Efek Daun Sirih Merah (Piper Crocatum) Terhadap Kadar Gula Darah Dan Gambaran Morfologi Endokrin Pankreas Tikus Wistar (Rattus Norvegicus)

: Leaves of 'sirih merah‘ (Piper Crocatum) contain compounds such as flavonoid, alkaloid and tannin, wich are capable of lowering blood sugar levels. This study aimed to investigate the effects of the administration of ‘sirih merah' broth on blood sugar levels and histopathological features of pancreatic endocrine. This was a laboratory experimental study which was conducted for five month using 12 wistar rats as objects. The rats were divided into four groups: Group A (negative control), which received no treatment; group B, which were given the broth of ‘sirih merah' at 2,4 ml; Group C, which were given sugar solution at 2,4 ml; and Group D, which were given the broth (1,2 ml) and sugar solution (1,2 ml). The results revealed that the levels of blood sugar decreased in rats in Groups B and D but increased in Group C. When compared with rats in Group A, the size and the number of Langerhans islets increased in Group C (more than twice). On the contrary, the number of Langerhans islets in Group D was relatively similar with that of Group A. Conclusion: The administration of the broth of ‘sirih merah' leaves is able to lower blood sugar levels and to cause hyperplasia of pancreatic Langerhans islets