Prediction of sleep quality and insomnia severity by psychological disorders and acute stress among earthquake survivors in Sarpol-e Zahab, Iran, 2017

Background: Psychological and health outcomes of natural disasters such as earthquakes affect survivors and health services for a long time. In the present study, posttraumatic stress disorders (PTSD), symptoms of psychopathology, sleep quality, and insomnia disorder were investigated among survivors of earthquake occurred at the Western Iran on November 12, 2017. Materials and Methods: This study was conducted on 1031 adult participants from rural and urban areas of Sarpol-e Zahab, a city in Kermanshah Province (Western Iran), who suffered from mental health problems due to the earthquake, a magnitude-7.3 quake, occurred in the Western Iran in 2017. Participants completed the Symptom Checklist 90, Insomnia Severity Index, Pittsburgh Sleep Quality Index, and Self-Rating Scale for PTSD. Data were analyzed using Pearson correlation and multivariate regression analysis by Statistical Package for Social Sciences Software (Version 21). Results: A positive correlation was observed between insomnia severity and all psychopathological symptoms. There was a positive correlation between sleep quality and somatization, obsessive compulsive disorder, depression, and psychoticism. In addition, acute stress was positively correlated with insomnia severity and sleep quality. Conclusion: According to the results of the present study, it is recommended that psychological disorders in earthquake victims be considered to enhance their sleep quality

The effect of Reference memory on the number of astrocytes in different subfield of Rat’s hippocampus

Background & Objective: In addition to pyramidal neurons and interneurons, the hippocampus contains Astrocytes that play important roles in regulating ion flux currents, energy production, neurotransmitter release and memory. Learning needs some instrument for information storage and information maintenances mechanisms resemble to memory. The aim of this study was determination of spatial memory effect on the number of astrocytes in rat’s hippocampus. Materials & Methods: In this experimental study, with usage of Morris Water Maze and Reference memory technique, we used 10 male albino wistar rats. 5 rats were in control group and 5 rats in Reference memory group. After histological preparation, the slides were stained with PTAH staining for showing the Astrocytes. Results: The findings of this study showed significant difference in astrocytes number in CA1, CA2 and CA3 area of hippocampus between control and reference memory group. The mean and SD of astrocytes in CA1, CA2 and CA3 of reference memory group were 118.57±25.29, 58.91±23.59 and 116.6±31.14, that they are more than control group with 49±17.29 in CA1, 48.8±25.21 in CA2 and 41.95±11.22 in CA3. Conclusion: We concluded that the number of astrocytes increased due to spatial learning (e.g. reference memory method)

Effect of physical exercise on muscle strength, static and dynamic balance and resiliency in women with multiple sclerosis

Exercise is an essential component in the management of multiple sclerosis (MS). The purpose of this study was to evaluate the effect of a combined aerobic and resistance training programme on muscular strength, static and dynamic balance and resiliency of women with MS. Twenty participants aged 20-40 years with an expanded disability status Scale Level of 2 to 5 were selected. Participants wererandomly divided into two groups: Experimental Group (age=36.1±2.2 years) and Control Group (age=34.3±5.4 years). The experimental group performed combination training that included aerobic and resistance exercises for eight weeks, three times a week, with an intensity of 40% to 55% heart rate reserve. The strength of knee flexor and extensor muscles, dynamic and static balance and resiliency level using Connor-Davidson were assessed. There were significant (p≤0.05) changes in all measured parameters for the Intervention Group, no significant (p>0.05) changes were found from pre- to post-test in the Control Group. Eight weeks of combined training improved significantly (p≤0.05) for muscle strength, balance and resiliency level in the Experimental Group when compared to the Control Group. Combined training may inevitably aid daily functioning and mental health in individuals with MS. Keywords: Concurrent training; Endurance training; Multiple sclerosis; Physical exercise

Astrocytes in Molecular Layer of Cerebellum after Spatial Learning

Introduction: Previous studies have suggested that the cerebellum is a primary site of motor learning. The cerebellar cortex has a particular glial architecture with large astroglial cells. In addition, more recent works have revealed that astrocytes play a more active role in neuronal activity. The aim of this study was to evaluate the number of astrocytes in the molecular layer of rat's cerebellum after spatial learning. 21 male albino wistar rats were used in this study. Reference and working memory methods of Morris Water Maze (MWM) were used. Following behavioral testing, animals were decapitated under diethyl ether anesthesia. Brains were removed and fixed for 2 weeks for histological assessment. Finally, 7 μm thick coronal slices were cut and stained with PTAH staining for showing the astrocytes. Results: Our results showed a significant difference in the number of astrocytes between the control, reference and working memory groups. On the other hand, the number of astrocytes in the working memory group was more than the other groups. There was no difference in density of astrocytes between the lateral and medial parts of the cerebellum in any group. It seems that the distribution of astrocytes in the lateral and medial parts of cerebellum is similar. Discussion: We concluded that spatial learning such as reference or working memory methods, can increase the number of astrocytes in the cerebellum and this increase is similar in the cerebellar cortex. Methods

Astrocytes in Molecular Layer of Cerebellum after Spatial Learning

　Introduction: Previous studies have suggested that the cerebellum is a primary site of motor learning. The cerebellar cortex has a particular glial architecture with large astroglial cells. In addition, more recent works have revealed that astrocytes play a more active role in neuronal activity. The aim of this study was to evaluate the number of astrocytes in the molecular layer of rat's cerebellum after spatial learning. Methods: 21 male albino wistar rats were used in this study. Reference and working memory methods of Morris Water Maze (MWM) were used. Following behavioral testing, animals were decapitated under diethyl ether anesthesia. Brains were removed and fixed for 2 weeks for histological assessment. Finally, 7 μm thick coronal slices were cut and stained with PTAH staining for showing the astrocytes. Results: Our results showed a significant difference in the number of astrocytes between the control, reference and working memory groups. On the other hand, the number of astrocytes in the working memory group was more than the other groups. There was no difference in density of astrocytes between the lateral and medial parts of the cerebellum in any group. It seems that the distribution of astrocytes in the lateral and medial parts of cerebellum is similar. Discussion: We concluded that spatial learning such as reference or working memory methods, can increase the number of astrocytes in the cerebellum and this increase is similar in the cerebellar cortex