The educational ideas of Mahatma Gandhi

An analysis of Gandhi’s ideology and educational aims and processes, emphasising the role of the mother. The central feature of education as envisaged by Gandhi is that it should be through a productive craft

Cytokine and hormonal regulation of bone marrow immune cell Wnt10b expression

This study is funded by National Center for Complementary and Integrative Health (https://nccih.nih.gov/), U.S National Institutes of Health (Grant Code: 1R01AT007695-01) awarded to LRM and NP and by National Institute of Diabetes and Digestive and Kidney Diseases (www.niddk.nih.gov/), U.S National Institutes of Health (Grant code: R01DK101050) awarded to LRM and NP. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Lactobacillus reuteri 6475 increases bone density in intact females only under an inflammatory setting

Peer reviewedPublisher PD

Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice

We thank Jenny Auchtung, James Collins, and Laura Schaefer for technical support. James Collins, and Laura Schaefer provided expertise in tissue collection for the animal experiments, and Jenny Auchtung provided expertise in bioinformatics and microbial community analysis. This work was supported by NIH grant NCCIH R01AT007695-05 to N.P., L.M., and R.A.B., as well as seed funding from Baylor College of Medicine to R.A.B. The authors report that they have no competing interests.Peer reviewedPublisher PD

Temporal and regional intestinal changes in permeability, tight junction, and cytokine gene expression following ovariectomy-induced estrogen deficiency

The work presented within this study was funded in part by NCCIH (R01AT007695) and NIDDK (R01DK101050Peer reviewedPublisher PD

Tumor Necrosis Factor-α Signaling in Macrophages

Tumor necrosis factor-α (TNFα) was cloned over 2 decades ago and its identification in part led to the discovery of a super family of tumor necrosis factors (TNFs) and their receptors. TNFα signals through two transmembrane receptors, TNFR1 and TNFR2, and regulates a number of critical cell functions including cell proliferation, survival, differentiation, and apoptosis. Macrophages are the major producers of TNFα and interestingly are also highly responsive to TNFα. Aberrant TNFα production and TNF receptor signaling have been associated with the pathogenesis of several diseases, including rheumatoid arthritis, Crohn’s disease, atherosclerosis, psoriasis, sepsis, diabetes, and obesity. TNFα has been shown to play a pivotal role in orchestrating the cytokine cascade in many inflammatory diseases and because of this role as a “master-regulator” of inflammatory cytokine production, it has been proposed as a therapeutic target for a number of diseases. Indeed anti-TNFα drugs are now licensed for treating certain inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. In this review we discuss the discovery of TNFα and its actions especially in regulating macrophage biology. Given its importance in several human diseases, we also briefly discuss the role of anti-TNFα therapeutics in the treatment of inflammatory diseases

Does mothers' perception of wheezing affect the nutritional status of wheezers?

Abstract This study was conducted to find out mothers' perception of factors associated with wheezing and its effect on the nutritional status of children with recurrent wheezing. 'Cold food' which includes all refrigerated food, curd and certain types of green leafy vegetables were perceived to be associated with wheezing by 70% of mothers. These items were not included in the diet of children with wheezing. However there was no significant difference in the nutritional intake or nutritional status of children with and without wheezing perhaps due to infrequent inclusion of the same even in the normal children's diet