Deformation in the hinge region of a chevron fold, Valley and Ridge Province, central Pennsylvania

The hinge region of an asymmetrical chevron fold in sandstone, taken from the Tuscarora Formation of central Pennsylvania, U.S.A., was studied in detail in an attempt to account for the strain that produced the fold shape. The fold hinge consists of a medium-grained quartz arenite and was deformed predominantly by brittle fracturing and minor amounts of pressure solution and intracrystalline strain. These fractures include: (1) faults, either minor offsets or major limb thrusts, (2) solitary well-healed quartz veins and (3) fibrous quartz veins which are the result of repeated fracturing and healing of grains. The fractures formed during folding as they are observed to cross-cut the authigenic cement. Deformation lamellae and in a few cases, pressure solution, occurred contemporaneously with folding. The fibrous veins appear to have formed as a result of stretching of one limb: they cross-cut all other structures. Based upon the spatial relationships between the deformation features, we believe that a neutral surface was present during folding, separating zones of compression and extension along the inner and outer arcs, respectively. Using the strain data from the major faults, the fold can be restored back to an interlimb angle of 157[deg]; however, the extension required for such an angle along the outer arc is much more than was actually measured. This disparity between observed and required deformation suggests that the rest of the folding strain may be attributed to minor faulting, isolated severe pressure solution and to slight grain movements; we were not able to recognize the latter. We propose that a single episode of deformation produced the chevron fold causing the brittle deformation after the sandstone had been lithified. This brittle deformation was accomplished by faulting together with the translation of individual sandstone blocks which do not contain significant internal deformation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26361/1/0000448.pd

Deformation in the nose region of a sandstone-chevron fold, valley and ridge province, central Penns

Master of ScienceGeologyUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/114722/1/39015048153889.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/114722/2/39015048153889.pd

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas

Somatic mutations in the IDH1 gene encoding cytosolic NADP+-dependent isocitrate dehydrogenase have been shown in the majority of astrocytomas, oligodendrogliomas and oligoastrocytomas of WHO grades II and III. IDH2 encoding mitochondrial NADP+-dependent isocitrate dehydrogenase is also mutated in these tumors, albeit at much lower frequencies. Preliminary data suggest an importance of IDH1 mutation for prognosis showing that patients with anaplastic astrocytomas, oligodendrogliomas and oligoastrocytomas harboring IDH1 mutations seem to fare much better than patients without this mutation in their tumors. To determine mutation types and their frequencies, we examined 1,010 diffuse gliomas. We detected 716 IDH1 mutations and 31 IDH2 mutations. We found 165 IDH1 (72.7%) and 2 IDH2 mutations (0.9%) in 227 diffuse astrocytomas WHO grade II, 146 IDH1 (64.0%) and 2 IDH2 mutations (0.9%) in 228 anaplastic astrocytomas WHO grade III, 105 IDH1 (82.0%) and 6 IDH2 mutations (4.7%) in 128 oligodendrogliomas WHO grade II, 121 IDH1 (69.5%) and 9 IDH2 mutations (5.2%) in 174 anaplastic oligodendrogliomas WHO grade III, 62 IDH1 (81.6%) and 1 IDH2 mutations (1.3%) in 76 oligoastrocytomas WHO grade II and 117 IDH1 (66.1%) and 11 IDH2 mutations (6.2%) in 177 anaplastic oligoastrocytomas WHO grade III. We report on an inverse association of IDH1 and IDH2 mutations in these gliomas and a non-random distribution of the mutation types within the tumor entities. IDH1 mutations of the R132C type are strongly associated with astrocytoma, while IDH2 mutations predominantly occur in oligodendroglial tumors. In addition, patients with anaplastic glioma harboring IDH1 mutations were on average 6 years younger than those without these alterations

Molecular genetic approaches to the analysis of human ophthalmic disease

In this review of the recent literature, the contribution that the new techniques of molecular genetics has made in the analysis and diagnosis of human ophthalmic conditions is presented and discussed. Among the disorders reviewed are X-linked retinitis pigmentosa, Norrie's disease, gyrate atrophy and retinoblastoma, and there are also sections on crystallins and visual pigments