Model selection for DCE‐T1 studies in glioblastoma

Dynamic contrast enhanced T 1 ‐weighted MRI using the contrast agent gadopentetate dimeglumine (Gd‐DTPA) was performed on 10 patients with glioblastoma. Nested models with as many as three parameters were used to estimate plasma volume or plasma volume and forward vascular transfer constant ( K trans ) and the reverse vascular transfer constant ( k ep ). These constituted models 1, 2, and 3, respectively. Model 1 predominated in normal nonleaky brain tissue, showing little or no leakage of contrast agent. Model 3 predominated in regions associated with aggressive portions of the tumor, and model 2 bordered model 3 regions, showing leakage at reduced rates. In the patient sample, v p was about four times that of white matter in the enhancing part of the tumor. K trans varied by a factor of 10 between the model 2 (1.9 ↔ 10 −3 min −1 ) and model 3 regions (1.9 ↔ 10 −2 min −1 ). The mean calculated interstitial space (model 3) was 5.5%. In model 3 regions, excellent curve fits were obtained to summarize concentration‐time data (mean R 2 = 0.99). We conclude that the three parameters of the standard model are sufficient to fit dynamic contrast enhanced T 1 data in glioblastoma under the conditions of the experiment. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91323/1/23211_ftp.pd

Case Report-Melorheostosis: Follow-up of a case Compounded with carcinoma prostate

A case of melorheostosis, a relatively uncommon congenital condensing bone disease, developed adenocarcinoma of prostate - a relatively slow-growing tumour usually amenable to treatment with good prognosis. The malignancy in this case disseminated unusually fast spelling out the unfavourable prognosis. This patient also had a fracture neck of the femur which unexpected healed very early. We believe that these observations support the notion of the congenital local hypervascularity theory in the aetiology of the disease

Case Report-Melorheostosis: Follow-up of a case Compounded with carcinoma prostate

A case of melorheostosis, a relatively uncommon congenital condensing bone disease, developed adenocarcinoma of prostate - a relatively slow-growing tumour usually amenable to treatment with good prognosis. The malignancy in this case disseminated unusually fast spelling out the unfavourable prognosis. This patient also had a fracture neck of the femur which unexpected healed very early. We believe that these observations support the notion of the congenital local hypervascularity theory in the aetiology of the disease

Sigmoid Kidney Associated with Double Urethra

An unusual case of crossed renal ectopia (sigmoid kidney) in an adult, compounded with double urethra, is being presented for its rarity and mode of presentation

MRI Pre- and Post-Embolization Enhancement Patterns Predict Surgical Outcomes in Intracranial Meningiomas

PURPOSE: To evaluate the effects of preoperative embolization on overall surgical outcomes after meningioma resection and determine whether pre- and postembolization tumor enhancement patterns on magnetic resonance imaging (MRI) scans can be used to assess the efficacy of embolization. METHODS: We developed a prospective database of all patients who underwent surgical resection with or without preoperative embolization for extra-axial intracranial meningiomas from 2004 to 2010. Using specialized computer software, the total volume of enhancement was calculated in pre- and postembolization MRI scans to quantify the percentage of embolization, which was described as the embolization fraction (EF). RESULTS: A total of 89 patients underwent surgical resection. Fifty two patients underwent embolization prior to surgery. Tumor location significantly correlated with the decision to embolize preoperatively. Adequate embolization was achieved in 58% of patients. Forty four patients (84.6%) had a postsurgical Karnofsky performance score (KPS) of 80 or above, while 46 patients (88.4%) had a postsurgical Glascow Outcome Score (GOS) of 4 or 5. The mean EF was 25.03% with a median of 18.72%. A greater extent of embolization as quantified by EF led to decreased intraoperative blood loss (r = -.319, P = .022) and better postsurgical outcomes as defined by KPS (r = .279, P = .044). CONCLUSIONS: Pre- and postembolization tumor enhancement patterns on magnetic resonance imaging defined as EF correlate with improved surgical facilitation and postoperative functional outcomes in the management of intracranial meningioma