its prevention and treatment. 2b Knowledge on cholera vaccine). The third section evaluated respondents’ self-reported practice relating to cholera and its vaccine, this section divided into two parts (3a: Practice relating cholera and its treatment/management. 3b: Practice relating cholera vaccine. The fourth section inquired respondents’ attitude toward cholera and cholera vaccine. 52.9% thought that cholera outbreaks happen in summer seasons.   Results: Among 1563 Syrian national participants, (n=982, 62.8%) were females, and (n=581, 37.2%) males. 60.9% of respondents did not recognize the cholera in the first place. Passing watery stool was the most recognized symptom of cholera with 50.3%, severe dehydration with 31.1%, and repeated vomiting with 10.3%. Lack of safe drinking water was recognized as the most common cause for cholera. Most respondents (54.1%) have chosen IV saline as the treatment of choice for cholera. 85.3% of respondents are with providing health care to the infectants in health centers.   Conclusion: According to our findings, there is insufficient understanding of the cholera symptoms and risk factors. The need for better understanding of such common outbreaks is essential to counter them. Consequently, there is a greater need to increase cholera awareness and education programs on the disease's signs and symptoms and its risk factors. &nbsp

Knowledge of Colorectal Cancer Among Syrians: A Cross-Sectional Study

  Background: The incidence of colorectal cancer is the second highest among women and the third highest among males. Screening for the disease has resulted in a significant decrease in both the prevalence and death rate of colorectal cancer (CRC) during the last two decades. Research has indicated that people unaware of the dangers of colorectal cancer may not participate in diagnostic procedures, which delays detection and reduces the likelihood of survival. Aim: This cross-sectional research seeks to examine the level of knowledge of CRC risk factors in Syria and the variables correlated with a greater level of awareness. Methods: An online cross-sectional study was conducted from 1 to 25 August 2022 to assess the Syrians' degree of awareness of Colorectal Cancer risk factors in Syria and the characteristics associated with a high level of understanding. The survey is based on another study, and the sample inclusion criteria of study participants were Syrian nationals aged 18 or older from all Syrian governorates. The questionnaire included 35 questions divided into 3 sections, sociodemographic variables such as (age, sex, marital status, educational level, occupation…etc.), evaluation of participant knowledge of colorectal cancer risk factors such as (alcohol consumption, Red meat consumption, lack of fiber in the diet, obesity, and old age), and symptoms such as (blood in stool, abdominal pain, constipation, change in defecation habits, general tiredness, unexplained weight loss). Results: Among 702 Syrian national participants, (n=430, 61.3%) were females, and (n=272, 38.7%) males. Only (n=67, 9.5%) participants have a chronic disease. Most participants have shown good knowledge of colorectal cancer symptoms (n=301, 42.9%), and (n=297, 42.3%) participants have shown moderate knowledge of colorectal cancer symptoms. Only (n=123, 17.6%) participants have shown a good understanding of colorectal cancer risk factors, whereas (n=293, 41.7%) have demonstrated poor knowledge. Educational level was related to greater knowledge of colorectal cancer risk factors (P-value 0.05). No correlation was found between other variables and a good awareness of colorectal cancer symptoms and risk factors (P-value > 0.05). Ph.D. degree of educational level (OR = 15.41, 95% CI: 1.211–196.16; P-value<0.05) was associated with good awareness of colorectal cancer symptoms and Widowers' marital status (OR = 7.351, 95% CI: 1.22–44.285; P-value<0.05) was associated with good awareness of colorectal cancer risk factors. Most participants were somewhat confident in their ability to recognize colorectal cancer symptoms (43.60%), whereas just 4.60 % of people were highly confident in their ability to recognize them. Only (24.10%) The participants were not confident in identifying colorectal cancer symptoms. Conclusion: According to our findings, there is insufficient understanding of the colorectal cancer symptoms and risk factors that contribute to the disease's development in patients and its detection in its late stages. Consequently, there is a greater need to increase colorectal cancer awareness and education programs on the disease's signs and symptoms and its risk factors. It may be possible to minimize the frequency of advanced cases of colorectal cancer by increasing the number of screening programs for colorectal cancer in Syria. &nbsp

Cytogenetics and Consequences of Polyploidization on Different Biotic-Abiotic Stress Tolerance and the Potential Mechanisms Involved

