11 research outputs found
Nuclear data evaluation of long-lived fission products: Microscopic vs. phenomenological optical potentials
Neutron-nucleus cross sections calculated by macroscopic potentials are compared with a microscopic one to study the performance for long-lived fission products. The macroscopic potentials show a good agreement with the microscopic one at higher energies, where neutron experimental data are scarce. Besides it, analyses of differential elastic cross sections at low energies also suggest that the macroscopic potentials are still effective and applicable enough for the long-lived fission products
Nuclear data evaluation of long-lived fission products: Microscopic vs. phenomenological optical potentials
Neutron-nucleus cross sections calculated by macroscopic potentials are compared with a microscopic one to study the performance for long-lived fission products. The macroscopic potentials show a good agreement with the microscopic one at higher energies, where neutron experimental data are scarce. Besides it, analyses of differential elastic cross sections at low energies also suggest that the macroscopic potentials are still effective and applicable enough for the long-lived fission products
Two Approaches toward the Formal Total Synthesis of Oseltamivir Phosphate (Tamiflu): Catalytic Enantioselective Three-Component Reaction Strategy and l‑Glutamic Acid Strategy
Two
independent formal total syntheses of oseltamivir phosphate
were successfully achieved: the first utilized a copper-catalyzed
asymmetric three-component reaction strategy, and the second utilized l-glutamic acid γ-ester as a chiral source to install
the correct stereochemistry. Both strategies used Dieckmann condensation
to construct a six-membered ring core, after which manipulation of
the functional groups and protecting groups accessed Corey’s
intermediate for the synthesis of oseltamivir phosphate. While the
first synthesis was accomplished via four purification steps in 25.7%
overall yield, albeit with moderate optical purity (76% ee), the second
strategy achieved the synthesis via six purification steps in 19.8%
overall yield with perfect enantiocontrol