2 research outputs found
Aryl–Allene Cyclization via a Hg(OTf)<sub>2</sub>‑Catalytic Pathway
HgÂ(OTf)<sub>2</sub>-catalyzed aryl–allene
cyclization accompanied
by formation of a quaternary carbon center has been realized. Deuterium-labeling
experiments and computational modeling were used to propose a novel
catalytic pathway involving direct H-transfer from the aromatic ring
to the vinyl mercury moiety followed by mercury 1,2-migration
Total Synthesis of (−)-Thallusin: Utilization of Enzymatic Hydrolysis Resolution
(−)-Thallusin, isolated from
a marine bacterium, is the
only known natural product to act as an algal morphogenesis inducer.
Because (−)-thallusin can only be obtained in exceedingly limited
amounts from microbial cultivation, a synthetic supply of this compound
is highly desirable. Here, we describe a novel synthetic pathway to
(±)-thallusin and the first asymmetric synthesis of (−)-thallusin
utilizing the enzymatic hydrolysis resolution with the combination
of lipase PS-30 and lipase M Amamo-10