The application of polyploidy in sustainable agriculture has already brought much appreciation among researchers. Polyploidy may occur naturally or can be induced in the laboratory using chemical or gaseous agents and results in complete chromosome nondisjunction. This comprehensive review described the potential of polyploidization on plants, especially its role in crop improvement for enhanced production and host-plant resistance development against pests and diseases. An in-depth investigation on techniques used in the induction of polyploidy, cytogenetic evaluation methods of different ploidy levels, application, and current research trends is also presented. Ongoing research has mainly aimed to bring the recurrence in polyploidy, which is usually detected by flow cytometry, chromosome counting, and cytogenetic techniques such as fluorescent in situ hybridization (FISH) and genomic in situ hybridization (GISH). Polyploidy can bring about positive consequences in the growth and yield attributes of crops, making them more tolerant to abiotic and biotic stresses. However, the unexpected change in chromosome set and lack of knowledge on the mechanism of stress alleviation is hindering the application of polyploidy on a large scale. Moreover, a lack of cost-benefit analysis and knowledge gaps on the socio-economic implication are predominant. Further research on polyploidy coupling with modern genomic technologies will help to bring real-world market prospects in the era of changing climate. This review on polyploidy provides a solid foundation to do next-generation research on crop improvement

Unraveling the tripartite interaction of volatile compounds of Streptomyces rochei with grain mold pathogens infecting sorghum

Sorghum is a major grain crop used in traditional meals and health drinks, and as an efficient fuel. However, its productivity, value, germination, and usability are affected by grain mold, which is a severe problem in sorghum production systems, which reduces the yield of harvested grains for consumer use. The organic approach to the management of the disease is essential and will increase consumer demand. Bioactive molecules like mVOC (volatile organic compound) identification are used to unravel the molecules responsible for antifungal activity. The Streptomyces rochei strain (ASH) has been reported to be a potential antagonist to many pathogens, with high levels of VOCs. The present study aimed to study the inhibitory effect of S. rochei on sorghum grain mold pathogens using a dual culture technique and via the production of microbial volatile organic compounds (mVOCs). mVOCs inhibited the mycelial growth of Fusarium moniliforme by 63.75 and Curvularia lunata by 68.52%. mVOCs suppressed mycelial growth and inhibited the production of spores by altering the structure of mycelia in tripartite plate assay. About 45 mVOCs were profiled when Streptomyces rochei interacted with these two pathogens. In the present study, several compounds were upregulated or downregulated by S. rochei, including 2-methyl-1-butanol, methanoazulene, and cedrene. S. rochei emitted novel terpenoid compounds with peak areas, such as myrcene (1.14%), cymene (6.41%), and c-terpinene (7.32%) upon interaction with F. moniliforme and C. lunata. The peak area of some of the compounds, including furan 2-methyl (0.70%), benzene (1.84%), 1-butanol, 2-methyl-(8.25%), and myrcene (1.12)%, was increased during tripartite interaction with F. moniliforme and C. lunata, which resulted in furan 2-methyl (6.60%), benzene (4.43%), butanol, 2-methyl (18.67%), and myrcene (1.14%). These metabolites were implicated in the sesquiterpenoid and alkane biosynthetic pathways and the oxalic acid degradation pathway. The present study shows how S. rochei exhibits hyperparasitism, competition, and antibiosis via mVOCs. In addition to their antimicrobial functions, these metabolites could also enhance plant growth.Peer reviewe

Impact of antimicrobial stewardship programme on hospitalized patients at the intensive care unit: a prospective audit and feedback study

AIMS: Inappropriate use of antibiotics is one of the most important factors contributing to the emergence of drug resistant pathogens. The purpose of this study was to measure the clinical impact of antimicrobial stewardship programme (ASP) interventions on hospitalized patients at the Intensive care unit at Palestinian Medical Complex. METHODS: A prospective audit with intervention and feedback by ASP team within 48-72 h of antibiotic administration began in September 2015. Four months of pre-ASP data were compared with 4 months of post-ASP data. Data collected included clinical and demographic data; use of antimicrobials measured by defined daily doses, duration of therapy, length of stay, readmission and all-cause mortality. RESULTS: Overall, 176 interventions were made the ASP team with an average acceptance rate of 78.4%. The most accepted interventions were dose optimization (87.0%) followed by de-escalation based on culture results with an acceptance rate of 84.4%. ASP interventions significantly reduces antimicrobial use by 24.3% (87.3 defined daily doses/100 beds vs. 66.1 defined daily doses/100 beds P < 0.001). The median (interquartile range) of length of stay was significantly reduced post ASP [11 (3-21) vs. 7 (4-19) days; P < 0.01]. Also, the median (interquartile range) of duration of therapy was significantly reduced post-ASP [8 (5-12) days vs. 5 (3-9); P = 0.01]. There was no significant difference in overall 30-day mortality or readmission between the pre-ASP and post-ASP groups (26.9% vs. 23.9%; P = 0.1) and (26.1% vs. 24.6%; P = 0.54) respectively. CONCLUSIONS: Our prospective audit and feedback programme was associated with positive impact on antimicrobial use, duration of therapy and length of stay